Exploring nature profits: development of novel and potent lipophilic antioxidants based on galloylecinnamic hybrids

Phenolic acids are ubiquitous antioxidants accounting for approximately one third of the phenolic compounds in our diet. Their importance was supported by epidemiological studies that suggest an inverse relationship between dietary intake of phenolic antioxidants and the occurrence of diseases, such as cancer and neurodegenerative disorders. However, until now, most of natural antioxidants have limited therapeutic success a fact that could be related with their limited distribution throughout the body and with the inherent difficulties to attain the target sites. The development of phenolic antioxidants based on a hybrid concept and structurally based on natural hydroxybenzoic (gallic acid) and hydroxycinnamic (caffeic acid) scaffolds seems to be a suitable solution to surpass the mentioned drawbacks. Galloylecinnamic hybrids were synthesized and their antioxidant activity as well as partition coefficients and redox potentials evaluated. The structureepropertyeactivity relationship (SPAR) study revealed the existence of a correlation between the redox potentials and antioxidant activity. The galloylecinnamic acid hybrid stands out as the best antioxidant supplementing the effect of a blend of gallic acid plus caffeic acid endorsing the hypothesis that the whole is greater than the sum of the parts. In addition, some hybrid compounds possess an appropriate lipophilicity allowing their application as chain-breaking antioxidant in biomembranes or other type of lipidic systems. Their predicted ADME properties are also in accordance with the general requirements for drug-like compounds. Accordingly, these phenolic hybrids can be seen as potential antioxidants for tackling the oxidative status linked to the neurodegenerative, inflammatory or cancer processes.

Plano de negócios para empresa de iluminação de emergência

Dissertação de Mestrado em Finanças Empresariais

O Combate à fraude e evasão fiscais: a atuação da administração tributária e a avaliação dos resultados obtidos

Dissertação para obtenção do Grau de Mestre em Auditoria Orientação científica do Professor Coordenador Rodrigo Mário Oliveira Carvalho

A relação terapeuta-cliente: na perspectiva do cliente

O presente estudo resulta de uma crescente preocupação e percepção da importância da relação terapeuta-cliente e procura compreender a perspectiva do cliente e a forma como este sente e vive essa relação ao longo de todo o seu processo terapêutico. O estudo realizado, de natureza qualitativa e de carácter exploratório, visa sobretudo analisar a influência da relação terapeuta-cliente na perspectiva do cliente, identificar e descrever os fatores que a influenciam e perceber a mais-valia desta relação ao longo do processo terapêutico. Para tal, foram entrevistadas dezanove pessoas que estão a receber tratamento de terapia ocupacional. Para a recolha dos dados foi aplicada a entrevista semi-estruturada por se pretender um contributo mais envolvente, particularizado e subjetivo dos clientes. Através da realização do estudo e de acordo com a perspetiva dos clientes entrevistados, concluiu-se que a capacidade do terapeuta em construir e estabelecer um vínculo com o cliente ditará grande parte do sucesso ou insucesso do processo terapêutico. Porém, tão importante como formar e estabelecer um vínculo terapeuta-cliente é preciso ter a preocupação contínua de o manter sempre vivo e fortalecido. Para que tal aconteça, o terapeuta não pode menosprezar a experiência de vida e expectativas do cliente e deve assumir um papel de permanente preocupação e atenção a todas as transformações quotidianas pois estas influenciam o envolvimento do cliente nas suas atividades/ocupações e afetam a sua saúde e desempenho. O novo milénio requer dos profissionais de saúde em geral e dos terapeutas ocupacionais em particular, novas habilidades e competências. É fundamental adquirir a consciência de que os clientes são o centro de todo o processo terapêutico. É necessário ter uma visão holística e não fragmentada do cliente. É importante interagir com os clientes e permitir uma troca de conhecimento, entre o saber do cliente e o saber do terapeuta. Essa troca gera convergências, fortalece laços e o processo terapêutico avança. Nesse relacionamento, ambos aprendem, progridem e crescem.

