Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd Study)

BACKGROUND: Studies in bipolar disorder (BD) to date are limited in their ability to provide a whole-disease perspective--their scope has generally been confined to a single disease phase and/or a specific treatment. Moreover, most clinical trials have focused on the manic phase of disease, and not on depression, which is associated with the greatest disease burden. There are few longitudinal studies covering both types of patients with BD (I and II) and the whole course of the disease, regardless of patients' symptomatology. Therefore, the Wide AmbispectiVE study of the clinical management and burden of Bipolar Disorder (WAVE-bd) (NCT01062607) aims to provide reliable information on the management of patients with BD in daily clinical practice. It also seeks to determine factors influencing clinical outcomes and resource use in relation to the management of BD. METHODS: WAVE-bd is a multinational, multicentre, non-interventional, longitudinal study. Approximately 3000 patients diagnosed with BD type I or II with at least one mood event in the preceding 12 months were recruited at centres in Austria, Belgium, Brazil, France, Germany, Portugal, Romania, Turkey, Ukraine and Venezuela. Site selection methodology aimed to provide a balanced cross-section of patients cared for by different types of providers of medical aid (e.g. academic hospitals, private practices) in each country. Target recruitment percentages were derived either from scientific publications or from expert panels in each participating country. The minimum follow-up period will be 12 months, with a maximum of 27 months, taking into account the retrospective and the prospective parts of the study. Data on demographics, diagnosis, medical history, clinical management, clinical and functional outcomes (CGI-BP and FAST scales), adherence to treatment (DAI-10 scale and Medication Possession Ratio), quality of life (EQ-5D scale), healthcare resources, and caregiver burden (BAS scale) will be collected. Descriptive analysis with common statistics will be performed. DISCUSSION: This study will provide detailed descriptions of the management of BD in different countries, particularly in terms of clinical outcomes and resources used. Thus, it should provide psychiatrists with reliable and up-to-date information about those factors associated with different management patterns of BD. TRIAL REGISTRATION NO: ClinicalTrials.gov: NCT01062607.

Estudio de caso longitudinal de las creencias sobre el aprendizaje de la lectura y la escritura en la formación inicial de los maestros

Esta comunicación, que presenta el estudio de la evolución de las creencias, representacionesy saberes (en adelante CRS) de una estudiante entre el primer año y el segundo de formaciónuniversitaria, forma parte de un estudio longitudinal más amplio que analiza los CRS de sieteestudiantes del Grado de Maestro de Educación Infantil y ocho del Grado de Maestro de EducaciónPrimaria de la Universitat de Barcelona sobre la enseñanza y el aprendizaje de la lecturay la escritura. El objetivo principal que enmarca la investigación es estudiar en profundidadlos sistemas de CRS para poder comprenderlos, compararlos e identificar los momentos clave de tensión y cambio con el fin de realizar aportaciones que ayuden a mejorar el sistema de formación inicial de los maestros.

Estudio de caso longitudinal de las creencias sobre el aprendizaje de la lectura y la escritura en la formación inicial de los maestros

Esta comunicación, que presenta el estudio de la evolución de las creencias, representacionesy saberes (en adelante CRS) de una estudiante entre el primer año y el segundo de formaciónuniversitaria, forma parte de un estudio longitudinal más amplio que analiza los CRS de sieteestudiantes del Grado de Maestro de Educación Infantil y ocho del Grado de Maestro de EducaciónPrimaria de la Universitat de Barcelona sobre la enseñanza y el aprendizaje de la lecturay la escritura. El objetivo principal que enmarca la investigación es estudiar en profundidadlos sistemas de CRS para poder comprenderlos, compararlos e identificar los momentos clave de tensión y cambio con el fin de realizar aportaciones que ayuden a mejorar el sistema de formación inicial de los maestros.

Pla de gestió de senglars (Sus scrofa) en zones altament antropitzades. Parc Natural de la Serra de Collserola

By studying documents that define the species, as management experiences in Spain and the rest of the world, we have designed a new management plan. This Plan incorporates guidelines for cooperation and networking, as the newest techniques and technologies in the field of wildlife management. During this project, has highlighted the need for a protocol to monitor the effects caused by the animals, in order to define and optimize the actions and resources to use.

