Development of novel ionic liquids based on valproate anion

Valproic acid (2-propyl pentanoic acid) is a pharmaceutical drug used for treatment of epileptic seizures absence, tonic-clonic (grand mal), complex partial seizures, and mania in bipolar disorder [1]. Valproic acid is a slightly soluble in water and therefore as active pharmaceutical ingredient it is most commonly applied in form of sodium or magnesium valproate salt [1].However the list of adverse effects of these compounds is large and includes among others: tiredness, tremor, sedation and gastrointestinal disturbances [2]. Ionic liquids (ILs) are promising compounds as Active Pharmaceutical Ingredients (APIs)[3]. In this context, the combinations of the valproate anion with appropriate cation when ILs and salts are formed can significantly alter valproate physical, chemical and thermal properties.[4] This methodology can be used for drug modification (alteration of drug solubility in water, lipids, bioavailability, etc)[2] and therefore can eliminate some adverse effect of the drugs related to drug toxicity due for example to its solubility in water and lipids (interaction with intestines). Herein, we will discuss the development of ILs based on valproate anion (Figure 1) prepared according a recent optimized and sustainable acid-base neutralization method [4]. The organic cations such as cetylpyridinium, choline and imidazolium structures were selected based on their biocompatibility and recent applications in pharmacy [3]. All novel API-ILs based on valproate have been studied in terms of their physical, chemical (viscosity, density, solubility) and thermal (calorimetric studies) properties as well as their biological activity.

Computação em nuvem: avaliação do retorno do investimento: o caso do Ensino Superior Português

Em Portugal, as instituições de ensino superior dispõem de plataformas de e-learning que reflectem uma mais-valia para o processo de ensino-aprendizagem. No entanto, estas plataformas caracterizam-se por serem de âmbito privado expondo, desta forma, a tímida abertura das instituições na partilha do seu conhecimento, como também dos seus recursos. O paradigma Cloud Computing surge como uma solução, por exemplo, para a criação de uma federação de nuvens capaz de contemplar soluções heterogéneas, garantindo a interoperabilidade entre as plataformas das várias instituições de ensino, e promovendo os objectivos propostos pelo Processo de Bolonha, nomeadamente no que se refere à partilha de informação, de plataformas e serviços e promoção de projectos comuns. Neste âmbito, é necessário desenvolver ferramentas que permitam aos decisores ponderar as mais-valias deste novo paradigma. Assim, é conveniente quantificar o retorno esperado para o investimento, em recursos humanos e tecnológicos, exigido pelo modelo Cloud Computing. Este trabalho contribui para o estudo da avaliação do retorno do investimento (ROI) em infra-estruturas e serviços TIC (Tecnologias de Informação e Comunicação), resultante da análise de diferentes cenários relativos à introdução do paradigma Cloud Computing. Para tal, foi proposta uma metodologia de análise baseada num questionário, distribuído por diversas instituições de ensino superior portuguesas, contendo um conjunto de questões que permitiram identificar indicadores, e respectivas métricas, a usar na elaboração de modelos de estimação do ROI.

Construção de interfaces em Flex para sistemas de experimentação remota

Os laboratórios de experimentação remota estão normalmente associados a tecnologias ou soluções proprietárias, as quais restringem a sua utilização a determinadas plataformas e obrigam ao uso de software específico no lado do cliente. O ISEP possui um laboratório de experimentação remota, baseado em instrumentação virtual, usado no apoio ao ensino da electrónica e construído sobre uma plataforma NIELVIS da National Instruments. O software de controlo da plataforma recorre à linguagem gráfica de programação LabVIEW. Esta é uma ferramenta desenvolvida pela National Instruments que facilita o desenvolvimento de aplicações de sistemas de experimentação remota, mas que possui várias limitações, nomeadamente a necessidade de instalação do lado do cliente de um plug-in, cuja disponibilidade se encontra limitada a determinadas versões de sistemas operativos e de Web Browsers. A experiência anterior demonstrou que estas questões limitam o número de clientes com possibilidade de acesso ao laboratório remoto, para além de, em alguns casos, se ter verificado não ser transparente a sua instalação e utilização. Neste contexto, o trabalho de investigação consistiu no desenvolvimento de uma solução que permite a geração de interfaces que possibilitam o controlo remoto do sistema implementado, e que, ao mesmo tempo, são independentes da plataforma usada pelo cliente.

