Longitudinal analysis of tumor marker CEA of breast cancer patients from Braga's hospital

Allied to an epidemiological study of population of the Senology Unit of Braga’s Hospital that have been diagnosed with malignant breast cancer, we describe the progression in time of repeated measurements of tumor marker Carcinoembryonic antigen (CEA). Our main purpose is to describe the progression of this tumor marker as a function of possible risk factors and, hence, to understand how these risk factors influences that progression. The response variable, values of CEA, was analyzed making use of longitudinal models, testing for different correlation structures. The same covariates used in a previous survival analysis were considered in the longitudinal model. The reference time used was time from diagnose until death from breast cancer. For diagnostic of the models fitted we have used empirical and theoretical variograms. To evaluate the fixed term of the longitudinal model we have tested for a changing point on the effect of time on the tumor marker progression. A longitudinal model was also fitted only to the subset of patients that died from breast cancer, using the reference time as time from date of death until blood test.

Using data mining for prediction of hospital length of stay: an application of the CRISP-DM Methodology

Hospitals are nowadays collecting vast amounts of data related with patient records. All this data hold valuable knowledge that can be used to improve hospital decision making. Data mining techniques aim precisely at the extraction of useful knowledge from raw data. This work describes an implementation of a medical data mining project approach based on the CRISP-DM methodology. Recent real-world data, from 2000 to 2013, were collected from a Portuguese hospital and related with inpatient hospitalization. The goal was to predict generic hospital Length Of Stay based on indicators that are commonly available at the hospitalization process (e.g., gender, age, episode type, medical specialty). At the data preparation stage, the data were cleaned and variables were selected and transformed, leading to 14 inputs. Next, at the modeling stage, a regression approach was adopted, where six learning methods were compared: Average Prediction, Multiple Regression, Decision Tree, Artificial Neural Network ensemble, Support Vector Machine and Random Forest. The best learning model was obtained by the Random Forest method, which presents a high quality coefficient of determination value (0.81). This model was then opened by using a sensitivity analysis procedure that revealed three influential input attributes: the hospital episode type, the physical service where the patient is hospitalized and the associated medical specialty. Such extracted knowledge confirmed that the obtained predictive model is credible and with potential value for supporting decisions of hospital managers.

Economic evaluation of occupational safety preventive measures in a hospital

BACKGROUND: When an organization performs an integrated analysis of risks through its Occupational Health and Safety Management System, several steps are suggested to address the implications of the identified risks. Namely, the organization should make a detailed analysis of the monetary impact for the organization of each of the preventive measures considered. However, it is also important to perform an analysis of the impact of each measure on society (externalities). OBJECTIVE: The aim of this paper is to present a case study related to the application of the proposed economic evaluation methodology. METHODS: An analysis of the work accidents in a hospital has been made. Three of the major types of accidents have been selected: needle stings, falls and excessive strain. Following the risk assessment, some preventive measures have been designed. Subsequently, the Benefit/Cost ratio (B/C) of these measures has been calculated, both in financial terms (from the organization’s perspective) and in economic terms (including the benefits for the worker and for the Society). RESULTS: While the financial ratio is only advantageous in some cases, when the externalities are taken into account, the B/C ratio increases significantly. CONCLUSIONS: It is important to consider external

Qualitative risk assessment during polymer mortar test specimens preparation - methods comparison

Polymer binder modification with inorganic nanomaterials (NM) could be a potential and efficient solution to control matrix flammability of polymer concrete (PC) materials without sacrificing other important properties. Occupational exposures can occur all along the life cycle of a NM and “nanoproducts” from research through scale-up, product development, manufacturing, and end of life. The main objective of the present study is to analyse and compare different qualitative risk assessment methods during the production of polymer mortars (PM) with NM. The laboratory scale production process was divided in 3 main phases (pre-production, production and post-production), which allow testing the assessment methods in different situations. The risk assessment involved in the manufacturing process of PM was made by using the qualitative analyses based on: French Agency for Food, Environmental and Occupational Health & Safety method (ANSES); Control Banding Nanotool (CB Nanotool); Ecole Polytechnique Fédérale de Lausanne method (EPFL); Guidance working safely with nanomaterials and nanoproducts (GWSNN); Istituto Superiore per la Prevenzione e la Sicurezza del Lavoro, Italy method (ISPESL); Precautionary Matrix for Synthetic Nanomaterials (PMSN); and Stoffenmanager Nano. It was verified that the different methods applied also produce different final results. In phases 1 and 3 the risk assessment tends to be classified as medium-high risk, while for phase 2 the more common result is medium level. It is necessary to improve the use of qualitative methods by defining narrow criteria for the methods selection for each assessed situation, bearing in mind that the uncertainties are also a relevant factor when dealing with the risk related to nanotechnologies field.

