Combined oral contraceptives and increasing cardiovascular risk: thromboembolism and hypertension

Background: Hormonal contraceptive pills are the most used reversible method for familiar planning in Brazil. The combined pill, with synthetic analogs of estrogen and progestin, is employed by 25% of Brazilian female population. Its use provokes an increase of blood pressure levels, takes patient to a hipercoagulability state and predisposes her to thromboembolic events. Purposes: We aimed to describe mechanisms of hypercoagulability promoted by oral combined contraceptives, to analyze the relative risk of cardiovascular events within users and to list the most common circulatory pathologies in these patients. Methods: Three virtual medical databases were surveyed (Pubmed/Medline, BVS/LILACS and Scielo). Twelve studies were selected: clinical trials, case reports and articles of indexed medical periodic originally published in Portuguese and English about synthetic hormones, oral contraception, coagulation disorders and cardiovascular morbimortality. Results: Synthetic estrogen promotes an increase of some clotting factors' levels (VII, VIII, IX, X, XII, XIII and fibrinogen), such as a reduction of their inhibitors (S protein and antithrombin). Because of this, etinilestradiol is the component most related to venous thrombosis and ischemic diseases of brain and heart. It also improves the releasing of hepatic angiotensinogen, taking to a increase of blood pressure levels. Conclusions: The prescription of oral combined contraceptives needs criteria, notably due to adverse effects of etinilestradiol. It is recommended to avoid the administration of these drugs for patients elder than 35 year-old or with risk factors. For these patients, the use of progestagen-only pills seems to be safer.

Competência informacional e midiática no ensino superior: Desafios e propostas para o Brasil

A presença das tecnologias e das mídias é hoje tão importante, que é impossível ignorá-la. Os calouros e estudantes universitários de hoje têm telefones celulares com fotos digitais e ídeos. Eles usam blogs, twitter e sites de redes sociais. Ao mesmo tempo, leem livros e artigos, e fazem seus projetos e a lição de casa. Continuamente, diferentes tecnologias e novas informações estão impactando o ensino superior. Isto exige uma rápida atualização da competência informacional e midiática pelos alunos. Apesar do impacto progressivo da tecnologia digital na cultura acadêmica contemporânea, é imperativo resgatar e consolidar um compromisso mais crítico com a informação, mídia e tecnologia. Nós defendemos a convergência da literacia da informação e da literacia dos media no ensino superior. O Projeto CIMES (Competência em Informação e Mídia no Ensino Superior) está em estágio inicial. O presente artigo tem como objetivo revisar as questões teóricas, políticas e práticas sobre a educação para a competência em informação e mídia no ensino superior, especialmente no Brasil. O objetivo final do Projeto CIMES é fornecer uma estrutura para desenvolver programas educacionais no Brasil que tenham a competência em informação e a competência midiática como uma aplicação transversal no ensino superior. O atual estágio do projeto permite apenas traçar um quadro geral analítico

Essays on the history of Brazilian dipterology. III. Three remarkable notices from the 18th century, mainly related to myiasis-producing flies (Cochliomyia and Dermatobia)

Essays on the history of Brazilian dipterology. III. Three remarkable notices from the 18th century, mainly related to myiasis-producing flies (Cochliomyia and Dermatobia). This paper registers reports about dipterans made by three Portuguese who lived in Brazil during the 18th century. Luiz Gomes Ferreira, in his book "Erario mineral" ["Mineral revenue"], wrote curious passages related with myiasis-causing flies of the genus Cochliomyia. Jose Rodrigues de Mello registered, in Latin verses, the folklore for curing myiases caused by Cochliomyia hominivorax in cattle. Luiz dos Santos Vilhena, in the last of his twenty letters dealing with several aspects of life in Brazil, made reference to horseflies, human bot flies and mosquitos.

Essays on the history of brazilian dipterology: III. Three remarkable notices from the 18th century, mainly related to myiasis-producing flies (Cochliomyia and Dermatobia)

This paper registers reports about dipterans made by three Portuguese who lived in Brazil during the 18th century. Luiz Gomes Ferreira, in his book "Erário mineral" ["Mineral revenue"], wrote curious passages related with myiasis-causing flies of the genus Cochliomyia. José Rodrigues de Mello registered, in Latin verses, the folklore for curing myiases caused by Cochliomyia hominivorax in cattle. Luiz dos Santos Vilhena, in the last of his twenty letters dealing with several aspects of life in Brazil, made reference to horseflies, human bot flies and mosquitos.