Maslinic acid-enriched diet decreases intestinal tumorigenesis in ApcMin/+ mice through transcriptomic and metabolomic reprogramming

Chemoprevention is a pragmatic approach to reduce the risk of colorectal cancer, one of the leading causes of cancerrelated death in western countries. In this regard, maslinic acid (MA), a pentacyclic triterpene extracted from wax-like coatings of olives, is known to inhibit proliferation and induce apoptosis in colon cancer cell lines without affecting normal intestinal cells. The present study evaluated the chemopreventive efficacy and associated mechanisms of maslinic acid treatment on spontaneous intestinal tumorigenesis in ApcMin/+ mice. Twenty-two mice were randomized into 2 groups: control group and MA group, fed with a maslinic acid-supplemented diet for six weeks. MA treatment reduced total intestinal polyp formation by 45% (P,0.01). Putative molecular mechanisms associated with suppressing intestinal polyposis in ApcMin/+ mice were investigated by comparing microarray expression profiles of MA-treated and control mice and by analyzing the serum metabolic profile using NMR techniques. The different expression phenotype induced by MA suggested that it exerts its chemopreventive action mainly by inhibiting cell-survival signaling and inflammation. These changes eventually induce G1-phase cell cycle arrest and apoptosis. Moreover, the metabolic changes induced by MA treatment were associated with a protective profile against intestinal tumorigenesis. These results show the efficacy and underlying mechanisms of MA against intestinal tumor development in the ApcMin/+ mice model, suggesting its chemopreventive potential against colorectal cancer.

Buenas prácticas textuales e interpretabilidad de la letra pequeña

El examen de una normativa para mejorar la información al consumidor plantea observaciones pragmáticas sobre buenas prácticas textuales. La orden 385/2003 de la Generalitat de Catalunya establece el tamaño mínimo de la letra en contratos para facilitar su legibilidad. La interpretación de esta normativa permite considerar el uso pragmático de la letra pequeña. Y se recoge también el ejemplo publicitario de una empresa energética que paradójicamente utiliza, en la actualidad, como recurso de prestigio la letra pequeña en documentos contractuales. GOOD TEXTUAL PRACTICES AND INTERPRETABILITY OF THE FINE PRINT IN CONTRACTS. The review of legislation to improve consumer information raises pragmatic observations on textual practices. The order 385/2003 of the Autonomous Government of Catalonia (Spain) sets the minimum font size in contracts for readability. The interpretation of these rules allows us to consider the pragmatic use of the fine print. And the paper also includes advertising from an energy company that paradoxically used as a resource for prestige the fine print in contract documents.

Identity, non-identity, and near-identity: Addressing the complexity of coreference

This article examines the mainstream categorical definition of coreference as "identity of reference." It argues that coreference is best handled when identity is treated as a continuum, ranging from full identity to non-identity, with room for near-identity relations to explain currently problematic cases. This middle ground is needed to account for those linguistic expressions in real text that stand in relations that are neither full coreference nor non-coreference, a situation that has led to contradictory treatment of cases in previous coreference annotation efforts. We discuss key issues for coreference such as conceptual categorization, individuation, criteria of identity, and the discourse model construct. We redefine coreference as a scalar relation between two (or more) linguistic expressions that refer to discourse entities considered to be at the same granularity level relevant to the linguistic and pragmatic context. We view coreference relations in terms of mental space theory and discuss a large number of real life examples that show near-identity at different degrees.

Beyond pure public and pure private management models: Partial privatization in the European airport industry

The use of private funding and management is enjoying an increasing trend in airports. The literature has not paid enough attention to the mixed management models in this industry, although many European airports take the form of mixed public-private companies, where ownership is shared between public and private sectors. We examine the determinants of the degree of private participation in the European airport sector. Drawing on a sample of the 100 largest European airports, we estimate a multivariate equation in order to determine the role of airport characteristics, fiscal variables, and political factors on the extent of private involvement. Our results confirm the alignment between public and private interests in partially privatized airports. Fiscal constraints and market attractiveness promote private participation. Integrated governance models and the share of network carriers prevent the presence of private ownership, while the degree of private participation appears to be pragmatic rather than ideological.

Beyond pure public and pure private management models: Mixed firms in the European Airport Industry

The use of private funding and management enjoys an increasing trend in airports. The literature has not paid enough attention to the mixed management models in this industry, although many European airports take the form of mixed firms or Institutional PPP, where ownership is shared between public and private sectors. We examine the determinants of the degree of private participation in the European airport sector. Drawing on a sample of the 100 largest European airports we estimate a multivariate equation in order to determine the role of airport characteristics, fiscal variables and political factors on the extent of private involvement. Our results confirm the alignment between public and private interests in PPPs. Fiscal constraints and market attractiveness promote private participation. Integrated governance models and the share of network carriers prevent the presence of private ownership, while the degree of private participation appears to be pragmatic rather than ideological.

