41 resultados para José Baptista de Sousa


Relevância:

20.00% 20.00%

Publicador:

Resumo:

"Lecture notes in computer science series", ISSN 0302-9743, vol. 9121

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Stress exposure triggers cognitive and behavioral impairments that influence decision-making processes. Decisions under a context of uncertainty require complex reward-prediction processes that are known to be mediated by the mesocorticolimbic dopamine (DA) system in brain areas sensitive to the deleterious effects of chronic stress, in particular the orbitofrontal cortex (OFC). Using a decision-making task, we show that chronic stress biases risk-based decision-making to safer behaviors. This decision-making pattern is associated with an increased activation of the lateral part of the OFC and with morphological changes in pyramidal neurons specifically recruited by this task. Additionally, stress exposure induces a hypodopaminergic status accompanied by increased mRNA levels of the dopamine receptor type 2 (Drd2) in the OFC; importantly, treatment with a D2/D3 agonist quinpirole reverts the shift to safer behaviors induced by stress on risky decision-making. These results suggest that the brain mechanisms related to risk-based decision-making are altered after chronic stress, but can be modulated by manipulation of dopaminergic transmission.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Inter-individual heterogeneity is evident in aging; education level is known to contribute for this heterogeneity. Using a cross-sectional study design and network inference applied to resting-state fMRI data, we show that aging was associated with decreased functional connectivity in a large cortical network. On the other hand, education level, as measured by years of formal education, produced an opposite effect on the long-term. These results demonstrate the increased brain efficiency in individuals with higher education level that may mitigate the impact of age on brain functional connectivity.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Dissertação de mestrado em Relações Internacionais

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Relatório de estágio de mestrado em Ensino de Informática

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Dissertação de mestrado em Ecology

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Relatório de estágio de mestrado em Ensino de Informática

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Dissertação de mestrado em Educação Especial (área de especialização em Intervenção Precoce)

Relevância:

20.00% 20.00%

Publicador:

Resumo:

In recent decades, an increased interest has been evidenced in the research on multi-scale hierarchical modelling in the field of mechanics, and also in the field of wood products and timber engineering. One of the main motivations for hierar-chical modelling is to understand how properties, composition and structure at lower scale levels may influence and be used to predict the material properties on a macroscopic and structural engineering scale. This chapter presents the applicability of statistic and probabilistic methods, such as the Maximum Likelihood method and Bayesian methods, in the representation of timber’s mechanical properties and its inference accounting to prior information obtained in different importance scales. These methods allow to analyse distinct timber’s reference properties, such as density, bending stiffness and strength, and hierarchically consider information obtained through different non, semi or destructive tests. The basis and fundaments of the methods are described and also recommendations and limitations are discussed. The methods may be used in several contexts, however require an expert’s knowledge to assess the correct statistic fitting and define the correlation arrangement between properties.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Dissertação de mestrado integrado em Arquitectura (área de especialização em Cultura Arquitectónica)