1 resultado para Fragility
em DI-fusion - The institutional repository of Université Libre de Bruxelles
Filtro por publicador
- University of Cagliari UniCA Eprints (1)
- ABACUS. Repositorio de Producción Científica - Universidad Europea (1)
- Academic Research Repository at Institute of Developing Economies (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (3)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (2)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (2)
- Andina Digital - Repositorio UASB-Digital - Universidade Andina Simón Bolívar (2)
- Aquatic Commons (6)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (5)
- Archive of European Integration (8)
- Archivo Digital para la Docencia y la Investigación - Repositorio Institucional de la Universidad del País Vasco (2)
- Aston University Research Archive (6)
- Biblioteca de Teses e Dissertações da USP (4)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (2)
- Biblioteca Digital da Câmara dos Deputados (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (8)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (5)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (17)
- Bioline International (1)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (21)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- CaltechTHESIS (2)
- Cambridge University Engineering Department Publications Database (7)
- CentAUR: Central Archive University of Reading - UK (4)
- Center for Jewish History Digital Collections (17)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (2)
- Cochin University of Science & Technology (CUSAT), India (2)
- Coffee Science - Universidade Federal de Lavras (1)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (6)
- CORA - Cork Open Research Archive - University College Cork - Ireland (2)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (2)
- Deakin Research Online - Australia (46)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons - Michigan Tech (2)
- DigitalCommons@The Texas Medical Center (3)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (1)
- DRUM (Digital Repository at the University of Maryland) (1)
- Duke University (1)
- FUNDAJ - Fundação Joaquim Nabuco (3)
- Harvard University (107)
- Helda - Digital Repository of University of Helsinki (2)
- Illinois Digital Environment for Access to Learning and Scholarship Repository (1)
- Indian Institute of Science - Bangalore - Índia (22)
- Instituto Politécnico de Viseu (2)
- Instituto Politécnico do Porto, Portugal (3)
- Instituto Superior de Psicologia Aplicada - Lisboa (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (1)
- Memoria Académica - FaHCE, UNLP - Argentina (12)
- National Center for Biotechnology Information - NCBI (5)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (2)
- Portal de Revistas Científicas Complutenses - Espanha (3)
- Publishing Network for Geoscientific & Environmental Data (2)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (20)
- Queensland University of Technology - ePrints Archive (23)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- RDBU - Repositório Digital da Biblioteca da Unisinos (1)
- REPOSITÓRIO ABERTO do Instituto Superior Miguel Torga - Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (5)
- Repositório digital da Fundação Getúlio Vargas - FGV (16)
- Repositório Institucional da Universidade de Aveiro - Portugal (6)
- Repositório Institucional da Universidade de Brasília (3)
- Repositório Institucional da Universidade Estadual de São Paulo - UNESP (2)
- Repositório Institucional da Universidade Federal do Rio Grande - FURG (1)
- Repositório Institucional da Universidade Federal do Rio Grande do Norte (3)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (117)
- Repositorio Institucional Universidad de Medellín (1)
- Royal College of Art Research Repository - Uninet Kingdom (1)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (1)
- SAPIENTIA - Universidade do Algarve - Portugal (1)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (2)
- Scielo España (1)
- Scientific Open-access Literature Archive and Repository (1)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (14)
- Universidad Politécnica de Madrid (6)
- Universidade de Lisboa - Repositório Aberto (3)
- Universidade Federal de Uberlândia (1)
- Universidade Federal do Pará (15)
- Universidade Federal do Rio Grande do Norte (UFRN) (54)
- Universidade Metodista de São Paulo (7)
- Universidade Técnica de Lisboa (1)
- Universita di Parma (1)
- Universitat de Girona, Spain (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (1)
- Université de Lausanne, Switzerland (3)
- Université de Montréal (1)
- Université de Montréal, Canada (14)
- University of Michigan (1)
- University of Queensland eSpace - Australia (6)
- University of Washington (2)
Resumo:
We studied the pattern of BCR involvement in 52 patients with chronic myeloid leukemia by Southern blotting. Of 33 Philadelphia (Ph)-positive patients, 30 had evidence of M-BCR rearrangement, two cases were difficult to interpret, and one clearly lacked evidence of M-BCR rearrangement. Of 19 Ph-negative patients, nine showed M-BCR rearrangement, nine showed no rearrangement, and one result was uncertain. We selected for more detailed study eight patients (three Ph-positive and five Ph-negative). Two of the Ph-positive patients, whose Southern blots were difficult to interpret, had rearranged bands when the BCR gene was studied by pulsed field gel electrophoresis (PFGE). Results of PFGE studies and in situ hybridization to metaphase chromosomes in the third Ph-positive patient, whose DNA clearly lacked M-BCR rearrangement on Southern analysis, were consistent with a breakpoint on chromosome 22 located 3' of all known exons of the BCR gene. However, mRNA studied with the polymerase chain reaction showed evidence of a classical b2-a2 linkage. The findings in this patient may be explained by an unusual genomic breakpoint downstream of the BCR gene associated with long range splicing that excluded all of the 3' BCR exons. Of the five patients with Ph-negative M-BCR non-rearranged CML studied by PFGE for BCR gene rearrangement, none had evidence of rearranged bands. We conclude that PFGE is a valuable adjunct to standard molecular techniques for the study of atypical cases of CML. Occasional patients with Ph-positive CML have breakpoints outside M-BCR. The BCR gene is probably not involved in patients with Ph-negative, M-BCR non-rearranged CML.