Criterios de selección de proveedores de tecnologías de la información y comunicaciones en el sector financiero : Consecuencias de su aplicación y estudio de un caso real

Peer-reviewed

Alvaro Cunqueiro, Néstor Luján y familia

El objetivo de este artículo es documentar y fechar con detalle las relaciones de Cunqueiro con intelectuales catalanes destacados en las décadas de 1950 y 1960 a partir de textos memorialísticos, noticias conservadas en las hemerotecas y testimonios del propio autor. De esta manera se puede establecer la cronología de estos contactos así como seguir la recepción de la obra y de la personalidad de Cunqueiro en la prensa catalana.

Swarm Intelligent Selection and Optimization of Machining System Parameters for Microchannel Fabrication in Medical Devices

Current technology trends in medical device industry calls for fabrication of massive arrays of microfeatures such as microchannels on to nonsilicon material substrates with high accuracy, superior precision, and high throughput. Microchannels are typical features used in medical devices for medication dosing into the human body, analyzing DNA arrays or cell cultures. In this study, the capabilities of machining systems for micro-end milling have been evaluated by conducting experiments, regression modeling, and response surface methodology. In machining experiments by using micromilling, arrays of microchannels are fabricated on aluminium and titanium plates, and the feature size and accuracy (width and depth) and surface roughness are measured. Multicriteria decision making for material and process parameters selection for desired accuracy is investigated by using particle swarm optimization (PSO) method, which is an evolutionary computation method inspired by genetic algorithms (GA). Appropriate regression models are utilized within the PSO and optimum selection of micromilling parameters; microchannel feature accuracy and surface roughness are performed. An analysis for optimal micromachining parameters in decision variable space is also conducted. This study demonstrates the advantages of evolutionary computing algorithms in micromilling decision making and process optimization investigations and can be expanded to other applications

Mejora de las competencias profesionales de los estudiantes del Grado de Farmacia de la Universidad de Barcelona

La implementación del sistema universitario español en el Espacio Europeo de Educación Superior (EEES) ha implicado una serie de cambios en los Grados universitarios. Entre estos se encuentra el balancear la formación teórica con la práctica, de manera que los alumnos acaben con una formación óptima para afrontar su futuro laboral con elevadas posibilidades de éxito. A nivel estatal y de la Universidad de Barcelona se realizaron los cambios legales necesarios para enmarcar estos periodos de prácticas.1 El Grado de Farmacia contaba con la realización de un periodo de prácticas tuteladas obligatorias dentro del ámbito asistencial que se realizan en farmacias y hospitales. En este sentido el ámbito de industria quedaba marginado en el grado. Para subsanar esta deficiencia y para adecuar el grado al EEES, en el año 2012 se incorporó en el plan de estudios de Farmacia una asignatura optativa que se denominó “Prácticas en empresa”.

Mejora de las competencias profesionales de los estudiantes del Grado de Farmacia de la Universidad de Barcelona

La implementación del sistema universitario español en el Espacio Europeo de Educación Superior (EEES) ha implicado una serie de cambios en los Grados universitarios. Entre estos se encuentra el balancear la formación teórica con la práctica, de manera que los alumnos acaben con una formación óptima para afrontar su futuro laboral con elevadas posibilidades de éxito. A nivel estatal y de la Universidad de Barcelona se realizaron los cambios legales necesarios para enmarcar estos periodos de prácticas.1 El Grado de Farmacia contaba con la realización de un periodo de prácticas tuteladas obligatorias dentro del ámbito asistencial que se realizan en farmacias y hospitales. En este sentido el ámbito de industria quedaba marginado en el grado. Para subsanar esta deficiencia y para adecuar el grado al EEES, en el año 2012 se incorporó en el plan de estudios de Farmacia una asignatura optativa que se denominó “Prácticas en empresa”.

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation

Lipid overload in obesity and type 2 diabetes is associated with adipocyte dysfunction, inflammation, macrophage infiltration, and decreased fatty acid oxidation (FAO). Here, we report that the expression of carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme in mitochondrial FAO, is higher in human adipose tissue macrophages than in adipocytes and that it is differentially expressed in visceral vs. subcutaneous adipose tissue in both an obese and a type 2 diabetes cohort. These observations led us to further investigate the potential role of CPT1A in adipocytes and macrophages. We expressed CPT1AM, a permanently active mutant form of CPT1A, in 3T3-L1 CARΔ1 adipocytes and RAW 264.7 macrophages through adenoviral infection. Enhanced FAO in palmitate-incubated adipocytes and macrophages reduced triglyceride content and inflammation, improved insulin sensitivity in adipocytes, and reduced endoplasmic reticulum stress and ROS damage in macrophages. We conclude that increasing FAO in adipocytes and macrophages improves palmitate-induced derangements. This indicates that enhancing FAO in metabolically relevant cells such as adipocytes and macrophages may be a promising strategy for the treatment of chronic inflammatory pathologies such as obesity and type 2 diabetes.

