12 resultados para Mercury film electrode
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Advanced Materials, Vol. 17, nº 5
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Thin Solid Films, vol. 427, nº 1-2
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Applied Physics Letters, 89
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Quimica Nova, Vol. 32, Nº2
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In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Nanotechnologies and Nanosciences by Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia
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Dissertação para obtenção do Grau de Mestre em Engenharia Biomédica
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J Biol Inorg Chem (2011) 16:209–215 DOI 10.1007/s00775-010-0717-z
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Dissertação para obtenção do Grau de Doutor em Nanotecnologia e Nanociência
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Dissertação para obtenção do Grau de Mestre em Biotecnologia
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Understanding how the brain works will require tools capable of measuring neuron elec-trical activity at a network scale. However, considerable progress is still necessary to reliably increase the number of neurons that are recorded and identified simultaneously with existing mi-croelectrode arrays. This project aims to evaluate how different materials can modify the effi-ciency of signal transfer from the neural tissue to the electrode. Therefore, various coating materials (gold, PEDOT, tungsten oxide and carbon nano-tubes) are characterized in terms of their underlying electrochemical processes and recording ef-ficacy. Iridium electrodes (177-706 μm2) are coated using galvanostatic deposition under different charge densities. By performing electrochemical impedance spectroscopy in phosphate buffered saline it is determined that the impedance modulus at 1 kHz depends on the coating material and decreased up to a maximum of two orders of magnitude for PEDOT (from 1 MΩ to 25 kΩ). The electrodes are furthermore characterized by cyclic voltammetry showing that charge storage capacity is im-proved by one order of magnitude reaching a maximum of 84.1 mC/cm2 for the PEDOT: gold nanoparticles composite (38 times the capacity of the pristine). Neural recording of spontaneous activity within the cortex was performed in anesthetized rodents to evaluate electrode coating performance.