Patología Dual y rasgos de personalidad:situación actual y líneas futuras de trabajo

Dual diagnosis (DD) is the co-occurrence, in the same person, of a mental disorder (MD) and a substance use disorder (SUD). Nowadays, the study of the personality with DD is realized mainly from a categorical view, focusing on the detection of personality disorders and not on the traits associated to DD and the possible differential profile compared to those patients with only MD or SUD. Studies analyzing personality traits of patients with DD and their possible differential profile are very limited. However, existing data indicates that DD patients show higher levels of Sensation Seeking, Impulsivity, Harm Avoidance and Neuroticism; and lower levels of Persistence, Self-Direction, Self-Transcendence and Cooperation. Therefore, DD is associated to personality characteristics that suggest more disruptive behaviors, fewer resources for recovering and keeping abstinent and worse prognosis compared to those with only one disorder. Progress in the characterization of personality traits in DD, taking into consideration the methodological aspects to be improved could allow better adaptation of the integrated treatment of these patients in the future.

A common cognitive, psychiatric, and dysmorphic phenotype in carriers of NRXN1 deletion

Deletions in the 2p16.3 region that includes the neurexin (NRXN1) gene are associated with intellectual disability and various psychiatric disorders, in particular, autism and schizophrenia. We present three unrelated patients, two adults and one child, in whom we identified an intragenic 2p16.3 deletion within the NRXN1 gene using an oligonucleotide comparative genomic hybridization array. The three patients presented dual diagnosis that consisted of mild intellectual disability and autism and bipolar disorder. Also, they all shared a dysmorphic phenotype characterized by a long face, deep set eyes, and prominent premaxilla. Genetic analysis of family members showed two inherited deletions. A comprehensive neuropsychological examination of the 2p16.3 deletion carriers revealed the same phenotype, characterized by anxiety disorder, borderline intelligence, and dysexecutive syndrome. The cognitive pattern of dysexecutive syndrome with poor working memory and reduced attention switching, mental flexibility, and verbal fluency was the same than those of the adult probands. We suggest that in addition to intellectual disability and psychiatric disease, NRXN1 deletion is a risk factor for a characteristic cognitive and dysmorphic profile. The new cognitive phenotype found in the 2p16.3 deletion carriers suggests that 2p16.3 deletions might have a wide variable expressivity instead of incomplete penetrance

Programas, intervenciones y redes de apoyo a los cuidadores informales en salud. Necesidad de convergencia entre los programas formales y el apoyo informal

Hacerse cargo del cuidado de un familiar dependiente puede afectar negativamente a la salud del cuidador/a en su vida afectiva y laboral. Las repercusiones del cuidado informal preocupan a las diferentes administraciones y también a los profesionales sanitarios, quienes se proponen ofrecer el soporte más adecuado a los cuidadores familiares, para que puedan seguir desempeñando las actividades derivadas del cuidado y a su vez minimicen el cansancio y la carga que supone cuidar. Desde hace una década se ha venido acrecentando el interés por planificar y desarrollar programas de soporte, desde la iniciativa pública y privada, dirigidos a cuidadores familiares. Los contenidos de estos programas son de diversa índole, y ofrecen asesoramiento e información, apoyo emocional, ayuda económica o descargas temporales del cuidado de las personas dependientes. La literatura científica revisada coincide en la importancia y la necesidad de coordinación y complementariedad que debe darse entre las redes informales y formales en el soporte a los cuidadores de las personas dependientes.

Cognició i emoció: Sobre les relacions entre memòria i emoció i la congruència del record amb l'estat afectiu

El següent treball tracta sobre les principals relacions existents entre la memòria i les emocions. Una vegada revisats els dos conceptes de manera separada, el nostre objectiu serà vincular els dos conceptes, per tal de saber com influeixen les emocions en el processos mnèmics com són la codificació, la consolidació i el record. Per assolir aquest objectiu, també realitzarem una part empírica en la qual prendrem com a referent la teoria de la Memòria Dependent de l'Estat d'Ànim proposada per Bower (1981). En la línia d'aquesta teoria, la hipòtesi general que ens plantegem a la part empírica és que si induïm a un subjecte a un estat d'ànim determinat i li fem aprendre un llistat de paraules amb diferent valència emocional, recordarà millor les paraules que coincideixin amb l'estat afectiu del subjecte en el moment de l'aprenentatge. Per a resoldre aquesta hipòtesi prendrem com a referent el disseny experimental de Meilan, Carro, Guerrero, Carpi, Gómez & Palmero (2012). Els nostres resultats recolzen les hipòtesis basades en la teoria de congruència afectiva de Bower (1981) i, parcialment el disseny d'investigació de Meilan et. al (2012).

Massive protostars as gamma-ray sources.

Massive protostars have associated bipolar outflows with velocities of hundreds of km s-1. Such outflows can produce strong shocks when they interact with the ambient medium leading to regions of nonthermal radio emission. Aims. We aim at exploring under which conditions relativistic particles are accelerated at the terminal shocks of the protostellar jets and whether they can produce significant gamma-ray emission. Methods. We estimate the conditions necessary for particle acceleration up to very high energies and gamma-ray production in the nonthermal hot spots of jets associated with massive protostars embedded in dense molecular clouds. Results. We show that relativistic bremsstrahlung and proton-proton collisions can make molecular clouds with massive young stellar objects detectable by the Fermi satellite at MeV-GeV energies and by Cherenkov telescope arrays in the GeV-TeV range. Conclusions. Gamma-ray astronomy can be used to probe the physical conditions in star-forming regions and particle acceleration processes in the complex environment of massive molecular clouds.