A realidade virtual como factor de atracção para a engenharia

O objectivo da Realidade Virtual é simples de entender mas muito difícil de implementar: criar ambientes completamente indiferenciáveis do mundo real com os quais se possa interagir de um modo natural. Desde a criação do Sensorama por Morton Heiling em 1962, passando pela difusão do conceito pelo público geral na década de 90 até os dias de hoje, a evolução da Realidade Virtual tem sido constante. Este conjunto de tecnologias tem estado envolvido por uma certa descrença por parte da sociedade, motivada pelas grandes expectativas que lhe foram atribuídas e pelo estado de desenvolvimento do hardware aquando do seu auge. No entanto, actualmente assiste-se a um ressurgimento do seu interesse no público geral com a introdução de imagem estereoscópica no cinema ou o sucesso dos controladores da consola Nintendo Wii. Hoje em dia as suas aplicações são muito variadas: desde o treino de pilotos de avião ao tratamento de fobias, passando pela industria do entretenimento e a visita virtual de locais com interesse histórico ou turístico. O objectivo desta tese de mestrado é explorar uma área que ainda não tem sido muito abrangida pela Realidade Virtual e que cobre também aspectos educacionais e lúdicos de modo a ser um factor de atracção para os estudantes do ensino secundário: a simulação de instrumentos musicais. Para tal foi implementado um sistema capaz de simular instrumentos musicais de percussão (uma bateria) utilizando imagem estereoscópica, som posicional e interfaces com o utilizador realistas. Os resultados obtidos nas sessões de avaliação efectuadas por alunos recentemente ingressados no ensino superior demonstram que o sistema desenvolvido, bem como a inovação em interfaces do utilizador com os dispositivos electrónicos de uma forma geral, constituem um meio efectivo na sua motivação para a escolha de um curso na área da engenharia.

The economics of language or how can language be an asset? General reflections on the European case and brief focus on the case of portuguese

In this paper, we will focus on the importance of languages as an asset to people and companies in knowledge-based society, giving special attention to the case of portuguese, not forgetting the role of Higher Education Institutions in preparing students to be part of the new creative multilingual and sucsessful class.

The periodic table: contest and exhibition

The systemization and organization of ideas and concepts is an integral part of science. In chemistry, the organization of the periodic table of the chemical elements in the 1860s was one of the greatest scientific breakthroughs ever made and in fact during the 20th century it became a universally recognized scientific icon (1). The periodic table is the fundamental classificatory scheme of the elements and summarizes the realm of chemistry (2). Simply knowing the position of an element in the periodic table tells us about its properties and is usually enough to predict how the element will behave in a wide variety of different situations or reactions (1). Based on this potential mine of information, it is possible to make reliable predictions of the properties of the compounds that each element forms. Nowadays, the concept of the periodic table is starting to interact with other sciences and reports of periodic tables of amino acids (3), genetic codes (4), protein structures (5), and biology (6) can be found in the specialized literature. Symbiosis between science and art, for example, “The Periodic Table of The Elephants” (7), can also be seen. To appeal to a better understanding of the periodic table, the Instituto Superior de Engenharia do Instituto Politécnico do Porto and the Centro de Química da Universidade do Porto promoted a contest and exhibit with the goal of stimulating a wide and heterogeneous audience, ranging from young children and their parents to graduate students from several disciplines, to explore the nature of this icon. Imaginative educational activities such as contests (8–10), games (11, 12), and puzzles (13–15) provided a way to communicate with the general public with the goal of attracting students to science. This also constituted an interesting, informative, and entertaining alternative to non-interactive lectures. Simultaneously, artistic creativity was combined with scientific knowledge.

O Sistema uniforme de contas para a indústria hoteleira

Dissertação de Mestrado apresentado ao Instituto de Contabilidade e Administração do Porto para a obtenção do grau de Mestre em Contabilidade e Finanças, sob orientação de Professor Doutor Filipe Ambrósio e co-orientação do Mestre António Melo

Effects of international diffusion of a general purpose technology on wage inequality

This paper studies the effects of the diffusion of a General Purpose Technology (GPT) that spreads first within the developed North country of its origin, and then to a developing South country. In the developed general equilibrium growth model, each final good can be produced by one of two technologies. Each technology is characterized by a specific labor complemented by a specific set of intermediate goods, which are enhanced periodically by Schumpeterian R&D activities. When quality reaches a threshold level, a GPT arises in one of the technologies and spreads first to the other technology within the North. Then, it propagates to the South, following a similar sequence. Since diffusion is not even, neither intra- nor inter-country, the GPT produces successive changes in the direction of technological knowledge and in inter- and intra-country wage inequality. Through this mechanism the different observed paths of wage inequality can be accommodated.

