« Enseigner les lettres au XIXe siècle. Histoire sociale et politique comparée des professeurs de lettres de l'enseignement secondaire public en Belgique et en Italie (1850-1914) »

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« La langue, l’école et la nation. Histoire sociale et politique comparée des professeurs de lettres de l’enseignement secondaire public en Belgique et en Italie, 1850-1914 »

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Interstitial insertion of varying amounts of ABL-containing genetic material into chromosome 22 in Ph-negative CML.

We studied the cells from three selected patients with Ph-chromosome-negative chronic myeloid leukemia (CML) by Southern blotting, polymerase chain reaction, and in situ hybridization of informative probes to metaphase chromosomes. All three patients had rearrangement of M-BCR sequences in the BCR gene and expression of one or other of the mRNA species characteristic of Ph-positive CML. Leukemic metaphases studied after trypsin-Giemsa banding were indistinguishable from normal. The ABL probe localized both to chromosome 9 and 22 in each case. A probe containing 3' M-BCR sequences localized only to chromosome 22, and not to chromosome 9 as would be expected in Ph-positive CML. Two new probes that recognize different polymorphic regions distal to the ABL gene on chromosome 9 in normal subjects localized exclusively to chromosome 9 in two patients and to both chromosomes 9 and 22 in one patient. These results show that Ph-negative CML with BCR rearrangement is associated with insertion of a variable quantity of chromosome 9 derived material into chromosome 22q11; there is no evidence for reciprocal translocation of material from chromosome 22 to chromosome 9.

Les discriminations au travail dues à l’orientation sexuelle et les identités de genre

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Fernand Dufrasne, poète et chantre de l'âme boraine

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