75 resultados para improvements


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Dissertação de mestrado integrado em Engenharia e Gestão Industrial

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Dissertação de mestrado em Engenharia e Gestão da Qualidade

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Dissertação de mestrado integrado em Engenharia e Gestão Industrial

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Alzheimer's disease (AD) is commonly associated with marked memory deficits; however, nonamnestic variants have been consistently described as well. Posterior cortical atrophy (PCA) is a progressive degenerative condition in which posterior regions of the brain are predominantly affected, therefore resulting in a pattern of distinctive and marked visuospatial symptoms, such as apraxia, alexia, and spatial neglect. Despite the growing number of studies on cognitive and neural bases of the visual variant of AD, intervention studies remain relatively sparse. Current pharmacological treatments offer modest efficacy. Also, there is a scarcity of complementary nonpharmacological interventions with only two previous studies of PCA. Here we describe a highly educated 57-year-old patient diagnosed with a visual variant of AD who participated in a cognitive intervention program (comprising reality orientation, cognitive stimulation, and cognitive training exercises). Neuropsychological assessment was performed across moments (baseline, postintervention, follow-up) and consisted mainly of verbal and visual memory. Baseline neuropsychological assessment showed deficits in perceptive and visual-constructive abilities, learning and memory, and temporal orientation. After neuropsychological rehabilitation, we observed small improvements in the patient's cognitive functioning, namely in verbal memory, attention, and psychomotor abilities. This study shows evidence of small beneficial effects of cognitive intervention in PCA and is the first report of this approach with a highly educated patient in a moderate stage of the disease. Controlled studies are needed to assess the potential efficacy of cognition-focused approaches in these patients, and, if relevant, to grant their availability as a complementary therapy to pharmacological treatment and visual aids.

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Dissertação de mestrado integrado em Engenharia e Gestão Industrial

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Dissertação de mestrado integrado em Engenharia e Gestão Industrial

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Tese de Doutoramento em Engenharia Química e Biológica (área de conhecimento em Engenharia Enzimática e das Fermentações)

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Dissertação de mestrado em Engenharia Industrial

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Dissertação de mestrado integrado em Engenharia Mecânica

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Dissertação de mestrado integrado em Engenharia Eletrónica Industrial e Computadores

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Dissertação de mestrado integrado em Engenharia Biomédica (área de especialização em Eletrónica Médica)

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Dissertação de mestrado em Biologia Molecular, Biotecnologia e Bioempreendedorismo em Plantas

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Several studies have linked deindividuation to an increase in aggression and incivility. This paper seeks to ascertain the influence of anonymity and hierarchy in online aggression by comparing two different newspaper comment sections: one with a hierarchical system and the other with an equalitarian setting. This study distinguishes itself form previous works by analyzing systems where identification is optional and where identified and anonymous users coexist. The hierarchical solution might be relevant to dissuade aggression when optional identifiability is seen as an essential asset. Results show that a hierarchical system provides some improvements in terms of civility and comment moderation, but that poor implementation of the hierarchy causes perversions in the system and affects its effectiveness.

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Dissertação de mestrado em Bioquímica Aplicada (área de especialização em Biomedicina)

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Silk fibroin is a commonly available natural biopolymer produced in specialized glands of arthropods, such as silkworms or spiders, scorpions, mites, bees and flies. This biopolymer has a long history of use in textile production and also as sutures or treatment of skin wounds. Silk fibroin has been increasingly explored in other areas of biomedical science where we can find a higher morphological diversification of silk biomaterials like films, electrospun fibers, 3D porous scaffolds or nanoparticles. In recent years it has been demonstrated that fibroin is an excellent material for active components in optical devices. This new application opens the way towards the development of multifunctional optoelectronic devices, which in perspective can be made fully biocompatible and eventually bioresorbable. Moreover, fibroin can be added to other biocomponents in order to modify the biomaterial properties leading to optimized and total different functions. These improvements can go from higher cell adhesion in tissue engineering or enhanced optical transparency, smoothness or flexibility in optoelectronic devices. The tuning and completely understanding of silk fibers physicochemical properties and interaction with other elements are of crucial importance for the improvement of already existent silk-based materials and the basis for the development of new products.