Enteroscopia por cápsula e doença de Crohn: Caminhos para a otimização

Tese de Doutoramento em Medicina

Relatório sobre “Surgical cases packages”

Problema apresentado pelo Hospital de Braga no 109th European Study Group with Industry 10 a 15 de maio de 2015. Departamento de Produção e Sistemas Escola de Engenharia da Universidade do Minho Guimarães Portugal 24 de julho de 2015

Cultura e educação indígena: limites do currículo escolar

Este trabalho traz uma reflexão sobre a Educação Indígena no Brasil, com base em dados históricos e estatísticos, de forma a melhor compreender e adequar o currículo escolar às diferentes realidades contextuais. Compreender a educação dos índios nos dias atuais requer uma breve recomposição da historicidade desse povo. Exige o reconhecimento dos 500 anos de história do Brasil, onde os povos indígenas foram expostos a um violento processo civilizatório que implicou em transformações na cultura e identidade desses povos. Mesmo com o desenvolvimento de política de proteção ao índio e com leis voltadas para lhes assegurar a cidadania, observa-se um quadro de exclusão social e cultural.. Entretanto, a cidadania indígena vem sendo negada ao mesmo tempo em que se legitimam discursos de respeito à diversidade e a diferença. A Escola indígena específica e diferenciada surge como um projeto pensado pelos movimentos indígenas com a finalidade de reparar a lacuna existente na história da educação nacional.

O quotidiano do hospital de S. Marcos de Braga na Idade Moderna

Instituição administrada pela Misericórdia de Braga desde meados do século XVI, o hospital de S. Marcos tornou-se ao longo da Idade Moderna um importante local de tratamento ao corpo e de salvação da alma para doentes pobres, recebendo enfermos de todo o arcebispado, mas também de outras partes do reino e mesmo do estrangeiro. Os cuidados prestados ao corpo e à alma exigiam equipas de trabalho, a aquisição de bens e uma administração que fizesse cumprir as regras existentes. O nosso estudo procurará analisar as relações de sociabilidade existentes no interior do hospital, a aquisição de bens, nomeadamente para as enfermarias, a cozinha e a igreja, a alimentação dos enfermos, os cuidados médicos e a caridade dispensada a quem estava doente e era pobre. Pretende-se dar a conhecer o funcionamento e as vivências de uma instituição que, progressivamente, foi ocupando um lugar cada vez mais importante na cidade.

Otimização do internamento no Hospital de Braga usando metodologia Kaizen

Dissertação de mestrado integrado em Engenharia Biomédica (área de especialização em Engenharia Clínica)

Avaliação de conhecimentos sobre cancro da mama na região Porto Ocidental

Dissertação de mestrado em Estatística

Estudo comparativo entre indicadores de desempenho da JCI e do Contrato Programa Cirurgia Segura

Dissertação de mestrado em Engenharia e Gestão da Qualidade

Joint modelling of longitudinal and survival data on breast cancer

Tese de Doutoramento em Ciências (Especialidade em Matemática)

Continuous fungal treatment of non-sterile veterinary hospital effluent: pharmaceuticals removal and microbial community assessment

Source point treatment of effluents with a high load of pharmaceutical active compounds (PhACs), such as hospital wastewater, is a matter of discussion among the scientific community. Fungal treatments have been reported to be successful in degrading this type of pollutants and, therefore, the white-rot fungus Trametes versicolor was applied for the removal of PhACs from veterinary hospital wastewater. Sixty-six percent removal was achieved in a non-sterile batch bioreactor inoculated with T. versicolor pellets. On the other hand, the study of microbial communities by means of DGGE and phylogenetic analyses led us to identify some microbial interactions and helped us moving to a continuous process. PhAC removal efficiency achieved in the fungal treatment operated in non-sterile continuous mode was 44 % after adjusting the C/N ratio with respect to the previously calculated one for sterile treatments. Fungal and bacterial communities in the continuous bioreactors were monitored as well.

Coordenação das MEP na implementação de modelos BIM

Dissertação de mestrado integrado em Engenharia Civil