Traduzir palavras, aproximar culturas: o ensino da Interpretação de Acompanhamento no ISCAP

Numa sociedade onde as correntes migrações desenham um novo contexto de sociabilização e onde a globalização conduz ao aumento incomensurável das reuniões interculturais, é fulcral recentrar a importância do ensino da interpretação dita de comunidade. A inauguração do Mestrado em Tradução e Interpretação Especializadas, no ano lectivo de 2007/2008, no Instituto Superior de Contabilidade e Administração do Porto, reformulado a partir da Licenciatura Bi-Etápica homónima, veio apresentar um desenho dos curricula em Interpretação cujo entendimento é mais pragmático. Assim sendo, à tradicional divisão entre Interpretação Simultânea e Interpretação Consecutiva sucedeu a introdução das unidades curriculares de Interpretação de Conferência, Interpretação Remota e de Teleconferência e de Interpretação de Acompanhamento. Este estudo pretende apresentar e discutir as diferentes abordagens pedagógicas ensaiadas no decorrer da implementação da unidade curricular de Interpretação de Acompanhamento, sustentadas por uma reflexão de cariz científico-pedagógico, filtrada pelas tendências de investigação mais recentes nesta área. Adoptámos a designação de Interpretação de Acompanhamento para descrever uma situação comunicativa que decorre em contextos variados e heterogéneos, em detrimento de outras designações de abrangência mais restrita, como Interpretação de Liaison – que remete para um acompanhamento em contexto de negócios ou de visita cultural ou turística – e Interpretação de Comunidade – reportando-se à mediação linguística de alguém que não fala a linguagem da maioria, normalmente no âmbito judicial, social, ou de saúde. Concentraremos, por conseguinte, a nossa atenção nas questões que se seguem: Que estratégias pedagógicas melhor se adaptam ao ensino desta disciplina? Como reproduzir a heterogeneidade dos contextos comunicativos que a Interpretação de Acompanhamento envolve numa sala de aula? Que ponderação deve assumir o desempenho linguístico em comparação com as competências de mediação intercultural? Como integrar, na prática, conceitos e teorias no domínio da Interpretação de Acompanhamento?

Distribution system operation supported by contextual energy resource management based on intelligent SCADA

Future distribution systems will have to deal with an intensive penetration of distributed energy resources ensuring reliable and secure operation according to the smart grid paradigm. SCADA (Supervisory Control and Data Acquisition) is an essential infrastructure for this evolution. This paper proposes a new conceptual design of an intelligent SCADA with a decentralized, flexible, and intelligent approach, adaptive to the context (context awareness). This SCADA model is used to support the energy resource management undertaken by a distribution network operator (DNO). Resource management considers all the involved costs, power flows, and electricity prices, allowing the use of network reconfiguration and load curtailment. Locational Marginal Prices (LMP) are evaluated and used in specific situations to apply Demand Response (DR) programs on a global or a local basis. The paper includes a case study using a 114 bus distribution network and load demand based on real data.

A survey of techniques and technologies for web-based real-time interactive rendering

When exploring a virtual environment, realism depends mainly on two factors: realistic images and real-time feedback (motions, behaviour etc.). In this context, photo realism and physical validity of computer generated images required by emerging applications, such as advanced e-commerce, still impose major challenges in the area of rendering research whereas the complexity of lighting phenomena further requires powerful and predictable computing if time constraints must be attained. In this technical report we address the state-of-the-art on rendering, trying to put the focus on approaches, techniques and technologies that might enable real-time interactive web-based clientserver rendering systems. The focus is on the end-systems and not the networking technologies used to interconnect client(s) and server(s).

Constructing and Using Multimodal Narratives to Research in Science Education: Contributions Based on Practical Classroom

This study deals with the problem of how to collect genuine and useful data about science classroom practices, and preserving the complex and holistic nature of teaching and learning. Additionally, we were looking for an instrument that would allow comparability and verifiability for teaching and research purposes. Given the multimodality of teaching and learning processes, we developed the multimodal narrative (MN), which describes what happens during a task and incorporates data such as examples of students’ work.

Enabling inter-domain transactions in bridge-based hybrid wired/wireless PROFIBUS networks

The marriage of emerging information technologies with control technologies is a major driving force that, in the context of the factory-floor, is creating an enormous eagerness for extending the capabilities of currently available fieldbus networks to cover functionalities not considered up to a recent past. Providing wireless capabilities to such type of communication networks is a big share of that effort. The RFieldbus European project is just one example, where PROFIBUS was provided with suitable extensions for implementing hybrid wired/wireless communication systems. In RFieldbus, interoperability between wired and wireless components is achieved by the use specific intermediate networking systems operating as repeaters, thus creating a single logical ring (SLR) network. The main advantage of the SLR approach is that the effort for protocol extensions is not significant. However, a multiple logical ring (MLR) approach provides traffic and error isolation between different network segments. This concept was introduced in, where an approach for a bridge-based architecture was briefly outlined. This paper will focus on the details of the inter-Domain Protocol (IDP), which is responsible for handling transactions between different network domains (wired or wireless) running the PROFIBUS protocol.

