A Cancer Recognition Method Based on DNA Microarray

The accurate cancer classification is of great importance in clinical treatment. Recently, the DNA microarray technology provides a promising approach to the diagnosis and prognosis of cancer types. However, it has no perfect method for the multiclass classification problem. The difficulty lies in the fact that the data are of high dimensionality with small sample size. This paper proposed an automatic classification method of multiclass cancers based on Biomimetic pattern recognition (BPR). To the public GCM data set, the average correct classification rate reaches 80% under the condition that the correct rejection rate is 81%.

地球化学新方法在隐状矿床找矿预测中的应用研究

With the progress of prospecting, the need for the discovery of blind ore deposits become more and more urgent. To study and find out the method and technology for the discovery of blind and buried ores is now a priority task. New geochemical methods are key technology to discover blind ores. Information of mobile components related to blind ores were extracted using this new methods. These methods were tested and applied based on element' s mobile components migrating and enriched in geophysical-geochemical process. Several kinds of partial extraction techniques have tested based on element' s occurrence in hypergenic zone. Middle-large scale geochemical methods for exploration in forest and swamp have been tested. A serious of methods were tested and applied effetely about evaluation of regional geochemical anomaly, 1:25000 bedrock or soil geochemical methods sampling based on the net in dendritic water system instead of the normal net. 1. Element related with ores can be mobiled to migrate upwards and be absorpted by surface soil. These abnomal components can be concentrated by natural or artificial methods. These trace metalic ions partially exist in dissovlvable ion forms of active state, and partially have been absorbed by Fe-Mn oxide, soil and organic matter in the soil so that a series of reaction such as complex reaction have take place. Employing various partial extraction techniques, metallic ions related with the phase of the blind ores can be extracted, such as the technique of organic complex extraction, Fe-Mn oxide extraction and the extraction technique of metallic ions of various absorption phases. 2.1:200000 regional geochemical evaluation anomaly methods: Advantageous ore-forming areas were selected firstly. Center, concentration, morphological feature, belt of anomaly were choosed then. Geological and geochemical anomalies were combined. And geological and geochemical background information were restrained. Xilekuduke area in Fuyun sheet , Zhaheba area in Qiakuerte sheet, the west-north part in Ertai sheet and Hongshanzui anomaly in Daqiao sheet were selected as target areas, in Alertai, in the north of Xinjiang. in Xilekuduke area, 1:25000 soil geochemical methods sampling based on the net in dendritic water system was carried out. Cu anomaly and copper mineralization were determined in the center area. Au , Cu anomalies and high polarization anomaly were determined in the south part. Prospecting by primary halo and organic complex extraction were used to prognosis blind ore in widely rang outcrop of bedrock. 1:25000 bedrock or soil geochemical methods sampling based on the net in dendritic water system were used in transported overburden outside of mining area. Shallow seismic method and primary halo found a new blind orebody in mining area. A mineralization site was fou and outside of Puziwan gold mine, in the north of Shanxi province. Developing middle-large scale geochemical exploration method is a key technique based 1:200000 regional geochemical exploration. Some conditions were tested as Sampling density , distribution sites of sample, grain size of sample and occurrence of element for exploration. 1:50000 exploration method was advanced to sample clast sediment supplement clast sediment in valley. 1:25000 bedrock or soil geochemical methods sampling based on the net in dendritic water system was applied to sample residual material in A or C horizon. 1:2000 primary or soil halo methods used to check anomalies and determine mineralization. Daliang gold mineralization in the northern Moerdaoga was found appling these methods. Thermomagnetic method was tested in miniqi copper-polymetallic ore. Process methods such as grain size of sample, heated temperature, magnetic separating technique were tested. A suite of Thermomagnetic geochemical method was formed. This method was applied in Xiangshan Cu~Ni deposit which is cover by clast or Gobi in the eastern Xinjiang. Element's content and contrast of anomaly with Thermomagnetic geochemical method were higher than soil anomaly. Susceptibility after samples were heated could be as a assessment conference for anomaly. In some sectors thermo-magnetic Cu, Ni, Ti anomalious were found outside deposits area. There were strong anomal ies response up ore tested by several kind of partial extraction methods include Thermomagnetic, enzyme leach and other partial extractions in Kalatongke Cu-Ni deposit in hungriness area in the northern of Xinjiang. Element's anomalies of meobile were mainly in Fe-Mn oxide and salt. A Copper mineralization site in Xilekuduke anomaly area had been determined. A blind ore was foung by shallow seismic and geochemical method and a mineralization site was found outside this mining area in Puziwan gold deposit in shanxi province. A Gold mineralization site was found by 1:50000 geochemical exploration in Daliang, Inner Mongolia.

