2 resultados para Proverbs, Danish.
Resumo:
This paper will examine the various processes through which the folktale ‘On the Advantage of Silence’, first recorded by the Persian poet Sa’di in his The Gulistān (Rose Garden) (1258),has been altered in terms of content, style and function since the 13th century. Particular emphasis will be placed on the expression ‘tied stones and loose dogs’ which became its punch line in jest tales of the 17th and 18th centuries, and which was subsequently appropriated in the Irish language as a blason populaire denigrating the town of Ballyneety,Co. Limerick, and then as a legal expression in the Irish legal system in the 20th century.
Resumo:
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL)
cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a
lower risk of coronary heart disease (CHD). Mice that have depleted Scarb1 (SR-BI
knockout mice) have markedly elevated HDL-C levels but, paradoxically, increased
atherosclerosis. The impact of SR-BI on HDL metabolism and CHD risk in humans remains
unclear. Through targeted sequencing of coding regions of lipid-modifying genes in 328
individuals with extremely high plasma HDL-C levels, we identified a homozygote for a lossof-function
variant, in which leucine replaces proline 376 (P376L), in SCARB1, the gene
encoding SR-BI. The P376L variant impairs posttranslational processing of SR-BI and
abrogates selective HDL cholesterol uptake in transfected cells, in hepatocyte-like cells
derived from induced pluripotent stem cells from the homozygous subject, and in mice.
Large population-based studies revealed that subjects who are heterozygous carriers of
the P376L variant have significantly increased levels of plasma HDL-C. P376L carriers have
a profound HDL-related phenotype and an increased risk of CHD (odds ratio = 1.79, which is
statistically significant).
