El grabado al aguafuerte con sales corrosivas: el legado de los clásicos

El desarrollo industrial y tecnológico del siglo XX ha conllevado un notable incremento y transformación de los lenguajes artísticos, que también ha afectado al grabado, ampliando los recursos de los grabadores de una forma impensable en generaciones anteriores. Recientemente, sin embargo, han aflorado interrogantes y reflexiones acerca de la sostenibilidad de los procedimientos y materiales que se utilizan y se han valorado sus implicaciones en la salud del artista y en el medio ambiente. Algunos de los nuevos métodos y materiales de grabado de bajo riesgo no son tan nuevos, sino que son mejoras y actualizaciones de antiguos métodos utilizados por los grabadores clásicos: la incorporación de mordientes salinos en sustitución de los ácidos en el grabado al aguafuerte ya eran utilizados por los grabadores de los siglos XVI y XVII, y las formulaciones de los mismos las encontramos en los tratados de Benvenuto Cellini, de Abraham Bosse o de Manuel de Rueda, entre otros.

Combination of diffusion tensor and functional magnetic resonance imaging during recovery from the vegetative state

Background: The rate of recovery from the vegetative state (VS) is low. Currently, little is known of the mechanisms and cerebral changes that accompany those relatively rare cases of good recovery. Here, we combined functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) to study the evolution of one VS patient at one month post-ictus and again twelve months later when he had recovered consciousness. Methods fMRI was used to investigate cortical responses to passive language stimulation as well as task-induced deactivations related to the default-mode network. DTI was used to assess the integrity of the global white matter and the arcuate fasciculus. We also performed a neuropsychological assessment at the time of the second MRI examination in order to characterize the profile of cognitive deficits. Results: fMRI analysis revealed anatomically appropriate activation to speech in both the first and the second scans but a reduced pattern of task-induced deactivations in the first scan. In the second scan, following the recovery of consciousness, this pattern became more similar to that classically described for the default-mode network. DTI analysis revealed relative preservation of the arcuate fasciculus and of the global normal-appearing white matter at both time points. The neuropsychological assessment revealed recovery of receptive linguistic functioning by 12-months post-ictus. Conclusions: These results suggest that the combination of different structural and functional imaging modalities may provide a powerful means for assessing the mechanisms involved in the recovery from the VS.

Changes in the phenolic content of low density lipoprotein after olive oil consumption in men. A randomized crossover controlled trial

Olive oil decreases the risk of CVD. This effect may be due to the fatty acid profile of the oil, but it may also be due to its antioxidant content which differs depending on the type of olive oil. In this study, the concentrations of oleic acid and antioxidants (phenolic compounds and vitamin E) in plasma and LDL were compared after consumption of three similar olive oils, but with differences in their phenolic content. Thirty healthy volunteers participated in a placebo-controlled, double-blind, crossover, randomized supplementation trial. Virgin, common, and refined olive oils were administered during three periods of 3 weeks separated by a 2-week washout period. Participants were requested to ingest a daily dose of 25 ml raw olive oil, distributed over the three meals of the day, during intervention periods. All three olive oils caused an increase in plasma and LDL oleic acid (P,0·05) content. Olive oils rich in phenolic compounds led to an increase in phenolic compounds in LDL (P,0·005). The concentration of phenolic compounds in LDL was directly correlated with the phenolic concentration in the olive oils. The increase in the phenolic content of LDL could account for the increase of the resistance of LDL to oxidation, and the decrease of the in vivo oxidized LDL, observed in the frame of this trial. Our results support the hypothesis that a daily intake of virgin olive oil promotes protective LDL changes ahead of its oxidation.

