DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests

The identification of biomarkers of vascular cognitive impairment is urgent for its early diagnosis. The aim of this study was to detect and monitor changes in brain structure and connectivity, and to correlate them with the decline in executive function. We examined the feasibility of early diagnostic magnetic resonance imaging (MRI) to predict cognitive impairment before onset in an animal model of chronic hypertension: Spontaneously Hypertensive Rats. Cognitive performance was tested in an operant conditioning paradigm that evaluated learning, memory, and behavioral flexibility skills. Behavioral tests were coupled with longitudinal diffusion weighted imaging acquired with 126 diffusion gradient directions and 0.3 mm(3) isometric resolution at 10, 14, 18, 22, 26, and 40 weeks after birth. Diffusion weighted imaging was analyzed in two different ways, by regional characterization of diffusion tensor imaging (DTI) indices, and by assessing changes in structural brain network organization based on Q-Ball tractography. Already at the first evaluated times, DTI scalar maps revealed significant differences in many regions, suggesting loss of integrity in white and gray matter of spontaneously hypertensive rats when compared to normotensive control rats. In addition, graph theory analysis of the structural brain network demonstrated a significant decrease of hierarchical modularity, global and local efficacy, with predictive value as shown by regional three-fold cross validation study. Moreover, these decreases were significantly correlated with the behavioral performance deficits observed at subsequent time points, suggesting that the diffusion weighted imaging and connectivity studies can unravel neuroimaging alterations even overt signs of cognitive impairment become apparent.

Noradrenergic stimulation enhances human action monitoring

Noradrenergic neurotransmission has been associated with the modulation of higher cognitive functions mediated by the prefrontal cortex. In the present study, the impact of noradrenergic stimulation on the human action-monitoring system, as indexed by eventrelated brain potentials, was examined. After the administration of a placebo or the selective 2 -adrenoceptor antagonist yohimbine, which stimulates firing in the locus ceruleus and noradrenaline release, electroencephalograpic recordings were obtained from healthy volunteers performing a letter flanker task. Yohimbine led to an increase in the amplitude of the error-related negativity in conjunction with a significant reduction of action errors. Reaction times were unchanged, and the drug did not modify the N2 in congruent versus incongruent trials, a measure of preresponse conflict, or posterror adjustments as measured by posterror slowing of reaction time. The present findings suggest that the locus ceruleusnoradrenaline system exerts a rather specific effect on human action monitoring.

Nucleus accumbens is involved in human action monitoring: evidence from invasive electrophysiological recordings

The Nucleus accumbens (Nacc) has been proposed to act as a limbic-motor interface. Here, using invasive intraoperative recordings in an awake patient suffering from obsessive-compulsive disease (OCD), we demonstrate that its activity is modulated by the quality of performance of the subject in a choice reaction time task designed to tap action monitoring processes. Action monitoring, that is, error detection and correction, is thought to be supported by a system involving the dopaminergic midbrain, the basal ganglia, and the medial prefrontal cortex. In surface electrophysiological recordings, action monitoring is indexed by an error-related negativity (ERN) appearing time-locked to the erroneous responses and emanating from the medial frontal cortex. In preoperative scalp recordings the patient's ERN was found to be signifi cantly increased compared to a large (n = 83) normal sample, suggesting enhanced action monitoring processes. Intraoperatively, error-related modulations were obtained from the Nacc but not from a site 5 mm above. Importantly, crosscorrelation analysis showed that error-related activity in the Nacc preceded surface activity by 40 ms. We propose that the Nacc is involved in action monitoring, possibly by using error signals from the dopaminergic midbrain to adjust the relative impact of limbic and prefrontal inputs on frontal control systems in order to optimize goal-directed behavior.

Data mining and mall users profile

Marketing scholars have suggested a need for more empirical research on consumer response to malls, in order to have a better understanding of the variables that explain the behavior of the consumers. The segmentation methodology CHAID (Chi-square automatic interaction detection) was used in order to identify the profiles of consumers with regard to their activities at malls, on the basis of socio-demographic variables and behavioral variables (how and with whom they go to the malls). A sample of 790 subjects answered an online questionnaire. The CHAID analysis of the results was used to identify the profiles of consumers with regard to their activities at malls. In the set of variables analyzed the transport used in order to go shopping and the frequency of visits to centers are the main predictors of behavior in malls. The results provide guidelines for the development of effective strategies to attract consumers to malls and retain them there.

