14 resultados para haemoglobin utilization
em Repositório Científico do Instituto Politécnico de Lisboa - Portugal
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The present work reports on the practical cooperation between two Universities from Hungary and Portugal. Students from Portugal are remotely accessing an experimental facility, which is physically in Hungary. The cooperation among these Higher Education establishments allowed the development and testing of a Remote Laboratory at the BME. This paper reports on the characteristics and initial testing of the Thermocouples Rise Time Measurement System and provides information on development and students' feedback.
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Introduction - Knowledge on the metabolic changes and nutritional needs during the postsurgical anabolic phase in infants is scarce. This analysis explores the associations of resting energy expenditure (REE) and macronutrient utilization with body composition of full-term infants, during catch-up growth after corrective surgery of major congenital anomalies. Methods - A cohort of full-term appropriate for-gestational-age neonates subjected to corrective surgery of major congenital anomalies were recruited after gaining weight for at least one week. REE and macronutrient utilization, measured by respiratory quotient (RQ), were assessed by indirect calorimetry using the Deltatrac II Metabolic Monitor ®. Body composition, expressed as fat-free mass (FFM), fat mass (FM) and adiposity defined as percentage of FM (% FM), was measured by air displacement plethysmography using the Pea Pod ®. Results - Four infants were included at 3 to 5 postnatal weeks. Recommended energy and macronutrient intakes for healthy term infants were provided. Through the study, the median (min-max) REE (Kcal/Kg FFM/d) was 70.8 (60.6-96.1) and RQ was 0.99 (0.72-1.20). Steady increases in both body weight and FFM were associated with initial decrease in FM and adiposity followed by their increase. Low RQ preceded decrease in adiposity. Conclusion - The marked adiposity depletion, not expected during steady weight gain in the postsurgical period, prompts us to report this finding. The subsequent adiposity catch-up was associated with relatively high REE and RQ, suggesting preferential oxidation of carbohydrates and preservation of lipids for fat storage.
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O presente documento enquadra-se no âmbito do trabalho final do mestrado (TFM) do curso de Engenharia Civil, na área de especialização de Hidráulica, do Instituto Superior de Engenharia de Lisboa, sob a forma de um projeto na fase de estudo prévio com o título ―Gestão Sustentável da Água no empreendimento turístico Parque de Campismo da Ilha do Pessegueiro situado em Porto Covo - Região de Turismo do Alentejo‖. Este trabalho é constituído essencialmente por 5 partes. Sendo a primeira uma breve introdução às questões a abordar, a segunda corresponde à discrição teórica do uso eficiente da água baseando-se no PNEUA (Programa nacional para o uso eficiente da água). Já a terceira parte é relativa ao atual sistema de utilização da água no Parque de campismo da ilha do pessegueiro (PCIP), sendo a quarta o estudo do desenvolvimento do projecto para a gestão eficiente da água no empreendimento e a quinta parte o estudo de viabilidade económica e financeira a implementar no projecto. Para além da implementação de medidas de poupança são também objetivos principais deste trabalho a reutilização da água através da recolha, o tratamento e armazenamento das águas residuais e aproveitamento das águas pluviais para posterior abastecimento do sistema de utilização em descargas sanitárias, lavagem de pavimentos e regas de espaços verdes. São, portanto, três os subsistemas de gestão eficiente da água que se pretende implementar. Dá-se importância ao estudo de viabilidade económica do projeto, cujo período de retorno do capital investido em capitais próprios e alheios é de seis anos. Este projeto pretende dar apoio técnico ao uso eficiente da água no PCIP, de forma a conseguir por um lado obter vantagens económicas e por outro proteger o ambiente. As vantagens económicas são interessantes para orientar os recursos financeiros para outros investimentos e as questões ambientais são a base de uma campanha, já em curso, para obtenção de certificação energética, em conjunto com outras práticas já em curso, nomeadamente a recolha seletiva de resíduos sólidos para recircular e aproveitamento de energia solar.
