Sinfonische Metamorphosen über Themen von C. M. von Weber

Soitinnus: orkesteri.

Ein Heldenleben op. 40

Soitinnus: orkesteri.

Michelson interferometer with porch swing bearing for portable FTIR spectrometer

The interferometer for low resolution portable Fourier Transform middle infrared spectrometer was developed and studied experimentally. The final aim was a concept for a commercial prototype. Because of the portability, the interferometer should be compact sized and insensitive to the external temperature variations and mechanical vibrations. To minimise the size and manufacturing costs, Michelson interferometer based on plane mirrors and porch swing bearing was selected and no dynamic alignment system was applied. The driving motor was a linear voice coil actuator to avoid mechanical contact of the moving parts. The driving capability for low mirror driving velocities required by the photoacoustic detectors was studied. In total, four versions of such an interferometer were built and experimentally studied. The thermal stability during the external temperature variations and the alignment stability over the mirror travel were measured using the modulation depth of the wide diameter laser beam. Method for estimating the mirror tilt angle from the modulation depth was developed to take account the effect from the non-uniform intensity distribution of the laser beam. The spectrometer stability was finally studied also using the infrared radiation. The latest interferometer was assembled for the middle infrared spectrometer with spectral range from 750 cm−1 to 4500 cm−1. The interferometer size was (197 × 95 × 79) mm3 with the beam diameter of 25 mm. The alignment stability as the change of the tilt angle over the mirror travel of 3 mm was 5 μrad, which decreases the modulation depth only about 0.7 percent in infrared at 3000 cm−1. During the temperature raise, the modulation depth at 3000 cm−1 changed about 1 . . . 2 percentage units per Celsius over short term and even less than 0.2 percentage units per Celsius over the total temperature raise of 30 °C. The unapodised spectral resolution was 4 cm−1 limited by the aperture size. The best achieved signal to noise ratio was about 38 000:1 with commercially available DLaTGS detector. Although the vibration sensitivity requires still improving, the interferometer performed, as a whole, very well and could be further developed to conform all the requirements of the portable and stable spectrometer.

Aatelisnaisten vaikutusmahdollisuudet 1800-luvulla

Kirjallisuusarvostelu

Metsäperkeleen prinssistä Mäntän kuninkaaksi

Kirjallisuusarvostelu

Sylloge monumentorum, ad illustrandam historiam Fennicam pertinentium 4

Painovuosi nimekkeestä.

The effects of mutated cationic amino acid transporter y+LAT1 at the cellular and systemic level

y+LAT1 is a transmembrane protein that, together with the 4F2hc cell surface antigen, forms a transporter for cationic amino acids in the basolateral plasma membrane of epithelial cells. It is mainly expressed in the kidney and small intestine, and to a lesser extent in other tissues, such as the placenta and immunoactive cells. Mutations in y+LAT1 lead to a defect of the y+LAT1/4F2hc transporter, which impairs intestinal absorbance and renal reabsorbance of lysine, arginine and ornithine, causing lysinuric protein intolerance (LPI), a rare, recessively inherited aminoaciduria with severe multi-organ complications. This thesis examines the consequences of the LPI-causing mutations on two levels, the transporter structure and the Finnish patients’ gene expression profiles. Using fluorescence resonance energy transfer (FRET) confocal microscopy, optimised for this work, the subunit dimerisation was discovered to be a primary phenomenon occurring regardless of mutations in y+LAT1. In flow cytometric and confocal microscopic FRET analyses, the y+LAT1 molecules exhibit a strong tendency for homodimerisation both in the presence and absence of 4F2hc, suggesting a heterotetramer for the transporter’s functional form. Gene expression analysis of the Finnish patients, clinically variable but homogenic for the LPI-causing mutation in SLC7A7, revealed 926 differentially-expressed genes and a disturbance of the amino acid homeostasis affecting several transporters. However, despite the expression changes in individual patients, no overall compensatory effect of y+LAT2, the sister y+L transporter, was detected. The functional annotations of the altered genes included biological processes such as inflammatory response, immune system processes and apoptosis, indicating a strong immunological involvement for LPI.

Yxi vähä suomenkielinen wirsikiria, suomencocouxis Jumalata kijttä suomenkielellä, tehty m. Jacobilda Suomalaiselda, ja muild Suomen papeilda. Cunnjalisten herrain Turun pispan m. Erichin, ja capitularesten tiedhost ja suosjost, H. Hemmingin Maschun kirckoherran vaevall ja culutuxell, ensins präntätty Stocholmisa. Mutta nyt Herman Sulkin käskyst, Staffan Myllärin präntill uudhistettu Rostochis.

Koonnut ja suomentanut Jacobus Finno, täydentänyt Hemminki Henrikinpoika Maskulainen. Useilla lehdillä numerointivirheitä, numerointi: [6], 1-62 93 [po. 63] 64-94 94 [po. 95] 96-161 192 [po. 162] 163-180 161 [po. 181] 182-223, [5]. - Lehtien 197 ja 198 sivut painettu väärään järjestykseen. Viimeisellä sivulla oikolukijan jälkisanat, allekirjoitus S. I. C. S. = Simon Johannis Carelius. Arkit: A-T12 V6. Puuttuu kansalliskokoelmasta.