Inhibition of nociceptive responses after systemic administration of amidated kyotorphin

BACKGROUND AND PURPOSE Kyotorphin (KTP; L-Tyr-L-Arg), an endogenous neuropeptide, is potently analgesic when delivered directly to the central nervous system. Its weak analgesic effects after systemic administration have been explained by inability to cross the blood-brain barrier (BBB) and detract from the possible clinical use of KTP as an analgesic. In this study, we aimed to increase the lipophilicity of KTP by amidation and to evaluate the analgesic efficacy of a new KTP derivative (KTP-amide - KTP-NH 2). EXPERIMENTAL APPROACH We synthesized KTP-NH 2. This peptide was given systemically to assess its ability to cross the BBB. A wide range of pain models, including acute, sustained and chronic inflammatory and neuropathic pain, were used to characterize analgesic efficacies of KTP-NH 2. Binding to opioid receptors and toxicity were also measured. KEY RESULTS KTP-NH 2, unlike its precursor KTP, was lipophilic and highly analgesic following systemic administration in several acute and chronic pain models, without inducing toxic effects or affecting motor responses and blood pressure. Binding to opioid receptors was minimal. KTP-NH 2 inhibited nociceptive responses of spinal neurons. Its analgesic effects were prevented by intrathecal or i.p. administration of naloxone. CONCLUSIONS AND IMPLICATIONS Amidation allowed KTP to show good analgesic ability after systemic delivery in acute and chronic pain models. The indirect opioid-mediated actions of KTP-NH 2 may explain why this compound retained its analgesic effects although the usual side effects of opioids were absent, which is a desired feature in next-generation pain medications

Personal constructs in systemic practice

This paper intends to elaborate the relationship between Kelly's Personal Construct Theory (PCT) and the systemic therapies beyond their notable similarities. Kelly's constructive alternativism is situated in the context of the current constructivist orientation that the family therapy movement seems to be adopting. A model of change is presented based on PCT's experience cycle. From this cycle, the relationship between behaviors and constructions is elaborated incorporating Procter's (52, 53) notions of the Family Construct System (FCS) andposition. This model allows for interventions both at behavioral and construction levels, as well as allowing for a certain technical eclecticism while, at the same time, retaining a strong theoretical coherence. This approach is discussed in the context of the debate about strategizing, power, and control held by authors such as Golann, Hoffman, and Tomm. Finally, some implications for research are outlined.

La crisis o nuevos mecanismos de acumulación por desposesión de la reproducción

Desde que empezó la crisis hemos presenciado un doble proceso político que amenaza con socavar algunos de los avances más importantes en materia de igualdad de género realizados en época reciente. Por un lado, hemos asistido a un inmenso recorte del gasto público social y, por el otro, al ascenso por doquier de la derecha, la cual desempolva obcecada sus recetas de auxilio a la familia tradicional para salvarla de los supuestamente crecientes y virulentos ataques perpetrados sobre esta durante los últimos años. Estos dos procesos se encuentran profundamente relacionados y contribuyen a provocar nuevos y actualizados mecanismos de acumulación por desposesión del trabajo reproductivo no remunerado de las mujeres.

Factores Psicosociales y Organizaciones Saludables en tiempos de crisis

Presentación del Modelo de empresa saludable y sostenible y del Modelo para la intervención psicosocial laboral.

Organizaciones saludables en tiempo de crisis

Peer-reviewed

Juventud, trabajo y desempleo en los prolegómenos de la crisis económica en España. Reflexiones críticas

La elevada y preocupante cifra de desempleo juvenil hoy día en España invita a reflexionar sobre cómo era esta situación en los prolegómenos de la actual crisis económica y social. En el presente artículo se analiza y reflexiona si tras la explicación predominante, basada en la responsabilización del joven, se eludían otros aspectos interesantes a tener en cuenta. Para ello se aplica una metodología variada, basada en la revisión estadística y documental, complementada con observación participante y entrevistas (semiestructuradas y estructuradas) a jóvenes (16-19 años), a profesionales del ámbito educativo-ocupacional y a responsables de la administración local. La principal aportación realizada es, por un lado, la identificación, a partir del análisis empírico, de algunas reflexiones en torno a elementos que cuestionan el discurso culpabilizador hacia el joven, y por otro lado, la presentación de elementos exógenos a la figura del joven interesantes de incorporar en el análisis sobre jóvenes e inserción laboral.