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation

Lipid overload in obesity and type 2 diabetes is associated with adipocyte dysfunction, inflammation, macrophage infiltration, and decreased fatty acid oxidation (FAO). Here, we report that the expression of carnitine palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme in mitochondrial FAO, is higher in human adipose tissue macrophages than in adipocytes and that it is differentially expressed in visceral vs. subcutaneous adipose tissue in both an obese and a type 2 diabetes cohort. These observations led us to further investigate the potential role of CPT1A in adipocytes and macrophages. We expressed CPT1AM, a permanently active mutant form of CPT1A, in 3T3-L1 CARΔ1 adipocytes and RAW 264.7 macrophages through adenoviral infection. Enhanced FAO in palmitate-incubated adipocytes and macrophages reduced triglyceride content and inflammation, improved insulin sensitivity in adipocytes, and reduced endoplasmic reticulum stress and ROS damage in macrophages. We conclude that increasing FAO in adipocytes and macrophages improves palmitate-induced derangements. This indicates that enhancing FAO in metabolically relevant cells such as adipocytes and macrophages may be a promising strategy for the treatment of chronic inflammatory pathologies such as obesity and type 2 diabetes.

Expressional regulation of key hepatic enzymes of intermediary metabolism in European seabass (Dicentrarchus labrax) during food deprivation and refeeding

We hypothesized that the analysis of mRNA level and activity of key enzymes in amino acid and carbohydrate metabolism in a feeding/fasting/refeeding setting could improve our understanding of how a carnivorous fish, like the European seabass (Dicentrarchus labrax), responds to changes in dietary intake at the hepatic level. To this end cDNA fragments encoding genes for cytosolic and mitochondrial alanine aminotransferase (cALT; mALT), pyruvate kinase (PK), glucose 6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) were cloned and sequenced. Measurement of mRNA levels through quantitative real-time PCR performed in livers of fasted seabass revealed a significant increase in cALT (8.5-fold induction)while promoting a drastic 45-fold down-regulation of PK in relation to the levels found in fed seabass. These observations were corroborated by enzyme activity meaning that during food deprivation an increase in the capacity of pyruvate generation happened via alanine to offset the reduction in pyruvate derived via glycolysis. After a 3-day refeeding period cALT returned to control levels while PK was not able to rebound. No alterations were detected in the expression levels of G6PDH while 6PGDH was revealed to be more sensitive specially to fasting, as confirmed by a significant 5.7-fold decrease in mRNA levels with no recovery after refeeding. Our results indicate that in early stages of refeeding, the liver prioritized the restoration of systemic normoglycemia and replenishment of hepatic glycogen. In a later stage, once regular feeding is re-established, dietary fuel may then be channeled to glycolysis and de novo lipogenesis.

Expressional regulation of key hepatic enzymes of intermediary metabolism in European seabass (Dicentrarchus labrax) during food deprivation and refeeding

We hypothesized that the analysis of mRNA level and activity of key enzymes in amino acid and carbohydrate metabolism in a feeding/fasting/refeeding setting could improve our understanding of how a carnivorous fish, like the European seabass (Dicentrarchus labrax), responds to changes in dietary intake at the hepatic level. To this end cDNA fragments encoding genes for cytosolic and mitochondrial alanine aminotransferase (cALT; mALT), pyruvate kinase (PK), glucose 6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) were cloned and sequenced. Measurement of mRNA levels through quantitative real-time PCR performed in livers of fasted seabass revealed a significant increase in cALT (8.5-fold induction)while promoting a drastic 45-fold down-regulation of PK in relation to the levels found in fed seabass. These observations were corroborated by enzyme activity meaning that during food deprivation an increase in the capacity of pyruvate generation happened via alanine to offset the reduction in pyruvate derived via glycolysis. After a 3-day refeeding period cALT returned to control levels while PK was not able to rebound. No alterations were detected in the expression levels of G6PDH while 6PGDH was revealed to be more sensitive specially to fasting, as confirmed by a significant 5.7-fold decrease in mRNA levels with no recovery after refeeding. Our results indicate that in early stages of refeeding, the liver prioritized the restoration of systemic normoglycemia and replenishment of hepatic glycogen. In a later stage, once regular feeding is re-established, dietary fuel may then be channeled to glycolysis and de novo lipogenesis.

Cómo construimos el mundo: relativismo, espacios de relación y narratividad

Este artículo aborda la construcción narrativa del mundo desde una aproximación psicosocial socioconstruccionista que tiene en su punto de mira la acción social y su carácter dilemático y político. El texto plantea el carácter construido y constructor de la narración en las prácticas comunicativas. En este sentido, tiene un papel fundamental la consideración de la narrativa como dispositivo donde se entrecruzan la dimensión relativista, su creación en la acción conjunta y su carácter pragmático

Escena col·lectiva transdisciplinària : una aproximació didàctica a l'aula de música

La transdisciplinarietat no és un fenomen nou, però la seva aplicació real en els camps artístics i educatius no té el seguiment ni la justificació que mereix. Aquest TFG analitza una proposta de creació col·lectiva transdisciplinària dins de l’àmbit de l’educació superior artística que pot servir de model per a aplicacions posteriors en altres àmbits.