36 resultados para ATROPHY INVOLVE
em Instituto Politécnico do Porto, Portugal
Resumo:
This paper will focus on some aspects of translation based on blending distinct linguistic domains such as English Language and Portuguese in using false friends in the English class in tertiary level students, reflecting namely on: 1. the choice of a word suitable to the context in L2 ; 2. the difficulties encountered by choice of that word that could be misleading, by relying in a false L1 reality that is going to adulterate reality in the L2 domain; 3. the difficulty in making such type of distinctions due to the lack of linguistic and lexical knowledge. 4. the need to study the cause of these difficulties by working, not only with their peers, but also with their language teacher to develop strategies to diminish and if possible to eradicate this type of linguistic and, above all, translation problem by making an inventory of those types of mistakes. In relation to the first point it is necessary to know that translation tasks involve much more than literal concepts ( Ladmiral, 1975) : furthermore it is necessary and suitable to realise that lexicon relies in significant contexts (Coseriu 1966), which connects both domains, that, at first sight do not seem to be compatible. In other words, although students have the impression they dominate lexicon due to the fact that they possess at least seven years of foreign language exposure that doesn’t mean they master the particularities engaged in such a delicate task as translation is concerned. There are some chromaticisms in the words (false friends), that need to be researched and analysed later on by both students and language teachers. The reason for such state of affairs lies in their academic formation, of a mainly general stream, which has enabled them only for knowledge of the foreign language, but not for the translation as a tool as it is required only when they reach the tertiary level. Besides, for their translations they rely, most of the times, on glossaries, whose dominant language is portuguese of Brazil, which is, obviously, much different from the portuguese mother tongue reality and even more of English. So it seems necessary to use with caution the working tools (glossaries) that work as surpluses, but could bring translation problems as we will see.
Resumo:
Este estudo refere-se a uma paciente de 33 anos com paralisia do nervo toráxico longo direito e consequente atrofia do grande dentado A paciente foi acompanhada durante 7 meses no serviço de Fisioterapia e tratada segundo as guidelines para o tratamento desta patologia. Após estabilização de resultados, por não apresentar mais melhoria, foi sujeita a análise electromigráfica no sentido de perceber quais as estratégias utilizadas pela paciente para compensar o défice do grande dentado, na manutenção de 4 movimentos: Elevação anterior a 90º, elevação lateral a 90º, elevação lateral no plano da omoplata a 90º e no push-up contra a parede. Foram avaliados o trapézio superior, médio e inferior, bem como o grande dentado. Verificou-se que não existe um padrão de activação consistente dos estabilizadores da omoplata em cadeia cinética aberta, sendo que o padrão é mantido em cadeia cinética fechada.
Resumo:
Na presente dissertação pretendemos averiguar da pertinência prática do actual modelo de protecção de dados clínicos, ou seja, se nele está devidamente consagrada a autonomia e a individualidade do utente; pretendemos ainda perceber a tendência evolutiva do sistema português de protecção de dados clínicos, nomeadamente a sua capacidade de inovação e adaptação aos sistemas internacionais, respeitando o nosso ordenamento jurídico. Concretamente, pretendemos perceber de que forma esta informação estará protegida, bem como até onde os utentes estarão consciencializados dos perigos que enfrentam. Embora este seja um problema mundial, o facto é que a Gestão do Sistema de Protecção de Dados Pessoais e Clínicos suscita polémica e interpretações diferentes, dada a sensibilidade ética do tema, a integridade humana. Além deste facto, estamos perante uma problemática que irá sempre envolver vários interesses e consequentemente um confronto de posições. Este trabalho procura ilustrar de que forma se lida com a gestão de dados pessoais no nosso país, de que modo se harmonizam os diferentes interesses e perspectivas, que prioridades se encontram na orientação governamental nesta matéria, quais as penalizações para os eventuais incumpridores e qual o futuro possível dos dados pessoais em saúde, tendo como objectivo comum uma eficácia e sustentabilidade dos mecanismos utilizados. Vamos encontrar interesses divergentes, compromissos permissivos ou restritivos de tratamento de dados, tendências que suportam interesses privados e públicos que se vão concretizar em escolhas eficientes de gestão de dados. Esta diversidade de comportamentos vai ser objecto de estudo e análise neste trabalho, procurando aferir das vantagens e desvantagens de um sistema de informação em saúde: universal com a população coberta, e integrado a fim de compartilhar informações de todos os pacientes, de todas as unidades de prestação de cuidados de saúde.
