Composition and cross-sectional area of muscle fibre types in relation to daily gain and lean and fat content of carcass in Landrace and Yorkshire pigs

Selostus: Lihassolutyypin ja lihassolun poikkipinta-alan yhteys sian kasvuun ja ruhon koostumukseen maatiaisessa ja yorkshiressa

Neck Muscle Function and Adolescent Headache

Muscular function of the neck region may be of importance for the etiology of headache, especially of tension-type headache. However, very few data exist on the association of neck muscle function with different types of headache in adolescents. The main aim of the study was to examine the association of neck muscle function with adolescent headache. The associations between leisure time activities, endurance strength of the upper extremities (UE endurance) and mobility of the neck-shoulder region and adolescent headache were studied. In addition, the associations of force production, EMG/force ratio, co-activation and fatigue characteristics, and cross-sectional area (CSA) of neck muscles with adolescent headache were studied. The study is part of a population-based cohort study of 12-year-old children with and without headache. The study had five phases (years 1998-2003). At the age of 13 years, a sample of 183 adolescents (183/311) participated in endurance strength and mobility measurements of the neck-shoulder region. In addition, the type and level of physical and other leisure activity were elicited with open and structured questions. At the age of 17 years, a random sample of 89 adolescents (89/202) participated in force and EMG measurements of the neck-shoulder muscles. In addition, at the age of 17 years, a sample of 65 adolescents (65/89) participated in CSA measurements of the neck muscles. At the age of 13 years, intensive participation in overall sports activity was associated with migraine. Frequent computer use was associated both with migraine and tension-type headache. The type of sports or other leisure activity classified them on the basis of body loading was not associated with headache type. In girls, low UE endurance of both sides, and low cervical rotation of the dominant side, were associated with tension-type headache, and low UE endurance of non-dominant side with migraine. In boys, no associations occurred between UE endurance and mobility variables and headache types. At the age of 17 years, in girls, high EMG/force ratios between the EMG of the left agonist sternocleidomastoid muscle (SCM) and maximal neck flexion and neck rotation force to the right side as well as high co-activation of right antagonist cervical erector spinae (CES) muscles during maximal neck flexion force were associated with migraine-type headache. In girls, neck force production was not associated with headache types but low left shoulder flexion force was associated with tension-type headache. In boys, no associations were found between EMG and force variables and headache. Increased SCM muscles fatigue of both sides was associated with tension-type headache. In boys, the small CSA of the right SCM muscle and, in girls, of combined right SCM and scalenus muscles was associated with tension-type headache. Similarly, in boys, the large CSA of the right SCM muscle, of the combined right SCM and scalenus muscles, of the left semispinalis capitis muscle, of the combined left semispinalis and splenius muscles was associated with migraine. No other differences in the CSA of neck flexion or extension muscles were found. Differences in the neuromucular function of the neck-shoulder muscles were associated with adolescent headache, especially in girls. Differences in the cross-sectional area of unilateral neck muscles were associated with headache, especially in boys. Differences in the neuromuscular function and in the cross-sectional area of the neck muscles also occurred between different types of headache. It remains to be established whether the findings are primary or secondary to adolescent migraine and tension headache. Keywords: adolescent, cross-sectional area, electromyography, endurance strength, fatigue, force, headache, leisure time activity, migraine, mobility, neck muscles, tension-type headache

The Regulation of Skeletal and Cardiac Muscle Blood Flow in Humans. Studies by positron emission tomography with special reference to exercise, adenosine and nitric oxide

Virtually every cell and organ in the human body is dependent on a proper oxygen supply. This is taken care of by the cardiovascular system that supplies tissues with oxygen precisely according to their metabolic needs. Physical exercise is one of the most demanding challenges the human circulatory system can face. During exercise skeletal muscle blood flow can easily increase some 20-fold and its proper distribution to and within muscles is of importance for optimal oxygen delivery. The local regulation of skeletal muscle blood flow during exercise remains little understood, but adenosine and nitric oxide may take part in this process. In addition to acute exercise, long-term vigorous physical conditioning also induces changes in the cardiovasculature, which leads to improved maximal physical performance. The changes are largely central, such as structural and functional changes in the heart. The function and reserve of the heart’s own vasculature can be studied by adenosine infusion, which according to animal studies evokes vasodilation via it’s a_2A receptors. This has, however, never been addressed in humans in vivo and also studies in endurance athletes have shown inconsistent results regarding the effects of sport training on myocardial blood flow. This study was performed on healthy young adults and endurance athletes and local skeletal and cardiac muscle blod flow was measured by positron emission tomography. In the heart, myocardial blood flow reserve and adenosine A_2A receptor density, and in skeletal muscle, oxygen extraction and consumption was also measured. The role of adenosine in the control of skeletal muscle blood flow during exercise, and its vasodilator effects, were addressed by infusing competitive inhibitors and adenosine into the femoral artery. The formation of skeletal muscle nitric oxide was also inhibited by a drug, with and without prostanoid blockade. As a result and conclusion, it can be said that skeletal muscle blood flow heterogeneity decreases with increasing exercise intensity most likely due to increased vascular unit recruitment, but exercise hyperemia is a very complex phenomenon that cannot be mimicked by pharmacological infusions, and no single regulator factor (e.g. adenosine or nitric oxide) accounts for a significant part of exercise-induced muscle hyperemia. However, in the present study it was observed for the first time in humans that nitric oxide is not only important regulator of the basal level of muscle blood flow, but also oxygen consumption, and together with prostanoids affects muscle blood flow and oxygen consumption during exercise. Finally, even vigorous endurance training does not seem to lead to supranormal myocardial blood flow reserve, and also other receptors than A_2A mediate the vasodilator effects of adenosine. In respect to cardiac work, atheletes heart seems to be luxuriously perfused at rest, which may result from reduced oxygen extraction or impaired efficiency due to pronouncedly enhanced myocardial mass developed to excel in strenuous exercise.