Forecasting coal resources and reserves in heterogeneous coal zones using 3D facies models (As Pontes Basin, NW Spain)

Forecasting coal resources and reserves is critical for coal mine development. Thickness maps are commonly used for assessing coal resources and reserves; however they are limited for capturing coal splitting effects in thick and heterogeneous coal zones. As an alternative, three-dimensional geostatistical methods are used to populate facies distributionwithin a densely drilled heterogeneous coal zone in the As Pontes Basin (NWSpain). Coal distribution in this zone is mainly characterized by coal-dominated areas in the central parts of the basin interfingering with terrigenous-dominated alluvial fan zones at the margins. The three-dimensional models obtained are applied to forecast coal resources and reserves. Predictions using subsets of the entire dataset are also generated to understand the performance of methods under limited data constraints. Three-dimensional facies interpolation methods tend to overestimate coal resources and reserves due to interpolation smoothing. Facies simulation methods yield similar resource predictions than conventional thickness map approximations. Reserves predicted by facies simulation methods are mainly influenced by: a) the specific coal proportion threshold used to determine if a block can be recovered or not, and b) the capability of the modelling strategy to reproduce areal trends in coal proportions and splitting between coal-dominated and terrigenousdominated areas of the basin. Reserves predictions differ between the simulation methods, even with dense conditioning datasets. Simulation methods can be ranked according to the correlation of their outputs with predictions from the directly interpolated coal proportion maps: a) with low-density datasets sequential indicator simulation with trends yields the best correlation, b) with high-density datasets sequential indicator simulation with post-processing yields the best correlation, because the areal trends are provided implicitly by the dense conditioning data.

Estudio de caso longitudinal de las creencias sobre el aprendizaje de la lectura y la escritura en la formación inicial de los maestros

Esta comunicación, que presenta el estudio de la evolución de las creencias, representacionesy saberes (en adelante CRS) de una estudiante entre el primer año y el segundo de formaciónuniversitaria, forma parte de un estudio longitudinal más amplio que analiza los CRS de sieteestudiantes del Grado de Maestro de Educación Infantil y ocho del Grado de Maestro de EducaciónPrimaria de la Universitat de Barcelona sobre la enseñanza y el aprendizaje de la lecturay la escritura. El objetivo principal que enmarca la investigación es estudiar en profundidadlos sistemas de CRS para poder comprenderlos, compararlos e identificar los momentos clave de tensión y cambio con el fin de realizar aportaciones que ayuden a mejorar el sistema de formación inicial de los maestros.

Estudio de caso longitudinal de las creencias sobre el aprendizaje de la lectura y la escritura en la formación inicial de los maestros

Esta comunicación, que presenta el estudio de la evolución de las creencias, representacionesy saberes (en adelante CRS) de una estudiante entre el primer año y el segundo de formaciónuniversitaria, forma parte de un estudio longitudinal más amplio que analiza los CRS de sieteestudiantes del Grado de Maestro de Educación Infantil y ocho del Grado de Maestro de EducaciónPrimaria de la Universitat de Barcelona sobre la enseñanza y el aprendizaje de la lecturay la escritura. El objetivo principal que enmarca la investigación es estudiar en profundidadlos sistemas de CRS para poder comprenderlos, compararlos e identificar los momentos clave de tensión y cambio con el fin de realizar aportaciones que ayuden a mejorar el sistema de formación inicial de los maestros.

Determinació de l’estat de seguretat alimentària de dues zones d’Etiòpia i de les variables socioeconòmiques que les afecten

L’objectiu d’aquest estudi ha sigut generar dades especifiques locals de dos zones agroecològiques diferents d’Etiòpia ( el woreda Wukro i el woreda Abaya), mesurar l’estat de seguretat alimentària de la seva població, i els determinants socioeconòmics que els afecten, així com identificar els principals problemes metodològics, interpretatius que afecten a aquestes mesures i, en conseqüència, les intervencions que se’n poden derivar.

