Albert Lewin. Pandora and the Flying Dutchman: the Semiologic Potential of a Greek Myth

Albert Lewin, a well-known Hollywood cinema director who is significantly influenced by the surrealistic movement, brings together the myth f Pandora and the legend of the flying Dutchman in order to create an exemplary love story, a crazy love story which goes beyond the limits of human reason. Bearing in mind, then, that if one wants to believe in this sort of love story must not be guided by human reason stricto sensu, he builds a world of signs, a semiologic world which this article aims at helping to interpret.

Potential of local bio-geoengineering to mitigate dangerous temperature increases in a global warming scenario

Crops and forests are already responding to rising atmospheric carbon dioxide and air temperatures. Increasing atmospheric CO2 concentrations are expected to enhance plant photosynthesis. Nevertheless, after long-term exposure, plants acclimate and show a reduction in photosynthetic activity (i.e. down-regulation). If in the future the Earth"s temperature is allowed to rise further, plant ecosystems and food security will both face significant threats. The scientific community has recognized that an increase in global temperatures should remain below 2°C in order to combat climate change. All this evidence suggests that, in parallel with reductions in CO2 emissions, a more direct approach to mitigate global warming should be considered. We propose here that global warming could be partially mitigated directly through local bio-geoengineering approaches. For example, this could be done through the management of solar radiation at surface level, i.e. by increasing global albedo. Such an effect has been documented in the south-eastern part of Spain, where a significant surface air temperature trend of -0.3°C per decade has been observed due to a dramatic expansion of greenhouse horticulture.

Potential of antioxidant extracts produced by aqueous processing ofrenewable resources for the formulation of cosmetics

The performance of natural extracts obtained from underutilized and residual vegetal and macroalgal biomass processed with food-grade green solvents was compared with that of commercial antioxidants. Selected extracts were obtained from two terrestrial sources: winery byproducts concentrate (WBC) and chestnut burs hydrothermally fractionated extract (CBAE), and from two underutilized seaweeds: Sargassum muticum extracts, either extracted with ethanol (SmEE) or after alginate extraction and hydrothermal fractionation (SmAE) and from Ulva lactuca processed by mild acid extraction and membrane concentration (UlAE). These extracts showed in vitro antioxidant properties comparable to commercial antioxidants and were safe for topical use based on the absence of skin-irritant effects at 0.1% on reconstructed human tissues. The stability of several cosmetic model emulsions was assessed during accelerated oxidation assays. The incorporation of natural extracts produced from renewable underutilized resources at 0.4-0.5% in an oil-in-water emulsions reduced lipid oxidation during storage.

Potential of local bio-geoengineering to mitigate dangerous temperature increases in a global warming scenario

Crops and forests are already responding to rising atmospheric carbon dioxide and air temperatures. Increasing atmospheric CO2 concentrations are expected to enhance plant photosynthesis. Nevertheless, after long-term exposure, plants acclimate and show a reduction in photosynthetic activity (i.e. down-regulation). If in the future the Earth"s temperature is allowed to rise further, plant ecosystems and food security will both face significant threats. The scientific community has recognized that an increase in global temperatures should remain below 2°C in order to combat climate change. All this evidence suggests that, in parallel with reductions in CO2 emissions, a more direct approach to mitigate global warming should be considered. We propose here that global warming could be partially mitigated directly through local bio-geoengineering approaches. For example, this could be done through the management of solar radiation at surface level, i.e. by increasing global albedo. Such an effect has been documented in the south-eastern part of Spain, where a significant surface air temperature trend of -0.3°C per decade has been observed due to a dramatic expansion of greenhouse horticulture.

Potential of caveolae in the therapy of cardiovascular and neurological diseases.

Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases.