A型、D型人格影响冠心病预后的心理生理机制

Coronary heart disease （CHD）is a common cardiovascular disease in the elderly, is also a typical psychosomatic disease. Personality factors are very important in many psychological factors impacting on the prognosis of patients with CHD. The most influential personality factors to CHD are Type A and Type D personality. The previous research has shown that although Type A personality increased the prevalence of CHD, it cannot predict the development and prognosis after diagnosis. In contradict, Type D personality can predict prognosis. There is still no clinic-based or theory-based answer to the question: Why Type A personality cannot predict the outcome while Type D personality could predict the prognosis independently. The current research conducted a systematic investigation to the above question, which included one comparison study between CHD patients and control group, and four studies on reaction experiment and answered the question: why Type A personality cannot predict whereas Type D personality could effectively predict prognosis of CHD. The findings of the current research were: Type A and Type D personality influence CHD prognosis through different psychological mechanisms: both dimensions of Type D personality have direct influence on social support, whereas neither dimensions of Type A personality related to social support, directly of indirectly. Negative affection component of Type D personality significantly related to anxiety and depression, Social repression significantly related to anxiety but not depression. Both dimensions of Type A personality significantly related to anxiety but not depression. Neither under rest or diaphragmatic breathing conditions, Type A personality had no significant influence on vestibular autonomic reaction among healthy young males. Neither Type A nor Type D personality had significant influence on vestibular autonomic reaction among old CHD patients under rest condition. Type D personality predicted lower sympathetic excitation under rest condition, and lower cardiac vagal tone under diaphragmatic breathing condition among healthy young males. When actively reacted to stimuli (math calculation) under rest condition, Type A personality increased sympathetic excitation among healthy young males. When actively reacted to stimuli (math calculation) under diaphragmatic breathing condition, Type A personality increased cardiac vagal tone among the same group of subjects. When actively reacted to stimuli under neither condition, Type D personality showed no significant influence on vestibular autonomic reaction among young males. When passively reacted to stimuli under neither condition, Type A personality showed no significant influence on vestibular autonomic reaction among young males. When passively stimulated followed rest, Type D personality increased sympathetic excitation and decreased cardiac vagal tone among young males. When passively stimulated followed diaphragmatic breathing, Typed showed no significant influence on vestibular autonomic reaction among young males. The above results indicated that Type A and Type D personalities had different psychological mechanisms to the outcome of CHD treatment: neither dimensions of Type A personality had direct or indirect effects on social support; both dimensions of Type D personality had direct and indirect effects on social support. Negative affection component of Type D personality significantly related to anxiety and depression, Social repression significantly related to anxiety but not depression. Both dimensions of Type A personality significantly related to anxiety but not depression. Social support positively related to the outcome after CHD treatment. The biological mechanisms of Type A and Type B personality to CHD prognosis differed in the following ways: Type A personality increased sympathetic excitation when actively stimulated, but had no influence when passively stimulated among young male subjects. When passively stimulated after rest, Type D personality predicted high sympathetic excitation and low cardiac vagal tone among young males, but not vestibular autonomic reaction among young males. Key words: Type A personality, Type D personality, Coronary Heart Disease (CHD), Prognosis, Psychobiological Mechanisms

5-9岁儿童对常见病病因及其致病不确定性的认知发展

Research on children's naive concepts has previously tended to focus on the domains of physics and psychology, but more recently attention has turned to conceptual development in biology as a core domain of knowledge. Because of its familiarity, illness has been a popular topic for researchers in this domain. However, they have only studied the children’s understanding of its causes. Other aspects of illness, such as treatment and prognosis, have received little attention. This research addresses the development of 5- to 9-year-old children’s understanding of the causes of illness and their probabilities via open-ended and forced choice interviews. The results of this research are: 1) Most of the 5- to 7-year-old children used behavioral causes to explain illness, and the 9-year-old children primarily used biological causes to interpret illness. With age, more and more children selected psychological causes to explain illness. 2) Pre-school children did not over-generalize contagions to non-contagious illnesses. They used behavioral and biological causes to explain contagious illnesses. For non-contagious illnesses, they chose only behavioral causes. 3) Most of the children used only one kind of cause to explain illness. 4) Some preschool-aged children viewed outcomes of familiar causes of illness as probabilistic. With age, more and more could make uncertain predictions of illness. 5) The children’s understanding of the causes’ probabilities appeared to be based on naïve biology. 5- to 9-year-old children often made probabilistic predictions by analyzing a single cause of illness. 6) Children coming from higher educational backgrounds outperformed their counterparts coming from lower educational backgrounds with respect to understanding illness. 7) Specific knowledge acquired could generally improved the preschoolers’ understanding of causes of illness and their probabilities.