53 resultados para Reach.


Relevância:

10.00% 10.00%

Publicador:

Resumo:

Dissertação de mestrado em Economia Industrial e da Empresa

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Dissertação de mestrado integrado em Engenharia Eletrónica Industrial e de Computadores

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Dissertação de mestrado integrado em Mechanical Engineering

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Urothelial bladder carcinoma (UBC) is an intricate malignancy with a variable natural history and clinical behavior. Despite developments in diagnosis/prognosis refinement and treatment modalities, the recurrence rate is high, and progression from non-muscle to muscle invasive UBC commonly leads to metastasis. Moreover, patients with muscle-invasive or extra-vesical disease often fail the standard chemotherapy treatment, and overall survival rates are poor. Thus, UBC remains a challenge in the oncology field, representing an ideal candidate for research on biomarkers that could identify patients at increased risk of recurrence, progression, and chemo-refractoriness. However, progress toward personalized medicine has been hampered by the unique genetic complexity of UBC. Recent genome-wide expression and sequencing studies have brought new insights into its molecular features, pathogenesis and clinical diversity, revealing a landscape where classical pathology is intersected by the novel and heterogeneous molecular groups. Hence, it seems plausible to postulate that only an integrated signature of prognostic/predictive biomarkers inherent in different cancer hallmarks will reach clinical validation. In this review, we have summarized ours and others' research into novel putative biomarkers of progression and chemoresistance that encompass several hallmarks of cancer: tumor neovascularization, invasion and metastasis, and energy metabolism reprogramming of the tumor microenvironment.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Dissertação de mestrado em Ciências - Formação Contínua de Professores (área de especialização em Biologia e Geologia)

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Dissertação de mestrado em Biofísica e Bionanossistemas

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Dissertação de mestrado integrado em Engenharia e Gestão de Sistemas de Informação

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Dissertação de mestrado em Design de Comunicação de Moda

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Tese de Doutoramento em Ciências da Educação (Especialidade de Tecnologia Educativa)

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Recently, environmental architecture and sustainable construction has been ranked on top of the worldâ s interests. Making use of natural resources helps in reducing energy consumption and costs associated with the operation of buildings. The current architectural approaches and designs in Palestine are far away from environmental concepts, copying and simulating abroad approaches, without taking into account the culture, climate, and inhabitant's needs. On the contrast, vernacular architecture has achieved environmental concepts and has given suitable approaches and samples - without any need to simulate or copy - which come from people and land. This paper discusses how the Palestinian socio-cultural context shaped the residential vernacular architecture in Palestine, taking the old city of Nablus as a case-study. The research concept depends on analysing and trying to understand the effect of the socio-cultural context on vernacular architecture and trying to reach some rules or understandings of how it works in order to reach a modern environmental dwelling that is suitable to this concept. The research method goes through analysing study cases from the traditional architecture models and the Nablus city is selected as a case study. This analytical and qualitative method can lead to deep understanding for how to benefit from vernacular architecture in Palestine in finding the future environmental residential construction. One of the main findings of this research is to set general and special rules for building sustainable buildings in Palestine from the socio-cultural point view, in order to be a reference for designers, stakeholders, ministry of planning, and municipalities.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Tese de Doutoramento em Tecnologias e Sistemas de Informação

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Tese de Doutoramento em Engenharia Biomédica.

Relevância:

10.00% 10.00%

Publicador:

Resumo:

Doctoral Thesis in Information Systems and Technologies Area of Information Systems and Technology