Caracteriza����o qu��mica de contas de vidro arqueol��gicas do s��culo VII a.C. provenientes da Quinta do Almaraz, Cacilhas

Disserta����o para obten����o do Grau de Mestre em Ci��ncias da Conserva����o, Departamento de Conserva����o e Restauro

Analysis of the activation mechanism of Pseudomonas stutzeri cytochrome c peroxidase through an electron transfer chain

J Biol Inorg Chem (2011) 16:881���888 DOI 10.1007/s00775-011-0785-8

Artefacts induced on c-type haem proteins by electrode surfaces

J Biol Inorg Chem (2011) 16:209���215 DOI 10.1007/s00775-010-0717-z

Kinetic, Structural, and EPR Studies Reveal That Aldehyde Oxidoreductase from Desulfovibrio gigas Does Not Need a Sulfido Ligand for Catalysis and Give Evidence for a Direct Mo-C Interaction in a Biological System

J. Am. Chem. Soc., 2009, 131 (23), pp 7990���7998 DOI: 10.1021/ja809448r

Benefits of membrane electrodes in the electrochemistry of metalloproteins: mediated catalysis of Paracoccus pantotrophus cytochrome c peroxidase by horse cytochrome c: a case study

J Biol Inorg Chem. 2008 Jun;13(5):779-87. doi: 10.1007/s00775-008-0365-8

Mediated catalysis of Paracoccus pantotrophus cytochrome c peroxidase by P. pantotrophus pseudoazurin: kinetics of intermolecular electron transfer

J Biol Inorg Chem (2007) 12:691���698 DOI 10.1007/s00775-007-0219-9

A copper protein and a cytochrome bind at the same site on bacterial cytochrome c peroxidase

Biochemistry, 2004, 43 (46), pp 14566���14576 DOI: 10.1021/bi0485833

Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome C release in isolated mitochondria

Biochemistry, 2003, 42 (10), pp 3070���3080 DOI: 10.1021/bi026979d

A further investigation of the cytochrome b5���cytochrome c complex

J Biol Inorg Chem (2003) 8: 777���786 DOI 10.1007/s00775-003-0479-y

The isolation and characterization of cytochrome c nitrite reductase subunits (NrfA and NrfH) from Desulfovibrio desulfuricans ATCC 27774

Eur. J. Biochem. 270, 3904���3915 (2003) doi:10.1046/j.1432-1033.2003.03772.x

Produ����o de part��culas semelhantes a retrov��rus como candidatas a vacina para a Hepatite C

Disserta����o para obten����o do Grau de Mestre em Gen��tica Molecular e Biomedicina

O Santu��rio de Santa B��rbara de Padr��es ��� uma Perspectiva Religiosa e Art��stica na Lusit��nia dos S��culos I a III d. C.

Disserta����o apresentada para cumprimento dos requisitos necess��rios �� obten����o do grau de Mestre em Hist��ria da Arte ��� ��rea de especializa����o em Hist��ria da Arte da Antiguidade

C-reactive protein in early risk assessment in acute pancreatitis

ABSTRACT:C-reactive protein (CRP) has been widely used in the early risk assessment of patients with acute pancreatitis (AP), but unclear aspects about its prognostic accuracy in this setting persist. This project evaluated first CRP prognostic accuracy for severity, pancreatic necrosis (PNec), and in-hospital mortality (IM) in AP in terms of the best timing for CRP measurement and the optimal CRP cutoff points. Secondly it was evaluated the CRP measured at approximately 24 hours after hospital admission (CRP24) prognostic accuracy for IM in AP individually and in a combined model with a recent developed tool for the early risk assessment of patients with AP, the Bedside Index for Severity in AP (BISAP). Two single-centre retrospective cohort studies were held. The first study included 379 patients and the second study included 134 patients. Statistical methods such as the Hosmer-Lemeshow goodness-of-fit test, the area under the receiver-operating characteristic curve, the net reclassification improvement, and the integrated discrimination improvement were used. It was found that CRP measured at approximately 48 hours after hospital admission (CRP48) had a prognostic accuracy for severity, PNec, and IM in AP better than CRP measured at any other timing. It was observed that the optimal CRP48 cutoff points for severity, PNec, and IM in AP varied from 170mg/l to 190mg/l, values greater than the one most often recommended in the literature ��� 150mg/l. It was found that CRP24 had a good prognostic accuracy for IM in AP and that the cutoff point of 60mg/l had a negative predictive value of 100%. Finally it was observed that the prognostic accuracy of a combined model including BISAP and CRP24 for IM in AP could perform better than the BISAP alone model. These results might have a direct impact on the early risk assessment of patients with AP in the daily clinical practice.--------- RESUMO: A proteina c-reactiva (CRP) tem sido largamente usada na avalia����o precoce do risco em doentes com pancreatite aguda (AP), mas aspectos duvidosos acerca do seu valor progn��stico neste contexto persistem. Este projecto avaliou primeiro o valor progn��stico da CRP para a gravidade, a necrose pancre��tica (PNec) e a mortalidade intra-hospitalar (IM) na AP em termos do melhor momento para efectuar a sua medi����o e dos seus pontos-de-corte ��ptimos. Em segundo lugar foi avaliado o valor progn��stico da prote��na c-reactiva medida aproximadamente ��s 24 horas ap��s a admiss��o hospitalar (CRP24) para a IM na AP isoladamente e num modelo combinado, que incluiu uma ferramenta de avalia����o precoce do risco em doentes com AP recentemente desenvolvida, o Bedside Index for Severity in Acute Pancreatitis (BISAP). Dois estudos unic��ntricos de coorte retrospectivo foram realizados. O primeiro estudo incluiu 379 doentes e o segundo estudo incluiu 134 doentes. Metodologias estat��sticas como o teste de Hosmer-Lemeshow goodness-of-fit, a area under the receiver-operating characteristic curve, o net reclassification improvement e o integrated discrimination improvement foram usadas. Verificou-se que a CRP medida ��s 48 horas ap��s a admiss��o hospitalar (CRP48) teve um valor progn��stico para a gravidade, a PNec e a IM na AP melhor do que a CRP medida em qualquer outro momento. Observou-se que os pontos de corte ��ptimos da CRP48 para a gravidade, a PNec e a IM na AP variaram entre 170mg/l e 190mg/l, valores acima do valor mais frequentemente recomendado na literatura ��� 150mg/l. Verificou-se que a CRP medida aproximadamente ��s 24 horas ap��s a admiss��o hospitalar (CRP24) teve um bom valor progn��stico para a IM na AP e que o ponto de corte 60mg/l teve um valor preditivo negativo de 100%. Finalmente observou-se que o valor progn��stico de um modelo combinado incluindo o BISAP e a CRP24 para a IM na AP pode ter um desempenho melhor do que o do BISAP isoladamente. Estes resultados podem ter um impacto directo na avalia����o precoce do risco em doentes com AP na pr��tica cl��nica di��ria.

As dominicanas de Aveiro (c. 1450-1525): Mem��ria e identidade de uma comunidade textual

Tese apresentada para cumprimento dos requisitos necess��rios �� obten����o do grau de Doutor em Hist��ria, na especialidade de Hist��ria Medieval

Entre a Ilha e a Terra. Processos de constru����o do continente fronteiro �� Ilha de Mo��ambique (1763 - c. 1802)

Disserta����o apresentada para cumprimento dos requisitos necess��rios �� obten����o do grau de Mestre em Historia Moderna e dos Descobrimentos