La Relación del lenguaje con la teoría de la mente en edad escolar

In the past years a considerable amount of research has been carried out on the development of theory of mind (ToM) reporting that language and ToM performance are correlated. However it is less clear what aspect of language is related with ToM development. Some studies show a greater influence of semantics aspects, whereas others suggest that sentential complement sentences, a specific aspect of syntax, are crucial for false belief understanding (FB). Yet others argue that pragmatic abilities correlate with FB understanding. The aim of this study is investigate, on the one side, the development of ToM between the ages of 6 and 8 and on the other side, the relationship between some aspects of language and the ToM improvement. Several ToM tasks were administrated to evaluate children’s performance at two different ages (60 participants aged 6 and 8 years) and four tasks to assess language abilities. The results show a significant increase in the understanding of the mind between the ages of 6 and 8. Furthermore, results reveal a significant relationship between syntax and tasks that require FB understanding, while pragmatics is more strongly associated with tasks that involve more complex socio-cognitive understandings

Identidad, percepción de vitalidad etnolingüística y comunicación intergrupal en Cataluña: An identity and ethnolinguistic perception vitality study in Catalonia

Catalan has drawn considerable attention given its impressive institutional support and increased usage since the restoration of the Generalitat of Catalonia. We report a study on 112 Catalan-speaking students who were administered the"subjective vitality questionnaire". Results show (and these are compared with reports 20 years ago) that it continues to gain momentum and status, even with the International stature of Spanish. The theoretical and pragmatic significance of these findings are discussed in terms of vitality"s role in shaping Language choices (Catalan vs. Castilian) in everyday communication as well as the societal level in forging Language policies for communicating in Catalan in business, political, educational, and media arenas

Liderazgo y dirección de empresas en el s. XXI

Peer-reviewed

La construcción narrativa de la identidad a través del conflicto y la ventrilocuación

El objetivo del siguiente trabajo es analizar el discurso de indígenas y mestizos a partir de una perspectiva pragmática. En particular, vamos a explorar la idea de que estos discursos están constituidos por muchas voces. En otras palabras, se muestra la polifonía, para utilizar una idea de Bakhtin. Según este enfoque, la identidad se desarrolla a través de la integración de voces ajenas que se produce a través de narraciones. En este sentido, la identidad surge de rellenar con la propia intención las palabras de los demás. Siguiendo la etnografía de la comunicación nuestra unidad de análisis es el acto de habla (el acto de significado) que se produce en un contexto. Sugerimos que la ventrilocuación de las ideas de otras personas y los conflictos son temas relevantes para el estudio de la construcción narrativa de la identidad.

Los Sufijos apreciativos en la enseñanza de ELE

El principal objetivo de este trabajo es realizar una pequeña aportación a la enseñanza/aprendizaje del español como lengua extranjera. La finalidad es que pueda servir tanto a profesores como a alumnos, ofreciendo una exposición de la sufijación apreciativa no solo como un aspecto más dentro de la gramática, sino concediendo al alumno una serie de estrategias que le ayuden a favorecer un aprendizaje reflexivo de la gramática y, en particular, de la formación de palabras. Todo esto unido siempre a aspectos socioculturales, pragmáticos, e incluso relacionados con el elemento intercultural

Anàlisi de l’ús del català en l’àmbit del turisme

El primer objectiu d’aquest treball és analitzar el llenguatge del turisme a la ciutat de Girona en temporada alta (juliol i agost) en un sentit pragmàtic. En aquest treball ens centrarem en una anàlisi del llenguatge turístic des del punt de vista de les situacions comunicatives on és utilitzat. El segon objectiu és conèixer l’opinió dels turistes sobre la llengua catalana mitjançant una enquesta feta a dos-cents turistes

Concluding Remarks on River Conservation

We have pragmatic and ethical obligations to conserve rivers and their biodiversity. This chapter outlines how and why river conservation is important. To make a difference, we must act as individuals and groups, using water wisely and protecting vulnerable assets such as water quality, riparian zones and aquatic biodiversity

Comprehension of passives in Persian speaking children with ASD : an investigation of grammar in autism

Most research on the underlying causes of social and communicative impairment in autism spectrum disorders (ASD) has been devoted to pragmatic aspects of language. The present research is exploring the syntactic knowledge as a probable underlying mechanism of language deficit in ASD. Three groups comprising high-functioning ASD, low-functioning ASD, and typically developing 5-year-old Persian-speaking children were tested on comprehension of passive sentences. Results suggest that while low-functioning children with ASD might be impaired in the area of grammar, high-functioning children with ASD are not. The new results are compared to those of two recent studies on comprehension of passives in Greek-speaking and English-speaking subjects with ASD (Perovic et al., 2007; Terzi, et al., to appear).

Cómo construimos el mundo: relativismo, espacios de relación y narratividad

Este artículo aborda la construcción narrativa del mundo desde una aproximación psicosocial socioconstruccionista que tiene en su punto de mira la acción social y su carácter dilemático y político. El texto plantea el carácter construido y constructor de la narración en las prácticas comunicativas. En este sentido, tiene un papel fundamental la consideración de la narrativa como dispositivo donde se entrecruzan la dimensión relativista, su creación en la acción conjunta y su carácter pragmático