Estacions termals en zones rurals, serveis associats i titulacions oficials

El turisme rural, l’esport i la salut han adquirit de forma progressiva en els últims anys una importància cada vegada més gran. Una part creixent de la població ha anat incorporant de mica en mica dies de descans i repòs durant tot l’any. Aquesta realitat és deguda, parcialment, a l’augment del temps lliure i a la consideració del seu gaudi com un element per a la millora de la qualitat de vida. El turisme rural, a causa del canvi de valors experimentat en la societat contemporània, s’interrelaciona amb altres productes, com ara el turisme termal i les activitats esportives realitzades en contacte amb la natura, igual que amb altres serveis del sector del lleure, com ara l’espectacle, el joc, la cultura, etc. Aquesta situació determina la necessitat de plantejar sistemes de gestió professionals i aplicar estratègies que permetin de generar factors competitius i diferenciadors. Les empreses turístiques que han adoptat el paradigma empresarial de la gestió de qualitat total es caracteritzen per oferir qualitat de servei, i per assolir aquesta qualitat cal disposar d’un equip d’especialistes altament qualificats i experimentats. El propòsit d’aquest treball és analitzar les titulacions oficials relacionades amb les estacions termals en zones rurals i els serveis associats.

Interrupció del creixement en la hibernació del gripau corredor (Epidelea calamita) en zones semiàrides

Les particularitats de les poblacions amfíbiques que viuen en zones semiàrides sotmeses a un alt estrès ambiental es posen de manifest mitjançant estudis d’esqueletocronologia. L’estudi pretén avaluar la correlació histològica entre les marques de creixement (lines of arrested growth [LAG]) que es visualitzen en les falanges dels dits i l’edat d’individus de gripau corredor (Epidelea calamita). Existeix una correspondència entre el nombre de LAG i el nombre d’hibernacions, de manera que, en un principi, s’entén cada una de les línies com un any de vida de l’individu. En els resultats trobats mitjançant l’anàlisi dels talls de les falanges, s’aprecien un conjunt de línies múltiples que es consideren com una hibernació interrompuda per petits creixements durant els períodes més càlids de l’hivern i en certa part també per les ocasionals precipitacions. Els resultats obtinguts suggereixen l’existència d’un patró de creixement, en les poblacions d’amfibis en zones semiàrides, diferent de qualsevol altre trobat en amfibis de zones temperades.

Clustering of grape yield maps to delineate site-specific management zones

Zonal management in vineyards requires the prior delineation of stable yield zones within the parcel. Among the different methodologies used for zone delineation, cluster analysis of yield data from several years is one of the possibilities cited in scientific literature. However, there exist reasonable doubts concerning the cluster algorithm to be used and the number of zones that have to be delineated within a field. In this paper two different cluster algorithms have been compared (k-means and fuzzy c-means) using the grape yield data corresponding to three successive years (2002, 2003 and 2004), for a ‘Pinot Noir’ vineyard parcel. Final choice of the most recommendable algorithm has been linked to obtaining a stable pattern of spatial yield distribution and to allowing for the delineation of compact and average sized areas. The general recommendation is to use reclassified maps of two clusters or yield classes (low yield zone and high yield zone) and, consequently, the site-specific vineyard management should be based on the prior delineation of just two different zones or sub-parcels. The two tested algorithms are good options for this purpose. However, the fuzzy c-means algorithm allows for a better zoning of the parcel, forming more compact areas and with more equilibrated zonal differences over time.

Analysis of vineyard differential management zones and relation to vine development, grape maturity and quality

The objective of research was to analyse the potential of Normalized Difference Vegetation Index (NDVI) maps from satellite images, yield maps and grapevine fertility and load variables to delineate zones with different wine grape properties for selective harvesting. Two vineyard blocks located in NE Spain (Cabernet Sauvignon and Syrah) were analysed. The NDVI was computed from a Quickbird-2 multi-spectral image at veraison (July 2005). Yield data was acquired by means of a yield monitor during September 2005. Other variables, such as the number of buds, number of shoots, number of wine grape clusters and weight of 100 berries were sampled in a 10 rows × 5 vines pattern and used as input variables, in combination with the NDVI, to define the clusters as alternative to yield maps. Two days prior to the harvesting, grape samples were taken. The analysed variables were probable alcoholic degree, pH of the juice, total acidity, total phenolics, colour, anthocyanins and tannins. The input variables, alone or in combination, were clustered (2 and 3 Clusters) by using the ISODATA algorithm, and an analysis of variance and a multiple rang test were performed. The results show that the zones derived from the NDVI maps are more effective to differentiate grape maturity and quality variables than the zones derived from the yield maps. The inclusion of other grapevine fertility and load variables did not improve the results.

Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd Study)

BACKGROUND: Studies in bipolar disorder (BD) to date are limited in their ability to provide a whole-disease perspective--their scope has generally been confined to a single disease phase and/or a specific treatment. Moreover, most clinical trials have focused on the manic phase of disease, and not on depression, which is associated with the greatest disease burden. There are few longitudinal studies covering both types of patients with BD (I and II) and the whole course of the disease, regardless of patients' symptomatology. Therefore, the Wide AmbispectiVE study of the clinical management and burden of Bipolar Disorder (WAVE-bd) (NCT01062607) aims to provide reliable information on the management of patients with BD in daily clinical practice. It also seeks to determine factors influencing clinical outcomes and resource use in relation to the management of BD. METHODS: WAVE-bd is a multinational, multicentre, non-interventional, longitudinal study. Approximately 3000 patients diagnosed with BD type I or II with at least one mood event in the preceding 12 months were recruited at centres in Austria, Belgium, Brazil, France, Germany, Portugal, Romania, Turkey, Ukraine and Venezuela. Site selection methodology aimed to provide a balanced cross-section of patients cared for by different types of providers of medical aid (e.g. academic hospitals, private practices) in each country. Target recruitment percentages were derived either from scientific publications or from expert panels in each participating country. The minimum follow-up period will be 12 months, with a maximum of 27 months, taking into account the retrospective and the prospective parts of the study. Data on demographics, diagnosis, medical history, clinical management, clinical and functional outcomes (CGI-BP and FAST scales), adherence to treatment (DAI-10 scale and Medication Possession Ratio), quality of life (EQ-5D scale), healthcare resources, and caregiver burden (BAS scale) will be collected. Descriptive analysis with common statistics will be performed. DISCUSSION: This study will provide detailed descriptions of the management of BD in different countries, particularly in terms of clinical outcomes and resources used. Thus, it should provide psychiatrists with reliable and up-to-date information about those factors associated with different management patterns of BD. TRIAL REGISTRATION NO: ClinicalTrials.gov: NCT01062607.

Dynamic Criteria: a Longitudinal Analysis of Professional Basketball Players" Outcomes

This paper describes the fluctuations of temporal criteria dynamics in the context of professional sport. Specifically, we try to verify the underlying deterministic patterns in the outcomes of professional basketball players. We use a longitudinal approach based on the analysis of the outcomes of 94 basketball players over ten years, covering practically players" entire career development. Time series were analyzed with techniques derived from nonlinear dynamical systems theory. These techniques analyze the underlying patterns in outcomes without previous shape assumptions (linear or nonlinear). These techniques are capable of detecting an intermediate situation between randomness and determinism, called chaos. So they are very useful for the study of dynamic criteria in organizations. We have found most players (88.30%) have a deterministic pattern in their outcomes, and most cases are chaotic (81.92%). Players with chaotic patterns have higher outcomes than players with linear patterns. Moreover, players with power forward and center positions achieve better results than other players. The high number of chaotic patterns found suggests caution when appraising individual outcomes, when coaches try to find the appropriate combination of players to design a competitive team, and other personnel decisions. Management efforts must be made to assume this uncertainty.

Genetic origin of the relationship between parental negativity and behavior problems from early childhood to adolescence: A longitudinal genetically sensitive study.

Little is known about how genetic and environmental factors contribute to the association between parental negativity and behavior problems from early childhood to adolescence. The current study fitted a cross-lagged model in a sample consisting of 4,075 twin pairs to explore (a) the role of genetic and environmental factors in the relationship between parental negativity and behavior problems from age 4 to age 12, (b) whether parent-driven and child-driven processes independently explain the association, and (c) whether there are sex differences in this relationship. Both phenotypes showed substantial genetic influence at both ages. The concurrent overlap between them was mainly accounted for by genetic factors. Causal pathways representing stability of the phenotypes and parent-driven and child-driven effects significantly and independently account for the association. Significant but slight differences were found between males and females for parent-driven effects. These results were highly similar when general cognitive ability was added as a covariate. In summary, the longitudinal association between parental negativity and behavior problems seems to be bidirectional and mainly accounted for by genetic factors. Furthermore, child-driven effects were mainly genetically mediated, and parent-driven effects were a function of both genetic and shared-environmental factors.