Antipsychotic polypharmacy in a regional health service: a population-based study

Background To analyse the extent and profile of outpatient regular dispensation of antipsychotics, both in combination and monotherapy, in the Barcelona Health Region (Spain), focusing on the use of clozapine and long-acting injections (LAI). Methods Antipsychotic drugs dispensed for people older than 18 and processed by the Catalan Health Service during 2007 were retrospectively reviewed. First and second generation antipsychotic drugs (FGA and SGA) from the Anatomical Therapeutic Chemical classification (ATC) code N05A (except lithium) were included. A patient selection algorithm was designed to identify prescriptions regularly dispensed. Variables included were age, gender, antipsychotic type, route of administration and number of packages dispensed. Results A total of 117,811 patients were given any antipsychotic, of whom 71,004 regularly received such drugs. Among the latter, 9,855 (13.9%) corresponded to an antipsychotic combination, 47,386 (66.7%) to monotherapy and 13,763 (19.4%) to unspecified combinations. Of the patients given antipsychotics in association, 58% were men. Olanzapine (37.1%) and oral risperidone (36.4%) were the most common dispensations. Analysis of the patients dispensed two antipsychotics (57.8%) revealed 198 different combinations, the most frequent being the association of FGA and SGA (62.0%). Clozapine was dispensed to 2.3% of patients. Of those who were receiving antipsychotics in combination, 6.6% were given clozapine, being clozapine plus amisulpride the most frequent association (22.8%). A total of 3.800 patients (5.4%) were given LAI antipsychotics, and 2.662 of these (70.1%) were in combination. Risperidone was the most widely used LAI. Conclusions The scant evidence available regarding the efficacy of combining different antipsychotics contrasts with the high number and variety of combinations prescribed to outpatients, as well as with the limited use of clozapine. Background To analyse the extent and profile of outpatient regular dispensation of antipsychotics, both in combination and monotherapy, in the Barcelona Health Region (Spain), focusing on the use of clozapine and long-acting injections (LAI). Methods Antipsychotic drugs dispensed for people older than 18 and processed by the Catalan Health Service during 2007 were retrospectively reviewed. First and second generation antipsychotic drugs (FGA and SGA) from the Anatomical Therapeutic Chemical classification (ATC) code N05A (except lithium) were included. A patient selection algorithm was designed to identify prescriptions regularly dispensed. Variables included were age, gender, antipsychotic type, route of administration and number of packages dispensed. Results A total of 117,811 patients were given any antipsychotic, of whom 71,004 regularly received such drugs. Among the latter, 9,855 (13.9%) corresponded to an antipsychotic combination, 47,386 (66.7%) to monotherapy and 13,763 (19.4%) to unspecified combinations. Of the patients given antipsychotics in association, 58% were men. Olanzapine (37.1%) and oral risperidone (36.4%) were the most common dispensations. Analysis of the patients dispensed two antipsychotics (57.8%) revealed 198 different combinations, the most frequent being the association of FGA and SGA (62.0%). Clozapine was dispensed to 2.3% of patients. Of those who were receiving antipsychotics in combination, 6.6% were given clozapine, being clozapine plus amisulpride the most frequent association (22.8%). A total of 3.800 patients (5.4%) were given LAI antipsychotics, and 2.662 of these (70.1%) were in combination. Risperidone was the most widely used LAI. Conclusions The scant evidence available regarding the efficacy of combining different antipsychotics contrasts with the high number and variety of combinations prescribed to outpatients, as well as with the limited use of clozapine.

Implementación de una plataforma de servidores de aplicaciones

El proyecto consiste en el análisis, instalación y configuración de una plataforma de servidores de aplicaciones para el Ayuntamiento de Terrassa. Este tipo de plataformas permiten ejecutar aplicaciones en un entorno aislado y ofrecerlas como un servicio bajo demanda. La aplicaciones se instalan, mantienen y actualizan en el centro de datos simplificando de esta forma su gestión. Por otro lado, tenemos que integrar esta nueva plataforma con otra ya existente. Esta integración tiene que ser lo más transparente posible para los usuarios.