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Background: Poor nutritional status and worse health-related quality of life (QoL) have been reported in haemodialysis (HD) patients. The utilization of generic and disease specific QoL questionnaires in the same population may provide a better understanding of the significance of nutrition in QoL dimensions. Objective: To assess nutritional status by easy to use parameters and to evaluate the potential relationship with QoL measured by generic and disease specific questionnaires. Methods: Nutritional status was assessed by subjective global assessment adapted to renal patients (SGA), body mass index (BMI), nutritional intake and appetite. QoL was assessed by the generic EuroQoL and disease specific Kidney Disease Quality of Life-Short Form (KDQoL-SF) questionnaires. Results: The study comprised 130 patients of both genders, mean age 62.7 ± 14.7 years. The prevalence of undernutrition ranged from 3.1% by BMI ≤ 18.5 kg/m2 to 75.4% for patients below energy and protein intake recommendations. With the exception of BMI classification, undernourished patients had worse scores in nearly all QoL dimensions (EuroQoL and KDQoL-SF), a pattern which was dominantly maintained when adjusted for demographics and disease-related variables. Overweight/obese patients (BMI ≥ 25) also had worse scores in some QoL dimensions, but after adjustment the pattern was maintained only in the symptoms and problems dimension of KDQoL-SF (p = 0.011). Conclusion: Our study reveals that even in mildly undernourished HD patients, nutritional status has a significant impact in several QoL dimensions. The questionnaires used provided different, almost complementary perspectives, yet for daily practice EuroQoL is simpler. Assuring a good nutritional status, may positively influence QoL.
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Background: Protein-energy wasting (PEW), associated with inflammation and overhydration, is common in haemodialysis (HD) patients and is associated with high morbidity and mortality. Objective: Assess the relationship between nutritional status, markers of inflammation and body composition through bioimpedance spectroscopy (BIS) in HD patients. Methods: This observational, cross-sectional, single centre study, carried out in an HD centre in Forte da Casa (Portugal), involved 75 patients on an HD programme. In all participating patients, the following laboratory tests were conducted: haemoglobin, albumin, C-reactive protein (CRP) and 25-hydroxyvitamin D3 [25(OH)D3]. The body mass index of all patients was calculated and a modified version of subjective global assessment (SGA) was produced for patients on dialysis. Intracellular water (ICW) and extracellular water (ECW) were measured by BIS (Body Composition Monitor®, Fresenius Medical Care®) after the HD session. In statistical analysis, Spearman’s correlation was used for the univariate analysis and linear regression for the multivariate analysis (SPSS 14.0). A P value of <.05 was considered statistically significant. Results: PEW, inversely assessed through the ICW/body weight (BW) ratio, was positively related to age (P<.001), presence of diabetes (P=.004), BMI (P=.01) and CRP (P=.008) and negatively related to albumin (p=.006) and 25(OH)D3 (P=.007). Overhydration, assessed directly through the ECW/BW ratio, was positively related with CRP (P=.009) and SGA (P=.03), and negatively with 25(OH)D3 (P=.006) and BMI (P=.01). In multivariate analysis, PEW was associated with older age (P<.001), the presence of diabetes (P=.003), lower 25(OH)D3 (P=.008), higher CRP (P=.001) and lower albumin levels (P=.004). Over-hydration was associated with higher CRP (P=.001) and lower levels of 25(OH)D3 (P=.003). Conclusions: Taking these results into account, the ICW/BW and ECW/BW ratios, assessed with BIS, have proven to be good markers of the nutritional and inflammatory status of HD patients. BIS may be a useful tool for regularly assessing the nutritional and hydration status in these patients and may allow nutritional advice to be improved and adjusted.
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Projecto para obtenção do grau de Mestre em Engenharia Informática e de computadores
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Trabalho de Projecto para obtenção do grau de Mestre em Engenharia Civil na Área de Especialização de Estruturas
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Nanotechnology is an important emerging industry with a projected annual market of around one trillion dollars by 2015. It involves the control of atoms and molecules to create new materials with a variety of useful functions. Although there are advantages on the utilization of these nano-scale materials, questions related with its impact over the environment and human health must be addressed too, so that potential risks can be limited at early stages of development. At this time, occupational health risks associated with manufacturing and use of nanoparticles are not yet clearly understood. However, workers may be exposed to nanoparticles through inhalation at levels that can greatly exceed ambient concentrations. Current workplace exposure limits are based on particle mass, but this criteria could not be adequate in this case as nanoparticles are characterized by very large surface area, which has been pointed out as the distinctive characteristic that could even turn out an inert substance into another substance exhibiting very different interactions with biological fluids and cells. Therefore, it seems that, when assessing human exposure based on the mass concentration of particles, which is widely adopted for particles over 1 μm, would not work in this particular case. In fact, nanoparticles have far more surface area for the equivalent mass of larger particles, which increases the chance they may react with body tissues. Thus, it has been claimed that surface area should be used for nanoparticle exposure and dosing. As a result, assessing exposure based on the measurement of particle surface area is of increasing interest. It is well known that lung deposition is the most efficient way for airborne particles to enter the body and cause adverse health effects. If nanoparticles can deposit in the lung and remain there, have an active surface chemistry and interact with the body, then, there is potential for exposure. It was showed that surface area plays an important role in the toxicity of nanoparticles and this is the metric that best correlates with particle-induced adverse health effects. The potential for adverse health effects seems to be directly proportional to particle surface area. The objective of the study is to identify and validate methods and tools for measuring nanoparticles during production, manipulation and use of nanomaterials.