Resumo:
Dissertação de Mestrado submetida ao Instituto Superior de Contabilidade e Administração do Porto para a obtenção do grau de Mestre em Auditoria Trabalho efetuado sob a orientação do Mestre Carlos Martins
Resumo:
Introduction / Aims: Adopting the important decisions represents a specific task of the manager. An efficient manager takes these decisions during a sistematic process with well-defined elements, each with a precise order. In the pharmaceutical practice and business, in the supply process of the pharmacies, there are situations when the medicine distributors offer a certain discount, but require payment in a shorter period of time. In these cases, the analysis of the offer can be made with the help of the decision tree method, which permits identifying the decision offering the best possible result in a given situation. The aims of the research have been the analysis of the product offers of many different suppliers and the establishing of the most advantageous ways of pharmacy supplying. Material / Methods: There have been studied the general product offers of the following medical stores: A&G Med, Farmanord, Farmexim, Mediplus, Montero and Relad. In the case of medicine offers including a discount, the decision tree method has been applied in order to select the most advantageous offers. The Decision Tree is a management method used in taking the right decisions and it is generally used when one needs to evaluate the decisions that involve a series of stages. The tree diagram is used in order to look for the most efficient means to attain a specific goal. The decision trees are the most probabilistic methods, useful when adopting risk taking decisions. Results: The results of the analysis on the tree diagrams have indicated the fact that purchasing medicines with discount (1%, 10%, 15%) and payment in a shorter time interval (120 days) is more profitable than purchasing without a discount and payment in a longer time interval (160 days). Discussion / Conclusion: Depending on the results of the tree diagram analysis, the pharmacies would purchase from the selected suppliers. The research has shown that the decision tree method represents a valuable work instrument in choosing the best ways for supplying pharmacies and it is very useful to the specialists from the pharmaceutical field, pharmaceutical management, to medicine suppliers, pharmacy practitioners from the community pharmacies and especially to pharmacy managers, chief – pharmacists.
Resumo:
As the time goes on, it is a question of common sense to involve in the process of decision making people scattered around the globe. Groups are created in a formal or informal way, exchange ideas or engage in a process of argumentation and counterargumentation, negotiate, cooperate, collaborate or even discuss techniques and/or methodologies for problem solving. In this work it is proposed an agent-based architecture to support a ubiquitous group decision support system, i.e. based on the concept of agent, which is able to exhibit intelligent, and emotional-aware behaviour, and support argumentation, through interaction with individual persons or groups. It is enforced the paradigm of Mixed Initiative Systems, so the initiative is to be pushed by human users and/or intelligent agents.
Resumo:
Mestrado em Engenharia Electrotécnica e de Computadores
Resumo:
Ao longo dos últimos anos, as regras de associação têm assumido um papel relevante na extracção de informação e de conhecimento em base de dados e vêm com isso auxiliar o processo de tomada de decisão. A maioria dos trabalhos de investigação desenvolvidos sobre regras de associação têm por base o modelo de suporte e confiança. Este modelo permite obter regras de associação que envolvem particularmente conjuntos de itens frequentes. Contudo, nos últimos anos, tem-se explorado conjuntos de itens que surgem com menor frequência, designados de regras de associação raras ou infrequentes. Muitas das regras com base nestes itens têm particular interesse para o utilizador. Actualmente a investigação sobre regras de associação procuram incidir na geração do maior número possível de regras com interesse aglomerando itens raros e frequentes. Assim, este estudo foca, inicialmente, uma pesquisa sobre os principais algoritmos de data mining que abordam as regras de associação. A finalidade deste trabalho é examinar as técnicas e algoritmos de extracção de regras de associação já existentes, verificar as principais vantagens e desvantagens dos algoritmos na extracção de regras de associação e, por fim, desenvolver um algoritmo cujo objectivo é gerar regras de associação que envolvem itens raros e frequentes.
