Structural and functional studies of PpcA: a key protein in the electron transfer pathways of Geobacter sulfurreducens

Disserta����o para obten����o do Grau de Doutor em Bioqu��mica, ramo de Biotecnologia

N��s callcentristas somos o novo proletariado. Identidades e resist��ncias do trabalho em call center

Disserta����o de mestrado em Antropologia - Direitos Humanos e Movimentos Sociais

How to attract central and Northeneuropeans to a rural tourism establishment in the center of Portugal

A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA ��� School of Business and Economics

Selection of a co-operation agreement between EMOVE ��� Innovative Technologies and WavEC ��� Wave Energy Center

A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA ��� School of Business and Economics

Validation of NASA rotor 67 with openFOAM's transonic density-based solver

Disserta����o para obten����o do Grau de Mestre em Engenharia Mec��nica

Business development in Siemens global shared services delivery center Portugal

A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA ��� School of Business and Economics

Improving contact center cost efficiency and customer experience in a retail company

A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA ��� School of Business and Economics

Guincho surf center business plan viability: Case study

A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA ��� School of Business and Economics

Marketing plan for Educational Center "The Unknow Islands" Russia

A Work Project, presented as part of the requirements for the Award of a Masters Degree in Management from the NOVA ��� School of Business and Economics

Aterragem de rob��s a��reos multi-rotor em plataformas m��veis: uma solu����o baseada em comportamentos e em sali��ncia visual

Disserta����o para obten����o do Grau de Mestre em Engenharia Eletrot��cnica e de Computadores

Estudo do motor em disco com o rotor em alum��nio e em supercondutor multi-semente

Nesta disserta����o �� realizado o estudo de um motor em disco polif��sico com armadura convencional e rotor que pode ser convencional, em alum��nio, ou composto por material supercondutor de alta temperatura multi���semente. O motor com o rotor em alum��nio apresenta um comportamento ass��ncrono bem definido, baseado na lei geral de indu����o de eletromotrizes no induzido. Contudo, ao ser mergulhado em azoto l��quido, evidencia melhores caracter��sticas el��ctricas, tanto do induzido como do indutor, mesmo que o n��cleo ferromagn��tico convencional possa exibir degrada����o magn��tica. O motor com o rotor SAT exibe um comportamento distinto, evidenciando ambos os regimes s��ncrono e ass��ncrono est��veis. O regime s��ncrono fica caracterizado pelo fen��meno de aprisionamento de campo, que garante que o rotor gire s��ncrono com o campo girante do estator. Em regime ass��ncrono, para um determinado valor de bin��rio resistente aplicado superior ao electromagn��tico m��ximo desenvolvido pelo motor, o fen��meno de escoamento de campo est�� presente, sendo o bin��rio electromagn��tico motor refor��ado por um bin��rio extra de perdas de car��cter resistivo desenvolvidas no rotor devido �� interac����o da densidade de corrente a campos el��ctricos que se estabelecem no rotor. Neste caso, o fen��meno de escoamento de campo n��o �� devido a for��as de Lorentz que se definem na matriz de Abrikosov, mas sim devido a esta ser ���puxada��� pelo campo girante do estator, ficando a matriz a deslizar sobre o rotor. De modo a obter as caracter��sticas dos sistemas electromec��nicos em estudo �� realizada uma an��lise te��rica, baseada na teoria convencional das m��quinas el��ctricas, com o objectivo de compreender alguns dos fen��menos do motor de fluxo axial, e uma an��lise baseada num programa comercial de elementos finitos onde o fen��meno da supercondutividade �� simulado com base na rela����o entre o campo el��trico e a densidade de corrente pela lei da potencia����o (E���J power law). O ensaio dos motores referidos �� realizado para comparar ambos os sistemas e de real��ar o princ��pio de funcionamento e as caracter��sticas mais relevantes de cada um. Da an��lise realizada �� desenvolvido um modelo que caracteriza o funcionamento da m��quina com o rotor com SAT.

Increasing sales volume in mass business through inbound contact center

Field lab: Consulting lab

Application of superconducting bulks and stacks of tapes in electrical machines

The present dissertation focuses on the research of the recent approach of innovative high-temperature superconducting stacked tapes in electrical ma-chines applications, taking into account their potential benefits as an alternative for the massive superconducting bulks, mainly related with geometric and me-chanical flexibility. This work was developed in collaboration with Institut de Ci��ncia de Ma-terials de Barcelona (ICMAB), and is related with evaluation of electrical and magnetic properties of the mentioned superconducting materials, namely: analysis of magnetization of a bulk sample through simulations carried out in the finite elements COMSOL software; measurement of superconducting tape resistivity at liquid nitrogen and room temperatures; and, finally, development and testing of a frequency controlled superconducting motor with rotor built by superconducting tapes. In the superconducting state, results showed a critical current density of 140.3 MA/m2 (or current of 51.15 A) on the tape and a 1 N���m developed motor torque, independent from the rotor position angle, typical in hysteresis motors.

Chitosan-based magnetic nanoparticles for osteosarcoma theranostic

Cancer is a well-known disease with a significant impact in society not only due to its incidence, more evident in more developed countries, but also due to the expenses related to medical treat-ments. Cancer research is considered an increasingly logical science with great potential for the development of new treatment options. Advances in nanomedicine have resulted in rapid devel-opment of nanomaterials with considerable potential in cancer diagnostics and treatment. The combination of diagnosis and treatment in a single nano-platform is named theranostic. In this PhD thesis a theranostic system for osteosarcoma was proposed, composed by a magnetic core, a polymeric coating, and a chemotherapeutic drug. The presence of a specific targeting agent, in this case a monoclonal antibody, provides high specificity to the proposed theranostic system. For the core of the proposed theranostic system, stable aqueous suspensions of superparamagnetic iron oxide nanoparticles with an average diameter of 9 nm were produced. Chitosan-based poly-meric nanoparticles with a hydrodynamic diameter around 150 nm were successfully produced. Incorporation of iron oxide nanoparticles into the polymeric ones increased their hydrodynamic diameter to at least 250 nm. A monoclonal antibody specific for a transmembranar protein (car-bonic anhydrase IX) present in solid tumors was developed by hybridoma technology. Functional hybridomas producing the desired monoclonal antibodies were obtained. The proposed theranostic system functionality was evaluated in separated parts of its components. Uncoated and coated iron oxide nanoparticles with chitosan-based polymers generated heat under the application of an external alternating magnetic field. Uncoated iron oxide nanoparticles sta-bilized with oleic acid were able to enhance contrast in magnetic resonance imaging. Drug deliv-ery studies were conducted in chitosan-based polymeric nanoparticles without and with the in-corporation of iron oxide nanoparticles, demonstrating to be an effective drug delivery platform for doxorubicin. The theranostic system proposed in this PhD thesis is very promising for cancer theranostic, demonstrating to be applicable in solid tumors such as osteosarcoma.