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Introdução – A ressonância magnética funcional (RMf) é hoje uma ferramenta fundamental na investigação funcional do cérebro humano, quer em indivíduos saudáveis quer em doentes com patologias diversas. É uma técnica complexa que necessita de uma aplicação cuidada e rigorosa e uma compreensão dos mecanismos biofísicos, de modo a serem obtidos resultados fiáveis e com melhor aceitação clínica. O efeito BOLD (Blood Oxygenation Level Dependent), que se baseia nas propriedades magnéticas da hemoglobina, é o método mais utilizado para medir a atividade cerebral por RMf. Objetivos – Otimizar um protocolo de RMf por efeito BOLD em voluntários saudáveis para mapeamento do córtex motor, de modo a que possa ser aplicado no futuro em doentes com patologias diversas. Metodologia – Foram estudados 34 voluntários saudáveis divididos em 2 grupos de estudo: BOLD 1 e BOLD 2. Com vista à otimização, foram testados no subgrupo BOLD 1 diferentes paradigmas e no subgrupo BOLD 2 foi estudada a influência do tempo de eco (TE). Para as várias condições foram comparados os volumes da região ativada e os níveis de ativação obtidos. Resultados/Discussão – O córtex motor foi identificado em todos os voluntários estudados. Não foram detetadas diferenças estatisticamente significativas quando comparados os resultados obtidos com os diferentes parâmetros de aquisição. Conclusão – O protocolo foi otimizado tendo em conta o nível de conforto reportado pelos voluntários. Uma vez que se pretende aplicar este mesmo protocolo no estudo de doentes, este fator torna-se particularmente relevante.
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Trabalho Final de Mestrado para obtenção do grau de Mestre em Engenharia Mecânica
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Relatório de estágio apresentado à Escola Superior de Comunicação Social como parte dos requisitos para obtenção de grau de mestre em Jornalismo.
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Trabalho Final de Mestrado para obtenção do grau de Mestre em Engenharia Química
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Cloud SLAs compensate customers with credits when average availability drops below certain levels. This is too inflexible because consumers lose non-measurable amounts of performance being only compensated later, in next charging cycles. We propose to schedule virtual machines (VMs), driven by range-based non-linear reductions of utility, different for classes of users and across different ranges of resource allocations: partial utility. This customer-defined metric, allows providers transferring resources between VMs in meaningful and economically efficient ways. We define a comprehensive cost model incorporating partial utility given by clients to a certain level of degradation, when VMs are allocated in overcommitted environments (Public, Private, Community Clouds). CloudSim was extended to support our scheduling model. Several simulation scenarios with synthetic and real workloads are presented, using datacenters with different dimensions regarding the number of servers and computational capacity. We show the partial utility-driven driven scheduling allows more VMs to be allocated. It brings benefits to providers, regarding revenue and resource utilization, allowing for more revenue per resource allocated and scaling well with the size of datacenters when comparing with an utility-oblivious redistribution of resources. Regarding clients, their workloads’ execution time is also improved, by incorporating an SLA-based redistribution of their VM’s computational power.
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In this paper an automatic classification algorithm is proposed for the diagnosis of the liver steatosis, also known as, fatty liver, from ultrasound images. The features, automatically extracted from the ultrasound images used by the classifier, are basically the ones used by the physicians in the diagnosis of the disease based on visual inspection of the ultrasound images. The main novelty of the method is the utilization of the speckle noise that corrupts the ultrasound images to compute textural features of the liver parenchyma relevant for the diagnosis. The algorithm uses the Bayesian framework to compute a noiseless image, containing anatomic and echogenic information of the liver and a second image containing only the speckle noise used to compute the textural features. The classification results, with the Bayes classifier using manually classified data as ground truth show that the automatic classifier reaches an accuracy of 95% and a 100% of sensitivity.