Resumo:
A adenosina é um nucleósido ubíquo envolvido na regulação de controlo do tónus vascular do tecido cavernoso, desempenhando um papel importante na fisiopatologia da Disfunção Erétil (DE) resistente aos fármacos relaxantes musculares clássicos. Apesar da importância comprovada dos recetores da adenosina na fisiopatologia da DE no homem, pouca informação é conhecida no que diz respeito à expressão e localização dos recetores purinérgicos no Tecido Cavernoso de Ratazana (TCR). Neste trabalho avaliou-se o fenótipo dos recetores purinérgicos responsáveis pela regulação do tónus do tecido erétil de ratazana por imunofluorescência indireta aplicada à microscopia confocal em co-culturas de células endoteliais e musculares lisas do TCR. Para além da caracterização imunofenotípica, desenvolveu-se uma técnica que permite diferenciar funcionalmente em tempo real (por microscopia confocal funcional) células musculares lisas e células endoteliais isoladas de TCR em co-cultura marcadas com a sonda fluorescente Fluo-4NW. Esta técnica permite distinguir cada um dos subtipos celulares mediante o padrão e a magnitude das oscilações dos níveis intracelulares de Ca2+ ([Ca2+]i) em resposta ao ATP (agonista P2) e à fenilefrina (PE, agonista α-adrenérgico). Nas células musculares lisas, observou-se uma resposta mais acentuada ao agonista α-adrenérgico, PE, e uma resposta menos significativa ao ATP. O contrário foi observado relativamente às células endoteliais. A incubação das células musculares lisas e endoteliais com ATP (300 μM) causou um aumento dos níveis de [Ca2+]i. O efeito do ATP (300 μM) parece envolver a ativação de recetores dos subtipos P2X1 e P2X3 sensíveis ao bloqueio com NF023 (3μM) e A317491 (100 nM), respetivamente. Já o aumento dos níveis [Ca2+]i produzido pelo ADP (300 μM) parece envolver a ativação de recetores P2Y1, P2Y12 e P2Y13 mediante o antagonismo produzido pelos antagonistas MRS 2179 (0,3μM), AR-C66096 (0,1 μM) e MRS 2211 (10μM), respetivamente. Os dois tipos celulares expressam imunorreatividade contra recetores A2A, A2B, P2X1, P2X3, P2Y1, P2Y12 e P2Y13.
Resumo:
Background: Chronic musculoskeletal pain involves connective tissue remodeling triggered by inflammatory mediators, such as bradykinin. Fibroblast cells signaling involve changes in intracellular Ca2+ ([Ca2+]i). ATP has been related to connective tissue mechanotransduction, remodeling and chronic inflammatory pain, via P2 purinoceptors activation. Here, we investigated the involvement of ATP in bradykinin-induced Ca2+ signals in human subcutaneous fibroblasts. Results: Bradykinin, via B2 receptors, caused an abrupt rise in [Ca2+]i to a peak that declined to a plateau, which concentration remained constant until washout. The plateau phase was absent in Ca2+-free medium; [Ca2+]i signal was substantially reduced after depleting intracellular Ca2+ stores with thapsigargin. Extracellular ATP inactivation with apyrase decreased the [Ca2+]i plateau. Human subcutaneous fibroblasts respond to bradykinin by releasing ATP via connexin and pannexin hemichannels, since blockade of connexins, with 2- octanol or carbenoxolone, and pannexin-1, with 10Panx, attenuated bradykinin-induced [Ca2+]i plateau, whereas inhibitors of vesicular exocytosis, such as brefeldin A and bafilomycin A1, were inactive. The kinetics of extracellular ATP catabolism favors ADP accumulation in human fibroblast cultures. Inhibition of ectonucleotidase activity and, thus, ADP formation from released ATP with POM-1 or by Mg2+ removal from media reduced bradykinin-induced [Ca2+]i plateau. Selective blockade of the ADP-sensitive P2Y12 receptor with AR-C66096 attenuated bradykinin [Ca2+]i plateau, whereas the P2Y1 and P2Y13 receptor antagonists, respectively MRS 2179 and MRS 2211, were inactive. Human fibroblasts exhibited immunoreactivity against connexin-43, pannexin-1 and P2Y12 receptor. Conclusions: Bradykinin induces ATP release from human subcutaneous fibroblasts via connexin and pannexin-1-containing hemichannels leading to [Ca2+]i mobilization through the cooperation of B2 and P2Y12 receptors.
Resumo:
Known algorithms capable of scheduling implicit-deadline sporadic tasks over identical processors at up to 100% utilisation invariably involve numerous preemptions and migrations. To the challenge of devising a scheduling scheme with as few preemptions and migrations as possible, for a given guaranteed utilisation bound, we respond with the algorithm NPS-F. It is configurable with a parameter, trading off guaranteed schedulable utilisation (up to 100%) vs preemptions. For any possible configuration, NPS-F introduces fewer preemptions than any other known algorithm matching its utilisation bound. A clustered variant of the algorithm, for systems made of multicore chips, eliminates (costly) off-chip task migrations, by dividing processors into disjoint clusters, formed by cores on the same chip (with the cluster size being a parameter). Clusters are independently scheduled (each, using non-clustered NPS-F). The utilisation bound is only moderately affected. We also formulate an important extension (applicable to both clustered and non-clustered NPS-F) which optimises the supply of processing time to executing tasks and makes it more granular. This reduces processing capacity requirements for schedulability without increasing preemptions.