A general overview on hybrid and electric vehicles

The economical and environment impacts of fossil energies increased the interest for hybrid, battery and fuel-cell electric vehicles. Several demanding engineering challenges must be faced, motivated by different physical domains integration. This paper aims to present an overview on hybrid (HEV) and electric vehicles (EV) basic structures and features. In addition, it will try to point out some of the most relevant challenges to overcome for HEV and EV may be a solid option for the mobility issue. New developments in energy storage devices and energy management systems (EMS) are crucial to achieve this goal.

POSIX trace based behavioural reflection

Traditional Real-Time Operating Systems (RTOS) are not designed to accommodate application specific requirements. They address a general case and the application must co-exist with any limitations imposed by such design. For modern real-time applications this limits the quality of services offered to the end-user. Research in this field has shown that it is possible to develop dynamic systems where adaptation is the key for success. However, adaptation requires full knowledge of the system state. To overcome this we propose a framework to gather data, and interact with the operating system, extending the traditional POSIX trace model with a partial reflective model. Such combination still preserves the trace mechanism semantics while creating a powerful platform to develop new dynamic systems, with little impact in the system and avoiding complex changes in the kernel source code.

Reconfigurable weblabs based on the IEEE1451 Std

Technology plays a double role in Education: it can act as a facilitator in the teaching/learning process and it can be the very subject of that process in Science & Engineering courses. This is especially true when students perform laboratory activities where they interact with equipment and objects under experimentation. In this context, technology can also play a facilitator role if it allows students to perform experiments in a remote fashion, through the Internet, in a so-called weblab or remote laboratory. No doubt, the Internet has been revolutionizing the educational process in many aspects, and it can be stated that remote laboratories are just an angle of that on-going revolution. As any other educational tool or resource, the i) pedagogical approach and the ii) technology used in the development of a remote laboratory can dictate its general success or its ephemeral existence. By pedagogical approach we consider the way remote experiments address the process by which students acquire experimental skills and link experimental results to theoretical concepts. In respect to technology, we discuss different specification and implementation alternatives, to show the case where the adoption of a family of standards would positively contribute to a larger acceptance and utilization of remote laboratories, and also to a wider collaboration in their development.

Implementação da filosofia Lean na gestão dos serviços de saúde: o caso português

Dissertação apresentada ao Instituto Politécnico do Porto para obtenção do Grau de Mestre em Gestão das Organizações, Ramo de Gestão de Empresas. Orientada por Prof. Dra. Maria Rosário Moreira e Prof. Dr. Paulo Sousa

Influência dos parâmetros geotécnicos na qualidade do desmonte de maciços rochosos fracturados

Uma das operações envolvidas no desmonte de maciços rochosos é a perfuração. A forma como esta é executada é determinante para o sucesso do desmonte. Quando realizada correctamente o desmonte produz uma boa fragmentação, reduzindo a sobrescavação. Assim, a correcta escolha das ferramentas de perfuração assume um papel preponderante para os custos do desmonte em maciço rochosos. Esta dissertação irá centrar-se nos parâmetros Geológicos, Geotécnicos e Geomecânicos e nos desvios de perfuração. O objectivo geral deste trabalho é perceber a interdependência dos parâmetros geológicogeotécnicos e geomecânicos do maciço rochoso com os desvios de perfuração, bem como estudar os ângulos de intersecção entre os furos e as descontinuidades que originam o desvio. O estudo dos parâmetros do maciço rochoso aliado a uma perfuração alinhada é salientado com o intuito de uma abordagem de geoengenharia integrada dos maciços rochosos.

Evaluating the quality and the success of online courses

Measuring the quality of a b-learning environment is critical to determine the success of a b-learning course. There are a lot of materials related to the quality process, namely different approaches and perspectives but none of them is specific of the product of a b-learning context. In this paper we identify the indicators that should be analyzed in order to determine the quality of a b-learning course, since its success reflect not only the student’s perception, but also what should be taken into account. B-Learning environments are relatively new and combine educational characteristics with technological elements that support the learning process and the training delivery. Our main objective is to know what a high quality b-learning environment is in students’’ perception and what are the main quality dimensions of these courses, in the perspective of the products and services offered. After a literature review concerning the quality process and in particular the b-learning quality field, a structure that provides the main elements that should be evaluated by students when we are measuring the quality and the success of b-learning product/services was created. The structure obtained was applied to a case study of the Polytechnic Institute of Oporto. Results presented will help institutions to deliver services with more quality and improve their long-term competitiveness.