Reward networks in the brain as captured by connectivity measures

An assortment of human behaviors is thought to be driven by rewards including reinforcement learning, novelty processing, learning, decision making, economic choice, incentive motivation, and addiction. In each case the ventral tegmental area/ventral striatum (nucleus accumbens) (VTAVS) system has been implicated as a key structure by functional imaging studies, mostly on the basis of standard, univariate analyses. Here we propose that standard functional magnetic resonance imaging analysis needs to be complemented by methods that take into account the differential connectivity of the VTAVS system in the different behavioral contexts in order to describe reward based processes more appropriately. We fi rst consider the wider network for reward processing as it emerged from animal experimentation. Subsequently, an example for a method to assess functional connectivity is given. Finally, we illustrate the usefulness of such analyses by examples regarding reward valuation, reward expectation and the role of reward in addiction.

Epigenètica i futur dels infants

Una de les característiques que defineixen els éssers vius és la seva capacitat per adaptar-se a l'entorn. Evolutivament parlant, les espècies es van adaptant per l'acumulació de mutacions atzaroses que alteren el missatge genètic i per l'acció de la selecció natural. Tanmateix, a curt termini, en el decurs de la vida d'un organisme, aquest també s'ha d'adaptar al seu entorn particular. En el cas dels vertebrats superiors, com les persones, bona part d'aquesta adaptació individual s'aconsegueix amb el comportament, que s'origina al cervell [...].

Aproximación a los factores explicativos del desistimiento en jóvenes infractores

L'article té per objectiu explorar quins factors esdevenen rellevants per al cessament de la conducta delictiva en menors i joves infractors,relacionant dos conceptes que malgrat que provenen d'àmbits disciplinaris diferents, el desistiment i la resiliència, tenen força elements en comú. En l'estudi participen un total de 110 joves de la província de Barcelona entre 14 i 17 anys que es troben pendent d'inici, en execució o han finalitzat un programa socioeducatiu (mediació, medi obert o internament) en l'àmbit de la justícia juvenil. S'utilitza un qüestionari i una fitxa per recollir informació de les bases de dades del Departament de Justícia de la Generalitat de Catalunya. Els principals resultats indiquen que un passat advers no dificulta el desistiment, i que l'acció de factors de protecció contextuals i individuals fa minvar el risc de reincidència.

Degradación de T-patterns en estudios observacionales: Un estudio sobre la eficacia en el ataque de fútbol sala

Una de las técnicas analíticas más novedosas en el ámbito de la metodología observacional es la que permite la detección de T-patterns (estructuras regulares de conducta) mediante el software THEME, que analiza datos observacionales en búsqueda de relaciones de intervalo crítico en sentido ascendente (desde T-pattern simples, dos eventos que se relacionan en un primer nivel, a T-patterns complejos constituidos por diferentes eventos relacionados en distintos niveles). En el presente artículo se analiza esta cuestión, la degradación de los T-patterns, que hasta el momento ha sido puntualmente estudiada. Para ello, se utiliza el muestreo observacional constituido por el conjunto de las secuencias que acaban en gol (n= 23) protagonizadas por el F.C. Barcelona durante el Play Off Final de la liga española 2012-13 de fútbol sala. De esta forma este trabajo satisface un segundo objetivo, en este caso disciplinar, de analizar la e'cacia en la construcción de la fase ofensiva en el fútbol sala; habiéndose tipi'cado que las secuencias que 'nalizan en gol se caracterizan por conseguir, mediante juego combinativo, un lanzamiento desde sector de'nición-corredor central.

Predictors and consequences of adherence to the treatment of pediatric patients with attention-deficit/hyperactivity disorder in Central Europe and East Asia.