Server-based scheduling of parallel real-time tasks

Multicore platforms have transformed parallelism into a main concern. Parallel programming models are being put forward to provide a better approach for application programmers to expose the opportunities for parallelism by pointing out potentially parallel regions within tasks, leaving the actual and dynamic scheduling of these regions onto processors to be performed at runtime, exploiting the maximum amount of parallelism. It is in this context that this paper proposes a scheduling approach that combines the constant-bandwidth server abstraction with a priority-aware work-stealing load balancing scheme which, while ensuring isolation among tasks, enables parallel tasks to be executed on more than one processor at a given time instant.

Relatório de estágio em Educação Pré-Escolar

Mestrado em Educação Pré-Escolar

Implementing multicore real-time scheduling algorithms based on task splitting using ada 2012

Multiprocessors, particularly in the form of multicores, are becoming standard building blocks for executing reliable software. But their use for applications with hard real-time requirements is non-trivial. Well-known realtime scheduling algorithms in the uniprocessor context (Rate-Monotonic [1] or Earliest-Deadline-First [1]) do not perform well on multiprocessors. For this reason the scientific community in the area of real-time systems has produced new algorithms specifically for multiprocessors. In the meanwhile, a proposal [2] exists for extending the Ada language with new basic constructs which can be used for implementing new algorithms for real-time scheduling; the family of task splitting algorithms is one of them which was emphasized in the proposal [2]. Consequently, assessing whether existing task splitting multiprocessor scheduling algorithms can be implemented with these constructs is paramount. In this paper we present a list of state-of-art task-splitting multiprocessor scheduling algorithms and, for each of them, we present detailed Ada code that uses the new constructs.

Relatório de estágio

Mestrado em Educação Pré-Escolar e Ensino do 1.º Ciclo do Ensino Básico

Engineering a search and rescue application with a wireless sensor network - based localization mechanism

The advent of Wireless Sensor Network (WSN) technologies is paving the way for a panoply of new ubiquitous computing applications, some of them with critical requirements. In the ART-WiSe framework, we are designing a two-tiered communication architecture for supporting real-time and reliable communications in WSNs. Within this context, we have been developing a test-bed application, for testing, validating and demonstrating our theoretical findings - a search&rescue/pursuit-evasion application. Basically, a WSN deployment is used to detect, localize and track a target robot and a station controls a rescuer/pursuer robot until it gets close enough to the target robot. This paper describes how this application was engineered, particularly focusing on the implementation of the localization mechanism.

An integrated reusable remote laboratory to complement electronics teaching

The great majority of the courses on science and technology areas where lab work is a fundamental part of the apprenticeship was not until recently available to be taught at distance. This reality is changing with the dissemination of remote laboratories. Supported by resources based on new information and communication technologies, it is now possible to remotely control a wide variety of real laboratories. However, most of them are designed specifically to this purpose, are inflexible and only on its functionality they resemble the real ones. In this paper, an alternative remote lab infrastructure devoted to the study of electronics is presented. Its main characteristics are, from a teacher's perspective, reusability and simplicity of use, and from a students' point of view, an exact replication of the real lab, enabling them to complement or finish at home the work started at class. The remote laboratory is integrated in the Learning Management System in use at the school, and therefore, may be combined with other web experiments and e-learning strategies, while safeguarding security access issues.

Reverse problem-based learning - a case study with a Braille machine

Engineering Education includes not only teaching theoretical fundamental concepts but also its verification during practical lessons in laboratories. The usual strategies to carry out this action are frequently based on Problem Based Learning, starting from a given state and proceeding forward to a target state. The possibility or the effectiveness of this procedure depends on previous states and if the present state was caused or resulted from earlier ones. This often happens in engineering education when the achieved results do not match the desired ones, e.g. when programming code is being developed or when the cause of the wrong behavior of an electronic circuit is being identified. It is thus important to also prepare students to proceed in the reverse way, i.e. given a start state generate the explanation or even the principles that underlie it. Later on, this sort of skills will be important. For instance, to a doctor making a patient?s story or to an engineer discovering the source of a malfunction. This learning methodology presents pedagogical advantages besides the enhanced preparation of students to their future work. The work presented on his document describes an automation project developed by a group of students in an engineering polytechnic school laboratory. The main objective was to improve the performance of a Braille machine. However, in a scenario of Reverse Problem-Based learning, students had first to discover and characterize the entire machine's function before being allowed (and being able) to propose a solution for the existing problem.