Spitzbergen 1873 : track of the Diana 1873

Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

De Diana Ephesia

Variantti A.

De Diana Ephesia

Variantti B.

Effectiveness of neutral RAPD markers to detect genetic divergence between the subspecies uncinata and mugo of Pinus mugo Turra

Abstract

Web Software Engineering - value added approach

Taking the maximum advantage of technological innovations and the investment in them is of key importance for businesses. The IT industry offers a wide range of innovative high-technology solutions to manage information processing and distribution. However for end-user businesses to make informed decisions in this area is challenging. The aim of this research is to identify the key differences in principal solutions, and what the selection criteria should be for those involved. Existing methodologies for software development are classified, and some key criteria are described to help IT system developers and users determine what are the most important factors in system selection, development and deployment. Statistical data is researched and analysed, a theoretical basis is developed and reviewed, key issues from case studies are identified and generalized to be presented along with the conclusions in the current study. The results give a good basis for corporate consideration and provide overall support to the key decisions in developing web-based software. The conclusion is that new web developments should be considered the stakeholders as an evolution of existing business systems, but they should then pay particular attention to the new advantages that web-based software offers in terms of standardised interfaces and procedures, universal deployment opportunities, and a range of other benefits the study highlights.

Spectral Color Appearance Modeling

Kuvien laatu on tutkituimpia ja käytetyimpiä aiheita. Tässä työssä tarkastellaan värin laatu ja spektrikuvia. Työssä annetaan yleiskuva olemassa olevista pakattujen ja erillisten kuvien laadunarviointimenetelmistä painottaen näiden menetelmien soveltaminen spektrikuviin. Tässä työssä esitellään spektriväriulkomuotomalli värikuvien laadunarvioinnille. Malli sovelletaan spektrikuvista jäljennettyihin värikuviin. Malli pohjautuu sekä tilastolliseen spektrikuvamalliin, joka muodostaa yhteyden spektrikuvien ja valokuvien parametrien välille, että kuvan yleiseen ulkomuotoon. Värikuvien tilastollisten spektriparametrien ja fyysisten parametrien välinen yhteys on varmennettu tietokone-pohjaisella kuvamallinnuksella. Mallin ominaisuuksien pohjalta on kehitetty koekäyttöön tarkoitettu menetelmä värikuvien laadunarvioinnille. On kehitetty asiantuntija-pohjainen kyselymenetelmä ja sumea päättelyjärjestelmä värikuvien laadunarvioinnille. Tutkimus osoittaa, että spektri-väri –yhteys ja sumea päättelyjärjestelmä soveltuvat tehokkaasti värikuvien laadunarviointiin.

Reactions of Chlorambucil and its main metabolite, Phenylacetic Acid Mustard, with 2’-deoxyribonucleosides and Calf Thymus DNA

Chlorambucil is an anticancer agent used in the treatment of a variety of cancers, especially in chronic lymphocytic leukemia, and autoimmune diseases. Nevertheless, chlorambucil is potentially mutagenic, teratogenic and carcinogenic. The high antitumor activity and high toxicity of chlorambucil and its main metabolite, phenylacetic acid mustard, to normal tissues have been known for a long time. Despite this, no detailed chemical data on their reactions with biomolecules in aqueous media have been available. The aim of the work described in this thesis was to analyze reactions of chlorambucil with 2’-deoxyribonucleosides and calf thymus DNA in aqueous buffered solution, at physiological pH, and to identify and characterize all adducts by using modern analyzing methods. Our research was also focused on the reactions of phenylacetic acid mustard with 2’-deoxynucleosides under similar conditions. A review of the literature consisting of general background of nucleic acids, alkylating agents and ultraviolet spectroscopy used to identify the purine and pyrimidine nucleosides, as well as the results from experimental work are presented and discussed in this doctoral thesis.