Dinamitzar sectors d'alt valor afegit evitarà crisis

Segons dades de Biocat, Catalunya té el 21% de les empreses del sector biotecnològic espanyol que mouen més de 15.000 milions d'euros i ocupen més de 22.000 persones. A final del 2011, en el sector hi constaven 1.156 empreses i entitats, incloent-hi centres de recerca. De les 481 empreses, un 84% són d'origen català. Una part important són d'R+D+I i d'àmbit en què les universitats i centres de recerca catalans estan més ben situats en els rànquings internacionals

La repercusión de la crisis en las entidades financieras: el caso de Lleida

Tras dos décadas con todo a favor para las entidades bancarias españolas, sobre todo para las cajas de ahorros, en cuento a su crecimiento y su expansión, la llegada de la crisis actual ha cambiado toda esta tendencia. El proceso de reestructuración del sistema bancario español a partir de 2009 provoca grandes transformaciones dentro del sector financiero, que afectan especialmente a las mismas cajas. Estos cambios son visibles a diferentes escalas del territorio. Por ello en este trabajo descubriremos el comportamiento de las oficinas bancarias en la ciudad de Lleida, especialmente durante el reciente período para averiguar las repercusiones que pueden tener estas medidas en una ciudad de tamaño medio, pero para ello encuadraremos nuestro trabajo en otras escalas territoriales.

La importancia de una buena gestión de comunicación en situaciones de crisis. El caso de ébola en España

Aquest Treball Final de Grau se centra en la gestió de comunicació en les situacions de crisis institucionals, donat que aquestes han demostrat que la imatge és un dels actius més rellevants en les organitzacions. Per atenuar totes les conseqüències negatives de les crisis, s’ha de comprometre’s a la preparació i a la prevenció dels riscos des de tots els punts de vista. Les crisis ben gestionades poden ser oportunitats per reposicionar una marca i, a la vegada, enfortir-la. Per aquest motiu, una bona gestió de crisis és la base per intentar evitar una crisis o, en el cas que succeeixi, sortir il·lès de les conseqüències i millorar la imatge de l’entitat. A més a més, per recalcar la importància d’una bona preparació abans que esdevingui la crisis, s’analitza un cas - la crisis sanitària de l’ebola a España - on es reflexa clarament la necessitat d’estar previngut.

Los efectos de la sociedad en los museos: del boom a la crisis de ideas = The effects of the society in museums: from boom to the ideas crisis

This paper compares different times of museums considering the situation of the past two decades. It reflects on the upswing and down, knowing that partake of the latter and we are in a deep crisis and unsustainable policies dictating contradictory. This situation raises the museums with their own project and creative professionals can better overcome difficulties because they do not suffer crisis of ideas. Some paradoxes are evident as the case of Greece, the place where the museums are repositories of highly relevant cultural values and the same institutions that have enhanced their improvement in the years of the upswing, they currently require, cuts that put them in a position risk. Similarly we can see that policies are applied to thin the identity of museums since they rely on adjustments that do not study each particular case. Alternatively there is the creativity and efforts of managers and professionals in general and cooperative work. It gives details of some of our participatory projects that go in this direction and to be successfully applied

¿Crisis de la cultura? = Crisis of the culture?

Culture has several meanings: civilization, creation, knowledge, life… We analyze how each one suffers the so-called crisis of culture. Civilization lives the crisis as «liquidity», according to Bauman’s diagnosis, with significant negative impact on education. The creation and enjoyment of cultural products, such as museums, suffer its crisis as fragility resulting from the civilization crisis, notably in the form of consumerist banality or pure entertainment. Culture as knowledge and as life is analyzed under the joint notion «humanistic culture». This, which in turn is creation, knowledge and life has its specific corruption in the elitist knowledge, merely theoretical. The hallmark of genuine humanism contains an essential component, the dimension of ethical and political commitment. The crisis in the humanistic studies, noted by Nussbaum, threats the values of humanistic culture; in particular is a political risk, because democracy is a system that needs to sustain and improve the values of humanistic culture. In the background, and beyond the differences between the cultural meanings, there is a unique cultural crisis, a crisis of ethics and politics at a time

Systemic lupus erythematosus in the elderly: Clinical and immunological characteristics.