WiBed, A Platform for Commodity Wireless Testbeds

Testbeds are a stage between the simulation and the production stages. To this end they must be as close as possible to production environments (i.e. real hardware, on the field deployments) while also keeping the traits of experimentation facilities (i.e. fault tolerance, ease of deployment, testing and data collection). This paper presents WiBed, a FOSS platform for WiFi testbeds based on OpenWRT Linux made to run oncommodity IEEE802.11 WiFi routers part of the Community-lab.net project, a global testbed for Community networks. WiBedhas been designed to support realistic low layer network exper-iments (according to the OSI model). This work recolects thedetails of the architecture, design and implementation of WiBed consolidated during its operation as a testbed. In addition to a set of routing experimentation results obtained during the Wireless Battlemesh v7 where WiBed was used as testbed platform.

Measuring service quality in sport management: an application of the SERVQUAL scale

The aim of this study is to provide an instrument for measuring service quality in sports enterprises from the point of view of the customers. For this purpose we intend to elaborate an enquiry starting out from a more general scale called SERVIQUAL. We have limited our research project to sports enterprises where the customer participates actively, i.e., we have excluded sports clubs and other organizations which offer sport as entertainment. Our choice is mainly due to the fact that few studies have been carried out in this area and that sports has been earning an increasing amount of adepts during the last decades in Spain. The DELPHI method has been applied with the collaboration of a panel of experts in order to evaluate the viability and adequacy of the modified SERVQUAL scale.

Building a usable and accessible semantic web interaction platform

Semantic Web applications take off is being slower than expected, at least with respect to “real-world” applications and users. One of the main reasons for this lack of adoption is that most Semantic Web user interfaces are still immature from the usability and accessibility points of view. This is due to the novelty of these technologies, but this also motivates the exploration of alternative interaction paradigms, different from the “traditional” Web or Desktop applications ones. Our proposal is realized in the Rhizomer platform, which explores the possibilities of the object–action interaction paradigm at the Web scale. This paradigm is well suited for heterogeneous resource spaces such as those common in the Semantic Web. Resources, described by metadata, correspond to the objects in the paradigm. Semantic web services, which are dynamically associated to these objects, correspond to the actions. The platform is being put into practice in the context of a research project in order to build an open application for media distribution based on Semantic Web technologies. Moreover, its usability and accessibility have been evaluated in this real setting and compared to similar systems.

Consideraciones acerca de los límites de aplicación del método del número de Curva del Soil Conservation Service

En el presente artículo se revisan las limitaciones de aplicación del método del Número de Curva del Soil Conservation Service, modelo conceptual ampliamente difundido para el cálculo de la escorrentía originada por una tormenta. Si bien es cierto que el método posee una serie de capacidades y ventajas que han motivado su éxito en la modelación hidrológica, en particular su simplicidad de uso y la economía en la obtención de los datos físicos necesarios, no es menos cierto que deben contemplarse una serie de restricciones de aplicación. La amplia difusión de la que ha sido objeto ha propiciado la discusión y revisión crítica del modelo, acotando paulatinamente sus límites. Entre los más significativos de éstos, destacan la necesidad de regionalizar, a partir de campañas de aforos, ciertas hipótesis y parámetros del método, así como las precauciones que deben adoptarse si se aplica a cuencas forestales densas con suelos muy permeables.

WiBed, a platform for commodity wireless testbeds

This paper presents WiBed, a FOSS platform for WiFi testbeds based on OpenWRT Linux made to run on commodity IEEE802.11 WiFi routers part of the Community-lab.net project, a global testbed for Community networks. WiBed has been designed to support realistic low layer network experiments (according to the OSI model). This work recolects the details of the architecture, design and implementation of WiBed consolidated during its operation as a testbed.