Ordering Quantiles through Confidence Statements

Ranking variables according to their relevance to predict an outcome is an important task in biomedicine. For instance, such ranking can be used for selecting a smaller number of genes to then apply other sophisticated experiments only on genes identified as important. A nonparametric method called Quor is designed to provide a confidence value for the order of arbitrary quantiles of different populations using independent samples. This confidence may provide insights about possible differences among groups and yields a ranking of importance for the variables. Computations are efficient and use exact distributions with no need for asymptotic considerations. Experiments with simulated data and with multiple real -omics data sets are performed and they show advantages and disadvantages of the method. Quor has no assumptions but independence of samples, thus it might be a better option when assumptions of other methods cannot be asserted. The software is publicly available on CRAN.

Use of physiotherapy and alternatives by children with cerebral palsy: a population study

Objectives: To describe the use of physiotherapy services and alternative therapies by a population of children with moderate to severe cerebral palsy (CP).
Design: Descriptive cross-sectional survey.
Subjects: A total of 212 parents of children aged 4–14 years with moderate to severe CP were identified from the Northern Ireland Cerebral Palsy Register (NICPR) and a random subsample of their paediatric physiotherapists.
Main measures: A standardized description of motor impairment or assessment form; a postal questionnaire to parents and paediatric physiotherapists (to validate parents’ reports of service use).
Response rates: In total, 85% of parent questionnaires were returned and 100% of paediatric physiotherapists responded.
Results: Service use among families was high; on average the families had contact with approximately seven services in a 6-month time interval. The overwhelming majority of children (96%) received physiotherapy during the school term and most (59%) received treatment at least twice a week for 30 min; 43% of children had their physiotherapy discontinued over the summer holidays. Over one-quarter (28%) of families had opted out of the NHS and bought alternatives like conductive education (21%) or private forms of conventional physiotherapy (16%). Children with more severe forms of CP, in special education, particularly at schools for physical disability, were high-intensity users of the physiotherapy service. Despite this, 74% of parents wanted more physiotherapy for their child.
Conclusions and implications: The demand for physiotherapy services is likely to continue given the relatively stable prevalence rate of CP, the proportion of children with disabling CP and the level of parent interest in the service. A number of quality aspects and gaps in the service have been identified.

Inference and Declaration of Independence in Task-Parallel Programs

The inherent difficulty of thread-based shared-memory programming has recently motivated research in high-level, task-parallel programming models. Recent advances of Task-Parallel models add implicit synchronization, where the system automatically detects and satisfies data dependencies among spawned tasks. However, dynamic dependence analysis incurs significant runtime overheads, because the runtime must track task resources and use this information to schedule tasks while avoiding conflicts and races.
We present SCOOP, a compiler that effectively integrates static and dynamic analysis in code generation. SCOOP combines context-sensitive points-to, control-flow, escape, and effect analyses to remove redundant dependence checks at runtime. Our static analysis can work in combination with existing dynamic analyses and task-parallel runtimes that use annotations to specify tasks and their memory footprints. We use our static dependence analysis to detect non-conflicting tasks and an existing dynamic analysis to handle the remaining dependencies. We evaluate the resulting hybrid dependence analysis on a set of task-parallel programs.

Power and the Construction of Independence in ICTD Organizations

How do powerful vested interests continue to influence ICT for development (ICTD) projects? In this paper, instead of adopting a macro-level analysis, I take an in-depth, ethnographic approach to focus on work practices at one NGO involved in producing information and communication technologies for use in developing countries. Staff decisions at this NGO were influenced by particular powerful organizations, and I draw on theoretical insights from organization studies in order to understand this. The approach yields surprising results. Staff members appeared able to "stand back" from the pressures coming from donors and other influential parties, and to critically reflect upon these. Paradoxically, rather than fueling resistance, this sense of independence appeared to reinforce dependency on these powerful organizations. Moreover, the fact that this NGO was engaged in ICTD work further heightened these effects. This study extends existing understandings of how power operates within ICTD organizations, by highlighting the ways in which a sense of independence can paradoxically exacerbate donor influence over work activities.

'"These schemes will win for themselves the confidence of the people": Irish independence, poor law reform and hospital provision'

This article examines hospital provision in Ireland during the early twentieth century. It examines attempts by the newly independent Irish Free State to reform and de-stigmatise medical relief in former workhouse infirmaries. Such reforms were designed to move away from nineteenth century welfare regimes which were underpinned by principles of deterrence. The reform initiated in independent Ireland - the first attempted break-up of the New Poor Law in Great Britain or Ireland - was partly successful. Many of the newly named County and District Hospitals provided solely for medical cases and managed to dissociate such health care provision from the relief of poverty. However, some hospitals continued to act as multifunctional institutions and provided for various categories including the sick, the aged and infirm, 'unmarried mothers' and 'harmless lunatics'. Such institutions often remained associated with the relief of poverty. This article also examines patient fee-payment and outlines how fresh terms of entitlement and means-testing were established. Such developments were even more pronounced in voluntary hospitals where the majority of patients made a financial contribution to their treatment. The article argues that the ability to pay at times determined the type of provision, either voluntary or rate-aided, available to the sick. However, it concludes that the clinical condition of patients often determined whether they entered a more prestigious voluntary hospital or the former workhouse. Although this article concentrates on two Irish case studies, County Kerry and Cork City; it is conceptualised within wider developments with particular reference to the British context.