Sistema de predição de avarias em máquinas de unidades fabris globalmente dispersas

Tese de Doutoramento Ramo Engenharia Industrial e de Sistemas

Perspetivas de pais acerca da inclusão de alunos com transtornos do espectro do autismo na escola regular, da rede estadual de ensino da zona leste da cidade de Manaus - Amazonas, Brasil

Dissertação de mestrado em Educação Especial (área de especialização em Dificuldades de Aprendizagem Específicas)

Gestão da manutenção de edifícios em unidades hospitalares

Dissertação de mestrado em Construção e Reabilitação Sustentáveis

Compromisso organizacional e satisfação com o trabalho: um estudo com duas unidades hoteleiras portuguesas

Dissertação de mestrado integrado em Psicologia

The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a marked decline in cognition and memory function. Increasing evidence highlights the essential role of neuroinflammatory and immune-related molecules, including those produced at the brain barriers, on brain immune surveillance, cellular dysfunction and amyloid beta (Aß) pathology in AD. Therefore, understanding the response at the brain barriers may unravel novel pathways of relevance for the pathophysiology of AD. Herein, we focused on the study of the choroid plexus (CP), which constitutes the blood-cerebrospinal fluid barrier, in aging and in AD. Specifically, we used the PDGFB-APPSwInd (J20) transgenic mouse model of AD, which presents early memory decline and progressive Aß accumulation, and littermate age-matched wild-type (WT) mice, to characterize the CP transcriptome at 3, 5-6 and 11-12months of age. The most striking observation was that the CP of J20 mice displayed an overall overexpression of type I interferon (IFN) response genes at all ages. Moreover, J20 mice presented a high expression of type II IFN genes in the CP at 3months, which became lower than WT at 5-6 and 11-12months. Importantly, along with a marked memory impairment and increased glial activation, J20 mice also presented a similar overexpression of type I IFN genes in the dorsal hippocampus at 3months. Altogether, these findings provide new insights on a possible interplay between type I and II IFN responses in AD and point to IFNs as targets for modulation in cognitive decline.

Metodologia da investigação em cibercultura I: Design da pesquisa

Linguagem da Ciência e a problematização na área da Cibercultura: O objecto de estudos científico; conceitos e teoria; Conceitos principais; A validade dos conceitos; Metodologia e técnicas sociológicas; Fontes da pesquisa; Agenda da pesquisa; Metodologias Sociológicas clássicas e emergentes; Métodos e técnicas de pesquisa sobre a Cibercultura; Exemplo de um projeto de investigação: a Comunicação Pública da Arte em museus físicos e virtuais.

Espacialidade e temporalidades da cibercultura I: Controlo e vigilância na Mediapolis

Ciberespaço e o cibertempo na vida quotidiana urbana: Controlo e vigilância na Mediapolis; Michel Foucault; Pós-panoptismos e novas virtualidades do presente urbano. Exemplo de projeto de investigação: ‘Saberes, poderes e vigilâncias nos espaços e tempos urbanos’ - O autor Michel Foucault; - Pesquisa bibliográfica; -Pesquisa histórica; - Pesquisa documental; - Pesquisa sociológica / antropológica.

All over the place localization system

The MAP-i Doctoral Programme in Informatics, of the Universities of Minho, Aveiro and Porto

Desenvolvimento de um laboratório pedagógico de vias de comunicação na Universidade do Minho

Dissertação de mestrado integrado em Engenharia Civil

Aplicação da metodologia ROC na avaliação de desempenho de índices de gravidade clínica em unidades de neonatologia de Portugal

Tese de Doutoramento em Engenharia Industrial e de Sistemas

Supercritical fluid and pharmaceutical applications. Part I: Process classification

The supercritical fluid technology has been target of many pharmaceuticals investigations in particles production for almost 35 years. This is due to the great advantages it offers over others technologies currently used for the same purpose. A brief history is presented, as well the classification of supercritical technology based on the role that the supercritical fluid (carbon dioxide) performs in the process.

Micro/nano-structured superhydrophobic surfaces in the biomedical field: part I: basic concepts and biomimetic approaches.

Inspired by natural structures, great attention has been devoted to the study and development of surfaces with extreme wettable properties. The meticulous study of natural systems revealed that the micro/nano-topography of the surface is critical to obtaining unique wettability features, including superhydrophobicity. However, the surface chemistry also has an important role in such surface characteristics. As the interaction of biomaterials with the biological milieu occurs at the surface of the materials, it is expected that synthetic substrates with extreme and controllable wettability ranging from superhydrophilic to superhydrophobic regimes could bring about the possibility of new investigations of cellâ material interactions on nonconventional surfaces and the development of alternative devices with biomedical utility. This first part of the review will describe in detail how proteins and cells interact with micro/nano-structured surfaces exhibiting extreme wettabilities.