Resumo:
Este estudo tem como objetivo determinar o papel que a certificação pela Norma Portuguesa 4427:2004 – “Sistemas de Gestão de Recursos Humanos – requisitos” (NP 4427:2004) assume no desenvolvimento das práticas de Gestão de Recursos Humanos. Neste sentido, foi realizada uma abordagem teórica à evolução temporal e conceptual da Gestão de Recursos Humanos e identificadas as melhores práticas que reconhecem nas pessoas um indispensável e estratégico ativo organizacional. Posteriormente é apresentada a NP 4427:2004 e o seu enquadramento no contexto organizacional português. Apresentando-se como uma temática moderna no âmbito da Gestão de Recursos Humanos, o presente estudo questiona se as empresas certificadas pela NP 4427:2004 promovem práticas de Recursos Humanos estratégicas, se o grau de intervenção destes Departamentos, no desenvolvimento das práticas, é maior nas empresas certificadas pela NP 4427:2004, e se os responsáveis destes setores possuem qualificação específica na área de Recursos Humanos. A um universo de 95 empresas foi aplicado um inquérito por questionário, que permitiu concluir que as organizações certificadas pela NP 4427:2004 promovem práticas de Recursos Humanos estratégicas e envolvem Departamentos de Recursos Humanos com elevado grau de intervenção no desenvolvimento das mesmas, sendo que os seus Responsáveis não possuem formação específica na área dos Recursos Humanos.
Resumo:
Joining of components with structural adhesives is currently one of the most widespread techniques for advanced structures (e.g., aerospace or aeronautical). Adhesive bonding does not involve drilling operations and it distributes the load over a larger area than mechanical joints. However, peak stresses tend to develop near the overlap edges because of differential straining of the adherends and load asymmetry. As a result, premature failures can be expected, especially for brittle adhesives. Moreover, bonded joints are very sensitive to the surface treatment of the material, service temperature, humidity and ageing. To surpass these limitations, the combination of adhesive bonding with spot-welding is a choice to be considered, adding a few advantages like superior static strength and stiffness, higher peeling and fatigue strength and easier fabrication, as fixtures during the adhesive curing are not needed. The experimental and numerical study presented here evaluates hybrid spot-welded/bonded single-lap joints in comparison with the purely spot-welded and bonded equivalents. A parametric study on the overlap length (LO) allowed achieving different strength advantages, up to 58% compared to spot-welded joints and 24% over bonded joints. The Finite Element Method (FEM) and Cohesive Zone Models (CZM) for damage growth were also tested in Abaqus® to evaluate this technique for strength prediction, showing accurate estimations for all kinds of joints.
Resumo:
Adhesive bonding as a joining or repair method has a wide application in many industries. Repairs with bonded patches are often carried out to re-establish the stiffness at critical regions or spots of corrosion and/or fatigue cracks. Single and double-strap repairs (SS and DS, respectively) are a viable option for repairing. For the SS repairs, a patch is adhesively-bonded on one of the structure faces. SS repairs are easy to execute, but the load eccentricity leads to peel peak stresses at the overlap edges. DS repairs involve the use of two patches, one on each face of the structure. These are more efficient than SS repairs, due to the doubling of the bonding area and suppression of the transverse deflection of the adherends. Shear stresses also become more uniform as a result of smaller differential straining. The experimental and Finite Element (FE) study presented here for strength prediction and design optimization of bonded repairs includes SS and DS solutions with different values of overlap length (LO). The examined values of LO include 10, 20 and 30 mm. The failure strengths of the SS and DS repairs were compared with FE results by using the Abaqus® FE software. A Cohesive Zone Model (CZM) with a triangular shape in pure tensile and shear modes, including the mixed-mode possibility for crack growth, was used to simulate fracture of the adhesive layer. A good agreement was found between the experiments and the FE simulations on the failure modes, elastic stiffness and strength of the repairs, showing the effectiveness and applicability of the proposed FE technique in predicting strength of bonded repairs. Furthermore, some optimization principles were proposed to repair structures with adhesively-bonded patches that will allow repair designers to effectively design bonded repairs.
Resumo:
The Maxwell equations, expressing the fundamental laws of electricity and magnetism, only involve the integer-order calculus. However, several effects present in electromagnetism, motivated recently an analysis under the fractional calculus (FC) perspective. In fact, this mathematical concept allows a deeper insight into many phenomena that classical models overlook. On the other hand, genetic algorithms (GA) are an important tool to solve optimization problems that occur in engineering. In this work we use FC and GA to implement the electrical potential of fractional order. The performance of the GA scheme and the convergence of the resulting approximations are analyzed.