Systemic lupus erythematosus (SLE) predominantly affects young women in their 20s. In 40 out of 250 (16%) patients with SLE seen in our hospital disease onset occurred after the age of 50. The interval between the time of onset and diagnosis was five years in this older group compared with three years in the younger group. Arthritis, as a first symptom, was less common in the older onset group. During the follow up a lower incidence of arthritis, malar rash, photosensitivity, and nephropathy was found in the older onset group. In contrast, this group showed an increased incidence of myositis. High titres of anti-dsDNA tended to occur less often and the incidence of anti-Ro antibodies was lower in the older onset group. These features seem to distinguish patients with older onset SLE as a particular subset.

Isotype distribution of anticardiolipin antibodies in systemic lupus erythematosus prospective analysis of a series of 100 patients

A prospective study of IgG and IgM isotypes of anticardiolipin antibodies (aCL) in a series of 100 patients with systemic lupus erythematosus was carried out. To determine the normal range of both isotype titres a group of 100 normal control serum samples was studied and a log-normal distribution of IgG and IgM isotypes was found. The IgG anticardiolipin antibody serum was regarded as positive if a binding index greater than 2.85 (SD 3.77) was detected and a binding index greater than 4.07 (3.90) was defined as positive for IgM anticardiolipin antibody. Twenty four patients were positive for IgG aCL, 20 for IgM aCL, and 36 for IgG or IgM aCL, or both. IgG aCL were found to have a significant association with thrombosis and thrombocytopenia, and IgM aCL with haemolytic anaemia and neutropenia. Specificity and predictive value for these clinical manifestations increased at moderate and high anticardiolipin antibody titres. In addition, a significant association was found between aCL and the presence of lupus anticoagulant. Identification of these differences in the anticardiolipin antibody isotype associations may improve the clinical usefulness of these tests, and this study confirms the good specificity and predictive value of the anticardiolipin antibody titre for these clinical manifestations.

Cardiac disease in systemic lupus erythematosus: prospective study of 70 patients.

A prospective two dimensional and Doppler echocardiographic study of 70 consecutive patients with systemic lupus erythematosus (SLE) and 40 controls was carried out. Forty patients (57%) were found to have echocardiographic disturbance. Valvular abnormalities were detected in 31 patients (44%) and in only two controls (5%). Mitral valve abnormalities were the most common findings (23/70 (33%)) with mild or moderate regurgitation the most frequent lesion (16% and 9% respectively). Three patients (4%) had a morphological echocardiographic pattern suggestive of non-infective verrucous vegetations affecting the mitral valve. No patient had haemodynamically significant clinical valve disease. Pericardial effusion was identified in 19 patients (27%), of whom 14 had mild and clinically silent disease. Myocardial abnormalities were found in 14 patients (20%), but clinical features of myocardial dysfunction were present in only one. Patients with antiphospholipid antibodies were found to have an increased prevalence of endocardial lesions, mainly valvular regurgitation. It is concluded that the inclusion of echocardiography in a study protocol of patients with SLE can identify an important subset of patients with cardiac abnormalities, many of which are clinically silent. In addition, the association of antiphospholipid antibodies with endocardial lesions suggests that these antibodies may have a prominent role in the pathogenetic mechanisms of heart valve disease in SLE.

Systemic lupus erythematosus in men: clinical and immunological characteristics.

Although systemic lupus erythematosus (SLE) has traditionally been considered a disease of women, men may also be affected. Thirty of 261 patients (12%) with SLE seen in this hospital were men. Arthritis was less common as a first symptom in the men, although this group of patients had discoid lesions and serositis more often than the women. During the follow up a lower incidence of arthritis and malar rash and a higher incidence of other skin complications including discoid lesions and subcutaneous lupus erythematosus was found in the men. The incidence of nephropathy, neurological disease, thrombocytopenia, vasculitis, and serositis, was similar in the two groups. No significant immunological differences were found between men and women. These features indicate that several gender associated clinical differences may be present in patients with SLE.