Autosuficiència energètica en nuclis de muntanya: experiència a Araós

A aquest estudi s’ha analitzat si és viable l’autosuficiència energètica en base a un estudi pilot al nucli d’Araós a partir dels recursos renovables locals. S’ha realitzat un anàlisi del consum energètic del nucli d’Araós i s’ha comparat amb el potencial de producció energètica dels recursos renovables locals, incloent energia provinent de la biomassa forestal dels boscos de què disposa el municipi d’Alins i energia solar. Igualment s’han analitzat les emissions de CO2 derivades del consum energètic del poble. S’ha comprovat així que la mitjana de consum per habitant i any d’Araós supera en 1Tep a la mitjana de Catalunya. El 38% del consum d’Araós però, prové de biomassa forestal local, que compta amb unes emissions de CO2 associades pràcticament nul·les. Finalment s’ha detectat que és possible assolir l’autosuficiència energètica d’Araós, mitjançant diferents estratègies d’implantació d’energies renovables. S’han considerat dues estratègies que cobreixen de 3 a 5 vegades el consum energètic: estratègia individual amb instal·lació d’energia solar en teulada i, calefacció i ACS a partir de calderes de biomassa; estratègia col·lectiva mitjançant una central de biomassa forestal. Ambdues representen beneficis energètics, econòmics i fins un 92% de reducció d’emissions de CO2.

Autosuficiència energètica. Estudi pilot a Alinyà (Alt Urgell)

A aquest estudi s'ha analitzat si és viable l'autosuficiència energètica en base a un estudi pilot al nucli rural d'Alinyà aprofitant els recursos naturals de la zona. S'ha realitzat un estudi del consum energètic de la població i s'ha comparat amb el potencial de producció energètica dels recursos renovables locals incloent energia provinent de la biomassa i aprofitada en calderes individuals per a cada habitatge, energia solar en teulades i energia hidroelèctrica a partir de centrals minihidràuliques restaurades ja existents. També s’ha realitzat un anàlisi per detectar possibles factors d’ineficiència energètica i a partir d’aquí, proposar una sèrie de mesures per corregir aquesta. S'han comptabilitzat les emissions de CO2 derivades del consum energètic i les proporcions que representa cada tipus de font energètica sobre el total del nucli. També s'ha establert una comparativa del consum mitjà per habitant i any entre la població i Catalunya; el consum a Alinyà és d'1,46 Tep's, mentre que el de Catalunya és d'1,7 Tep's, el nostre estudi no contempla la mobilitat, si se li resta aquest vector a la mitjana de Catalunya veiem que és de 0,9 Tep's, per tant, hi observem un major consum energètic. El 76% del consum d'Alinyà prové dels combustibles fòssils, concretament del gasoil, el nucli té una forta dependència respecte a aquesta energia, que a més a més representa el 86% (56T CO2 eq.) de les emissions totals de CO2. Per finalitzar, s'ha demostrat que és possible assolir l'autosuficiència energètica mitjançant l'implantació d'una combinació d'estratègies, viables en tots els aspectes; tant tècnics com socioeconòmics. Abastint el poble d'energia a un menor cost econòmic i amb un estil de vida més respectuós amb el medi ambient.

Establishment of an In Vitro Photoallergy Test Using NCTC2544 Cells and IL-18 Production

Differentiation between photoallergenic and phototoxic reactions induced by low molecular weight compounds represents a current problem. The use of eratinocytes as a potential tool for the detection of photoallergens as opposed to photoirritants is considered an interesting strategy for developing in vitro methods. We have previously demonstrated the possibility to use the human keratinocyte cell line NCTC2455 and the production of interleukin-18 (IL-18) to screen low molecular weight sensitizers. The purpose of this work was to explore the possibility to use the NCTC2544 assay to identify photoallergens and discriminate from phototoxic chemicals. First, we identified suitable condition of UV-irradiation (3.5 J/cm2) by investigating the effect of UVAirradiation on intracellular IL-18 on untreated or chloropromazine (a representative phototoxic compound)- treated NCTC2544 cells. Then, the effect of UVA-irradiation over NCTC2544 cells treated with increasing concentrations of 15 compounds including photoallergens (benzophenone, 4-ter-butyl-4-methoxydibenzoylmethane, 2-ethylexyl-p-methoxycinnamate, ketoprofen, 6-methylcumarin); photoirritant and photoallergen (4-aminobenzoic acid, chlorpromazine, promethazine); photoirritants (acridine, ibuprofen, 8-methoxypsoralen, retinoic acid); and negative compounds (lactic acid, SDS and p-phenilendiamine) was investigated. Twenty-four hours after exposure, cytotoxicity was evaluated by the MTT assay or LDH leakage, while ELISA was used to measure the production of IL-18. At the maximal concentration assayed with non-cytotoxic effects (CV80 under irradiated condition), all tested photoallergens induced a significant and a dose-dependent increase of intracellular IL-18 following UVA irratiation, whereas photoirritants failed. We suggest that this system may be useful for the in vitro evaluation of the photoallergic potential of chemicals.