PURPOSE: To assess baseline predictors and consequences of medication non-adherence in the treatment of pediatric patients with attention-deficit/hyperactivity disorder (ADHD) from Central Europe and East Asia. PATIENTS AND METHODS: Data for this post-hoc analysis were taken from a 1-year prospective, observational study that included a total of 1,068 newly-diagnosed pediatric patients with ADHD symptoms from Central Europe and East Asia. Medication adherence during the week prior to each visit was assessed by treating physicians using a 5-point Likert scale, and then dichotomized into either adherent or non-adherent. Clinical severity was measured by the Clinical Global Impressions-ADHD-Severity (CGI-ADHD) scale and the Child Symptom Inventory-4 (CSI-4) Checklist. Health-Related Quality of Life (HRQoL) was measured using the Child Health and Illness Profile-Child Edition (CHIP-CE). Regression analyses were used to assess baseline predictors of overall adherence during follow-up, and the impact of time-varying adherence on subsequent outcomes: response (defined as a decrease of at least 1 point in CGI), changes in CGI-ADHD, CSI-4, and the five dimensions of CHIP-CE. RESULTS: Of the 860 patients analyzed, 64.5% (71.6% in Central Europe and 55.5% in East Asia) were rated as adherent and 35.5% as non-adherent during follow-up. Being from East Asia was found to be a strong predictor of non-adherence. In East Asia, a family history of ADHD and parental emotional distress were associated with non-adherence, while having no other children living at home was associated with non-adherence in Central Europe as well as in the overall sample. Non-adherence was associated with poorer response and less improvement on CGI-ADHD and CSI-4, but not on CHIP-CE. CONCLUSION: Non-adherence to medication is common in the treatment of ADHD, particularly in East Asia. Non-adherence was associated with poorer response and less improvement in clinical severity. A limitation of this study is that medication adherence was assessed by the treating clinician using a single item question.

Avaluació, diagnòstic i intervenció en la dislèxia

En els últims anys, l’aprenentatge de la lectura i les seves dificultats ha estat de gran interès per als educadors i investigadors, propiciant una evolució en el coneixement dels processos implícits en el seu aprenentatge. S’ha arribat a un consens ampli i generalitzat sobre què és la dislèxia i sobre les dificultats que presenta per reconèixer que la consciència fonològica és un dels predictors més fiables del mateix trastorn. A Catalunya, a partir de la LEC (2009), s’han estimulat les actuacions en el sistema educatiu per tal de garantir l’atenció als trastorns d’aprenentatge; en concret, s’ha millorat la formació dels docents i s’han elaborat instruments i materials que facilitin la seva tasca, com ara els protocols de detecció i atenció a l’alumnat amb dislèxia elaborats l’any 2011.El present article se centra en aquest marc i pretén un doble objectiu: (a) orientar i analitzar el procés d’actuació més eficient a l’hora d’avaluar i diagnosticar precoçment la dislèxia, i (b) donar un model perquè, des del marc escolar, es puguin assumir competències i generar procediments per garantir la trajectòria acadèmica dels nens dislèctics i evitar problemes de desajust emocional i social amb el pas del temps.

La psicoanàlisi de Freud sota el microscopi actual

Sigmund Freud (Moràvia, 1856 - Anglaterra, 1939) ha sigut un dels grans pensadors de finals del segle XIX i principis del XX, una figura cabdal de la cultura contemporània. En el seu afany per intentar comprendre la conducta humana, va obrir un camí en l'estudi de la consciència i l'inconscient. Possiblement el seu mèrit més important ha sigut prestar atenció als problemes de salut mental i voler-los acostar a l'àmbit clínic, quan la medicina encara els percebia ben de lluny i els entenia poc. Les seves propostes, però, van ser molt controvertides, i encara ho són avui. Fins i tot entre les persones que estudien el cervell i la ment humana o que apliquen aquests coneixements en la pràctica clínica, encara hi ha desacords profunds pel que fa a la seva validesa i utilitat. Per a alguns, va ser un gran científic que va descobrir importants veritats sobre la psicologia humana; per a d'altres, va ser un filòsof visionari que va replantejar la natura humana, malgrat que les seves hipòtesis no es puguin qualificar de científiques i moltes hagin sigut rebutjades per la neurociència moderna.

Prevalence of Problematic Mobile Phone Use in British Adolescents

The problematic use of mobile phones among adolescents has not been widely studied. There are very few instruments for assessing potential technological addiction to mobile phones, or for categorizing different types of users or uses. The most widely used scale is the Mobile Phone Problem Use Scale (MPPUS), which is used to study adult populations, and has been applied in various forms in international contexts. The aims of this study were to adapt the Spanish version of this scale (MPPUSA) to British adolescents, and then to estimate the prevalence of possible problematic users. A questionnaire was administered to a sample of 1,529 secondary school pupils aged between 11 and 18 years, with 1,026 completed questionnaires being collected. The analysis showed that the factor and construct validity and reliability were comparable to those obtained in previous studies. The prevalence of problematic users among the students was 10%, and the typical problematic user tended to be an adolescent between 11 and 14 years old, studying in a public school, who considered themselves to be an expert user of this technology, who made extensive use of his/her mobile phone, and who attributed the same problem of use among their peers. These users presented notable scores in all the symptoms covered by the scale used to assess problematic use. In conclusion, the adaptation of the MPPUSA as a screening scale for British adolescents presents good sensitivity and specificity for detecting the main addictive symptoms proposed in this validated version.

