Rhodopsin and the Others: A Historical Perspective on Structural Studies of G Protein-Coupled Receptors

The role of rhodopsin as a structural prototype for the study of the whole superfamily of G protein-coupled receptors (GPCRs) is reviewed in an historical perspective. Discovered at the end of the nineteenth century, fully sequenced since the early 1980s, and with direct three-dimensional information available since the 1990s, rhodopsin has served as a platform to gather indirect information on the structure of the other superfamily members. Recent breakthroughs have elicited the solution of the structures of additional receptors, namely the beta 1- and beta 2-adrenergic receptors and the A(2A) adenosine receptor, now providing an opportunity to gauge the accuracy of homology modeling and molecular docking techniques and to perfect the computational protocol. Notably, in coordination with the solution of the structure of the A(2A) adenosine receptor, the first "critical assessment of GPCR structural modeling and docking" has been organized, the results of which highlighted that the construction of accurate models, although challenging, is certainly achievable. The docking of the ligands and the scoring of the poses clearly emerged as the most difficult components. A further goal in the field is certainly to derive the structure of receptors in their signaling state, possibly in complex with agonists. These advances, coupled with the introduction of more sophisticated modeling algorithms and the increase in computer power, raise the expectation for a substantial boost of the robustness and accuracy of computer-aided drug discovery techniques in the coming years.

Architecture, memory and historical continuity in Old Cairo

The hawari (local communities) of Old Cairo resemble a unique societal context whose history is actively involved in the contemporary everyday production of local habits, traditions and social practice. By the virtue of its durability and ability to survive, Architecture brings events and traditions of the past alive into the present through the spatial transformation, social practice and the value of the historical-fabric. The presence of buildings and houses from different historical periods has helped the local community’s memory to carry social practices over from one generation to another. This article explores the relationship between architecture, memory and everyday social practices through determining the way architecture moderates community experiences and communicates narratives among generations in haret al-Darb al-Asfar in old Cairo. Architecture emerges as a moderator of cross-time communication and as physical elements that help visualize history, situate values and materialize local traditions in old Cairo. Architecture, as process and product this article reports, works as agent of continuity, which in conjunction with the narrators, brings the full experience of the past alive in the present and helps guide future generations.

Historical Theatre: The Task of the Translator

This article discusses ways in which the translator
may approach the plays of the Spanish Golden
Age in order to create translations free from the
philological deadness that characterises so many
versions to date. By thinking of translation both
as a writing practice that eschews locatedness,
and an ethical regime that is anxious to preserve
the rights of alterity, this article proposes a series
of translational strategies geared to the writing
of translations that give English-language
expression to these classical plays, while
simultaneously belonging to themselves

New Financial Elites, or Financial Dualism in Historical perspective? An Extended Reply to Folkman, Froud, Johal and Williams

This paper challenges the recent suggestion that a new financial elite has evolved which is able to capture substantial profit shares for itself. Specifically, it questions the assumption that new groups of financial intermediaries have increased in significance primarily because there is evidence that various types of financial speculators have played a similarly extensive role at several junctures of economic development. The paper then develops the alternative hypothesis that, rather than being a recent development, the rise of these financial intermediaries is a cyclical phenomenon which is linked to specific regimes of capital accumulation. The hypothesis is underpinned by historical data from the US National Income and Product Accounts for the period from 1930 to 2000, which suggest that the activities of `mainstream' financial intermediaries have been accompanied by the frequently countercyclical activities of a `speculative' sector of security and commodity brokers. Based on the combination of this qualitative and quantitative evidence, the paper concludes that the rise of a speculative financial sector is a potentially recurrent phenomenon which is linked to periods of economic restructuring and turmoil.