Evaluación de programas de Educación Emocional

Según el art. 1.a de la LOGSE, el sistema educativo se orientará al pleno desarrollo de la personalidad del alumnado. Esto implica atender no solamente al desarrollo cognitivo,sobre el cual hay un énfasis claramente predominante, sino también al desarrollo emocional que lo debe complementar. De las dificultades emocionales pueden derivarse estados de ansiedad, estrés, depresión, consumo de drogas, violencia, conducción temeraria, trastornos de la alimentación, fobia escolar, indisciplina, etc. Diversos trabajos recientes han puesto de manifiesto como el analfabetismo emocional tiene unos efectos altamente negativos sobre las personas y sobre la sociedad (Goleman, 1995). De hecho la mayoría de bajas laborales son debidas a causas relacionadas con las emociones (ansiedad, estrés, depresión); por esta misma causa los medicamentos más consumidos son tranquilizantes, ansiolíticos y antidepresivos, con un elevado coste en la seguridad social. La respuesta educativa a esta necesidad social puede ser la educación emocional.

Las personas mayores ante la crisis económica

La comunicació consisteix en una anàlisi dels efectes de la crisi sobre les persones grans a partir de l’exploració de dades estadístiques i d’un ampli treball de camp qualitatiu fet amb persones grans durant l’any 2013. S’elabora al seu torn una tipologia temptativa d’impactes de la crisi en aquest grup, discutint com s’insereixen aquests canvis en les trajectòries de vida i les xarxes socials de la gent gran, quins són els elements que generen una major vulnerabilitat i, finalment, en quina mesura les alteracions econòmiques produïdes per la crisi es tradueixen també en transformacions en el seu rol econòmic, social i familiar.

Structural Insight into the Mode of Action of a Direct Inhibitor of Coregulator Binding to the Thyroid Hormone Receptor.

The development of nuclear hormone receptor antagonists that directly inhibit the association of the receptor with its essential coactivators would allow useful manipulation of nuclear hormone receptor signaling. We previously identified 3-(dibutylamino)-1-(4-hexylphenyl)-propan-1-one (DHPPA), an aromatic β-amino ketone that inhibits coactivator recruitment to thyroid hormone receptor β (TRβ), in a high-throughput screen. Initial evidence suggested that the aromatic β-enone 1-(4-hexylphenyl)-prop-2-en-1-one (HPPE), which alkylates a specific cysteine residue on the TRβ surface, is liberated from DHPPA. Nevertheless, aspects of the mechanism and specificity of action of DHPPA remained unclear. Here, we report an x-ray structure of TRβ with the inhibitor HPPE at 2.3-Å resolution. Unreacted HPPE is located at the interface that normally mediates binding between TRβ and its coactivator. Several lines of evidence, including experiments with TRβ mutants and mass spectroscopic analysis, showed that HPPE specifically alkylates cysteine residue 298 of TRβ, which is located near the activation function-2 pocket. We propose that this covalent adduct formation proceeds through a two-step mechanism: 1) β-elimination to form HPPE; and 2) a covalent bond slowly forms between HPPE and TRβ. DHPPA represents a novel class of potent TRβ antagonist, and its crystal structure suggests new ways to design antagonists that target the assembly of nuclear hormone receptor gene-regulatory complexes and block transcription.

Evaluación de las curvaturas locales de un frente de onda mediante interferometria de difracción por múltiples puntos

El objetivo fundamental de este trabajo es modificar el diseño clásico del interferómetro de difracción por punto para que permita medir simultáneamente las curvaturas locales de la fase de una onda en distintos puntos de un plano transversal a la dirección de propagación de un haz de luz con aberraciones. Para ello, y como segundo objetivo, propondremos un método de cálculo nuevo y sencillo que nos permitirá diseñar el componente fundamental del interferómetro para cada aplicación deseada.

Anàlisis antropològica de les restes neolítiques de la Caserna de Sant Pau (Biometria, Dentició, ADN i Microestriació Dentària).

Les restes esquelètiques analitzades corresponen tant al nivell neolític (n=26) com a l"època del bronze (n=2), encara que aquí es presenten tan sols els resultats de la població neolítica (taula 1). En tots els casos les sepultures són individuals, amb l"única excepció de la sepultura 20, on s"han recuperat les restes corresponents a un individu femení adult (CSP201) i un fetus (CSP202) (taula 1). Per tal de caracteritzar biomètricament la població s"ha emprat la metodologia proposada per Martin i Saller (1959), Brothwell (1981) i Bass (1971). La determinació del sexe s"ha realitzat a través dels caràcters sexuals secundaris del crani i de la pelvis, i se"n pot trobar una descripció més detallada a Estebaranz et alii (2007). En el cas específic de les paleopatologies es van seguir les recomanacions de Campillo (Campillo, 1977).

