Grignard Reaction - Synthesis of Substituted Benzoic Acids
| Data(s) |
11/10/2011
11/10/2011
11/10/2011
|
|---|---|
| Resumo |
A convenient preparation of substituted benzoic acids from Grignard additions to solid carbon dioxide. Students create a library of carboxylic acids by using differentially substituted, commercially available aryl bromides, which can be used as the starting materials for a multistep synthesis. This is a modification and improvement of a very popular undergraduate organic chemistry experiment. |
| Identificador | |
| Idioma(s) |
en_US |
| Direitos |
Attribution Non-Commercial Share-Alike 3.0 Unported http://creativecommons.org/licenses/by-nc-sa/3.0/ |
| Palavras-Chave | #Organomagnesium reagent #Separation #Library of carboxylic acids #Grignard reaction #Benzoic acid #Dry ice #Infrared spectroscopy (IR) #Nuclear magnetic resonance spectroscopy (NMR) #Liquid-liquid extraction #Use of dry glassware #Carbon dioxide #Nucleophilic addition to carbonyl #Vacuum filtration |
