Potential of caveolae in the therapy of cardiovascular and neurological diseases.
| Contribuinte(s) |
Universitat de Barcelona |
|---|---|
| Resumo |
Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases. |
| Identificador | |
| Idioma(s) |
eng |
| Publicador |
Frontiers Media |
| Direitos |
cc-by (c) Navarro, Gemma et al., 2014 info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by/3.0/es">http://creativecommons.org/licenses/by/3.0/es</a> |
| Palavras-Chave | #Malalties del sistema nerviós #Membranes cel·lulars #Malalties cardiovasculars #Proteïnes de membrana #Nervous System Diseases #Cell membranes #Cardiovascular diseases #Membrane proteins |
| Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
