Reductive Amination Reaction

A simple, solventless procedure for reductive amination that results in an impressive color change. Reaction proceeds in three stages: imine formation, reduction, and acetylation and purification is done by crystallization.

Forensic analysis of analgesics by TLC

An introductory laboratory on the identification of analgesics in an unknown sample. Ideal for the first week of an organic chemistry sequence to get students familiar with their surroundings. Students extract, isolate, and perform thin layer chromatography on aspirin, acetominophen, or ibuprofen.

Borohydride Reduction of Fluorenone

A simple experiment to demonstrate nucleophilic addition to a carbonyl. Sodium borohydride-mediated reduction of fluorenone is a fast and high-yielding reaction that is suitable for beginning students. Students isolate their fluorenol product by recrystallization and characterize it by NMR and IR.

Grignard Reaction - Synthesis of Substituted Benzoic Acids

A convenient preparation of substituted benzoic acids from Grignard additions to solid carbon dioxide. Students create a library of carboxylic acids by using differentially substituted, commercially available aryl bromides, which can be used as the starting materials for a multistep synthesis. This is a modification and improvement of a very popular undergraduate organic chemistry experiment.