The use of mixed methods research in the behavioral sciences field

Mixed methods research involves the combined use of quantitative and qualitative methods in the same research study, and it is becoming increasingly important in several scientific areas. The aim of this paper is to review and compare through a mixed methods multiple-case study the application of this methodology in three reputable behavioural science journals: the Journal of Organizational Behavior, Addictive Behaviors and Psicothema. A quantitative analysis was carried out to review all the papers published in these journals during the period 2003-2008 and classify them into two blocks: theoretical and empirical, with the latter being further subdivided into three subtypes (quantitative, qualitative and mixed). A qualitative analysis determined the main characteristics of the mixed methods studies identified, in order to describe in more detail the ways in which the two methods are combined based on their purpose, priority, implementation and research design. From the journals selected, a total of 1.958 articles were analysed, the majority of which corresponded to empirical studies, with only a small number referring to research that used mixed methods. Nonetheless, mixed methods research does appear in all the behavioural science journals studied within the period selected, showing a range of designs, where the sequential equal weight mixed methods research design seems to stand out.

Seguimiento de dependientes del alcohol y/o de la cocaina despues de su salida de una Comunidad Terapeutica: estudio piloto

Introducción Los avances en farmacoterapia del alcoholismo podrían propiciar un cambio de paradigma, basado en los nuevos programas de reducción del consumo de alcohol. Material y Método Este estudio revisa los fundamentos neurobiológicos y farmacoterapéuticos del alcoholismo, centrándose en los antagonistas opioides, el tratamiento orientado a la abstinencia y el orientado hacia la reducción del consumo de alcohol. Resultados 1. Los programas de tratamiento de la dependencia del alcohol presentan sólo una eficacia pequeña o moderada. 2. Los pacientes presentan una elevada motivación para reducir el consumo de alcohol pero una baja motivación para abandonar de manera continuada al consumo de alcohol. 3. El programa de reducción continuada del consumo de alcohol, asociado a un tratamiento intermitente con naltrexona, puede ser de utilidad en los pacientes con una baja gravedad de la dependencia del alcohol. Discusión Aunque los pacientes que presentan una grave dependencia del alcohol deberían ser tratados en programas orientados hacia la abstención continuada, los que presentan una baja gravedad pueden beneficiarse de los programas de reducción del consumo de alcohol, los cuales pueden conseguir a corto plazo una reducción el número de consumiciones por día de consumo y, a largo plazo, incluso una progresiva reducción de la"obsesión" por beber, la conducta de búsqueda de alcohol y los trastornos médicos, conductuales y sociales, causados por el consumo excesivo de alcohol. Para poder llevar a cabo este cambio de paradigma en el tratamiento del alcoholismo, se requieren futuros ensayos clínicos controlados para evaluar su eficacia y su tolerabilidad.

Adaptación española del "Mobile Phone Problematic Use Scale" para población adolescente

El uso problemático del teléfono móvil es un fenómeno emergente en nuestra sociedad, que parece afectar especialmente a la población adolescente. El conocimiento acerca del uso problemático de esta tecnología resulta necesario, dado que puede desarrollarse un patrón comportamental con características adictivas. Apenas existen escalas que midan el posible uso problemático del móvil y ninguna adaptada exclusivamente a población adolescente española. La escala más utilizada internacionalmente es la Mobile Phone Problematic Use Scale (MPPUS). El objetivo de este estudio es adaptar el MPPUS a la población adolescente española. Se administró la versión española del cuestionario a una muestra de 1132 de 12 a 18 años. La fiabilidad y la validez factorial eran comparables a las obtenidas en población adulta, por lo que la medida del uso problemático del móvil en los adolescentes españoles es unidimensional. Se detectó una prevalencia del 14.8% de usuarios problemáticos.