Allosteric conversation in the androgen receptor ligand-binding domain surfaces

Androgen receptor (AR) is a major therapeutic target that plays pivotal roles in prostate cancer (PCa) and androgen insensitivity syndromes. We previously proposed that compounds recruited to ligand-binding domain (LBD) surfaces could regulate AR activity in hormone-refractory PCa and discovered several surface modulators of AR function. Surprisingly, the most effective compounds bound preferentially to a surface of unknown function [binding function 3 (BF-3)] instead of the coactivator-binding site [activation function 2 (AF-2)]. Different BF-3 mutations have been identified in PCa or androgen insensitivity syndrome patients, and they can strongly affect AR activity. Further, comparison of AR x-ray structures with and without bound ligands at BF-3 and AF-2 showed structural coupling between both pockets. Here, we combine experimental evidence and molecular dynamic simulations to investigate whether BF-3 mutations affect AR LBD function and dynamics possibly via allosteric conversation between surface sites. Our data indicate that AF-2 conformation is indeed closely coupled to BF-3 and provide mechanistic proof of their structural interconnection. BF-3 mutations may function as allosteric elicitors, probably shifting the AR LBD conformational ensemble toward conformations that alter AF-2 propensity to reorganize into subpockets that accommodate N-terminal domain and coactivator peptides. The induced conformation may result in either increased or decreased AR activity. Activating BF-3 mutations also favor the formation of another pocket (BF-4) in the vicinity of AF-2 and BF-3, which we also previously identified as a hot spot for a small compound. We discuss the possibility that BF-3 may be a protein-docking site that binds to the N-terminal domain and corepressors. AR surface sites are attractive pharmacological targets to develop allosteric modulators that might be alternative lead compounds for drug design.

Ironías de la ironía: argumento dialéctico, figura retórica o categoría estética

[spa] El artículo plantea una breve revisión de la idea de ironía desde el punto de vista de la retórica y sus derivaciones en algunos de los estudios lingüísticos del siglo XX. Se parte de la clasificación tradicional de la ironía socrática, la ironía retórica y la ironía romántica para centrar el análisis en aspectos básicos del fenómeno irónico tales como la oposición, la verosimilitud, la complicidad con el intérprete o el papel desempeñado por el contexto. [eng] This article is a brief review of the concept of irony from the point of view of rhetoric and its influences in some of the twentieth century linguistic studies. The review begins with the traditional classification of Socratic irony, rhetoric irony and romantic irony in order to focus the analysis on some fundamental elements of ironic phenomenon such as opposition, verisimilitude, camaraderie with the interpreter or the role played by the context.

Pego do Diabo (Loures, Portugal): Dating the Emergence of Anatomical Modernity in Westernmost Eurasia

Neandertals and the Middle Paleolithic persisted in the Iberian Peninsula south of the Ebro drainage system for several millennia beyond their assimilation/replacement elsewhere in Europe. As only modern humans are associated with the later stages of the Aurignacian, the duration of this persistence pattern can be assessed via the dating of diagnostic occurrences of such stages.

Análisis estadístico de la litigiosidad en los Tribunales Económico-Administrativos Regionales y Central

El presente artículo versa sobre la litigiosidad acaecida en los Tribunales Económico Administrativos Regionales y Locales, así como en el Tribunal Económico Administrativo Central, a cuyo fin se lleva a cabo una visión comparada de la conflictividad tributaria observada en las diferentes Comunidades Autónomas, con especial incidencia en los T.E.A.R.s de las Comunidades de Andalucía, Madrid, Cataluña y Valencia. Dedicamos la segunda parte del estudio a la litigiosidad registrada en el Tribunal Económico-Administrativo Central.