It all comes back to you

Soitinnus: big band.

Recovery of carboxylic acids from aqueous streams by extraction and back extraction

Separation of carboxylic acids from aqueous streams is an important part of their manufacturing process. The aqueous solutions are usually dilute containing less than 10 % acids. Separation by distillation is difficult as the boiling points of acids are only marginally higher than that of water. Because of this distillation is not only difficult but also expensive due to the evaporation of large amounts of water. Carboxylic acids have traditionally been precipitated as calcium salts. The yields of these processes are usually relatively low and the chemical costs high. Especially the decomposition of calcium salts with sulfuric acid produces large amounts of calcium sulfate sludge. Solvent extraction has been studied as an alternative method for recovery of carboxylic acids. Solvent extraction is based on mixing of two immiscible liquids and the transfer of the wanted components form one liquid to another due to equilibrium difference. In the case of carboxylic acids, the acids are transferred from aqueous phase to organic solvent due to physical and chemical interactions. The acids and the extractant form complexes which are soluble in the organic phase. The extraction efficiency is affected by many factors, for instance initial acid concentration, type and concentration of the extractant, pH, temperature and extraction time. In this paper, the effects of initial acid concentration, type of extractant and temperature on extraction efficiency were studied. As carboxylic acids are usually the products of the processes, they are wanted to be recovered. Hence the acids have to be removed from the organic phase after the extraction. The removal of acids from the organic phase also regenerates the extractant which can be then recycled in the process. The regeneration of the extractant was studied by back-extracting i.e. stripping the acids form the organic solution into diluent sodium hydroxide solution. In the solvent regeneration, the regenerability of different extractants and the effect of initial acid concentration and temperature were studied.

Tavanomaisen irtaimen esineen sale and lease back -järjestely. Tarkastelussa erityisesti vuokralleottajan sivullissuoja.

Tutkielman aiheena on tavanomaisen irtaimen esineen sale and lease back -järjestely. Järjestelyyn kuuluu nimensä mukaisesti luovutus ja takaisinvuokraus. Kokonaisjärjestelyn avulla rahoittaja ja luotonsaaja pyrkivät luomaan luotonmaksun vakuudeksi omistusoikeuteen perustuvan esinevakuuden. Järjestelyn tavoitteena on, että luotonsaajan asemassa oleva myyjä pystyisi käyttämään samaa esinettä samanaikaisesti sekä va-kuusobjektina että elinkeinotoimintansa tuotantovälineenä. Juuri siitä syystä, että luo-tonsaaja tarvitsee esinettä koko ajan elinkeinotoiminnassaan, ei panttausta voida käyttää. Tutkielma on oikeusdogmaattinen ja sen pyrkimyksenä on antaa selkeä kokonaiskäsitys irtaimen esineen sale and lease back -järjestelystä ja sen käytettävyydestä vakuusjärjestelynä. Oikeusdogmaattiselle tutkimukselle tyypillisesti tutkielmassa tarkastellaan olemassa olevaa tietomateriaalia. Keskeisimmät tutkielmassa käytetyt kirjallisuuslähteet ovat Jarno Teporan useat sale and lease back -järjestelyyn keskittyvät artikkelit, Jarmo Tuomiston omistusvakuuksia koskeva kirjallisuus sekä Erkki Havansin esineoikeudellinen perusteos Esinevakuudet. Virallislähteistä selvästi merkittävimmät ovat vuonna 1997 voimaantullut maakaari ja sen esityöt. Tutkimuksessa keskitytään erityisesti vuokralleottajan sivullissuojaan. Näin ollen tärkeimmäksi tutkimuskysymykseksi jäsentyy se, voiko sale and lease back -järjestelyssä ostajan roolissa oleva sijoittaja tai rahoittaja saavuttaa järjestelyn avulla kollisiotilanteiden varalta turvaavan vakuusaseman. Tutkimuksen kannalta keskeinen omistusvakuus-järjestely on vakuusluovutus, jollaiseksi vakuustarkoituksessa tehty sale and lease back -järjestely melko vakiintuneesti tulkitaan. Tutkimuksessa tarkastellaan mahdollisuutta hyväksyä sale and lease back -järjestely rahoittajalle dynaamista kollisiosuojaa tarjoavaksi vakuusjärjestelyksi ilman julkivarmistusta. Toisaalta selvitetään julkivarmistuksen toteuttamisen mahdollisuutta ilman hallinnansiirtoa muun muassa maakaaren 14:4.1:n 1 kohdan mukaisen kirjaamisen avulla. Nykylainsäädännön puitteissa järjestelyn hyväksyminen itsenäiseksi omistusvakuudeksi näyttää olevan epätodennäköistä ja ilman julkivarmistusta dynaaminen sivullissuoja jää saavuttamatta, vaikka järjestely on sitova inter partes. Tutkimuksen loppupäätelmissä pohditaan, voisiko sale and lease back -järjestelyyn liittyviä ongelmia ratkaista muuttamalla voimassa olevaa lainsäädäntöä tai antamalla täysin uutta lainsäädäntöä. Asiaa pohditaan myös oikeusvertailun keinoin selvittäen muiden Pohjoismaiden sekä Saksan oikeusjärjestelmien kantaa järjestelyyn.