Amadeus, Papa e Greve no Natal

O direito constitucional à greve está consagrado no art. 57º da Constituição. Desde que estejam assegurados os serviços mínimos – indispensáveis às necessidades sociais impreteríveis -, o direito à greve é absolutamente inalienável e não pode ser coarctado por uma qualquer “requisição civil”, em conjugação com o art. 18º/2 da Constituição; The constitutional right to strike is enshrined in art. 57 of the Constitution. Provided they are guaranteed the minimum services - indispensable to essential social needs - the right to strike is absolutely inalienable and can not be inhibited by any "civil requisition", in conjunction with art. 18/2 of the Constitution.

1º DE MAIO e SISTEMA FISCAL

A segurança no emprego está consagrada no art. 53º da CRP: “É garantida aos trabalhadores a segurança no emprego, sendo proibidos os despedimentos sem justa causa ou por motivos políticos ou ideológicos”. É também a celebração dum ambiente de trabalho humano em que sejam consagrados os direitos e deveres fundamentais dos trabalhadores, como o direito e dever à saúde laboral e a uma jornada justa de horas de trabalho, o direito e o dever ao descanso, o direito e o dever a formar família, ter filhos e ter tempo para a mesma, o direito e o dever a fazer o próprio trabalho e executar as diferentes tarefas pelas quais está encarregue. § Job security is enshrined in art. 53 of CRP, "is guaranteed to security workers in employment, the redundancies being prohibited without just cause or for political or ideological reasons." It is also the celebration of a human working environment in which the fundamental rights and duties of workers are enshrined, as the right and duty to labor health and a fair day's working hours, the right and the duty to rest, the right and the duty to form families, have children and take time for it, the right and the duty to do the work itself and perform the different tasks for which it is responsible.

Mapping Culture and Compromised Art in the Era of Globalization

This work presents an analysis of the cultural and artistic field, positively compromised with social and political questions. The authors start with the categorization of the idea of culture and move to vindication art movements. These movements, which followed the first vanguards and worked from the compromise with “otherness”, are at the origin of the contemporary denomination of political art. In this context, the authors approach the origins of activist art, referring to issues of gender, multiculturalism, globalization, and poverty. The different forms of presenting content are also an object of analysis: from art tradition to the contamination of daily life, from local to global, from street contact to digital.

Targeting lactate transport suppresses in vivo breast tumour growth

Background: Most cancers, including breast cancer, have high rates of glucose consumption, associated with lactate production, a process referred as “Warburg effect”. Acidification of the tumour microenvironment by lactate extrusion, performed by lactate transporters (MCTs), is associated with higher cell proliferation, migration, invasion, angiogenesis and increased cell survival. Previously, we have described MCT1 up-regulation in breast carcinoma samples and demonstrated the importance of in vitro MCT inhibition. In this study, we performed siRNA knockdown of MCT1 and MCT4 in basal-like breast cancer cells in both normoxia and hypoxia conditions to validate the potential of lactate transport inhibition in breast cancer treatment. Results: The effect of MCT knockdown was evaluated on lactate efflux, proliferation, cell biomass, migration and invasion and induction of tumour xenografts in nude mice. MCT knockdown led to a decrease in in vitro tumour cell aggressiveness, with decreased lactate transport, cell proliferation, migration and invasion and, importantly, to an inhibition of in vivo tumour formation and growth. Conclusions: This work supports MCTs as promising targets in cancer therapy, demonstrates the contribution of MCTs to cancer cell aggressiveness and, more importantly, shows, for the first time, the disruption of in vivo breast tumour growth by targeting lactate transport.