Molecular modeling on some human interleukins sharing gamma c of interleukin-2 receptor, and structure-function relationships

Five models for human interleukin-7 (HIL-7), HIL-9, HIL-13, HIL-15 and HIL-17 have been generated by SYBYL software package. The primary models were optimized using molecular dynamics and molecular mechanics methods. The final models were optimized using a steepest descent algorithm and a subsequent conjugate gradient method. The complexes with these interleukins and the common gamma chain of interleukin-2 receptor (IL-2R) were constructed and subjected to energy minimization. We found residues, such as Gln127 and Tyr103, of the common gamma chain of IL-2R are very important. Other residues, e.g. Lys70, Asn128 and Glu162, are also significant. Four hydrophobic grooves and two hydrophilic sites converge at the active site triad of the gamma chain. The binding sites of these interleukins interaction with the common gamma chain exist in the first helical and/or the fourth helical domains. Therefore, we conclude that these interleukins binds to the common gamma chain of IL-2R by the first and the fourth helix domain. Especially at the binding sites of some residues (lysine, arginine, asparagine, glutamic acid and aspartic acid), with a discontinuous region of the common gamma chain of IL-2R, termed the interleukins binding sites (103-210). The study of these sites can be important for the development of new drugs. (C) 2000 Elsevier Science B.V. All rights reserved.

超图划分与SFC的比较研究和数值软件可视化界面

本文重点对超图划分和空间填充曲线两类算法进行比较研究。在大规模科学计算的中，并行计算效率提升的一个关键在于将数据进行剖分，分配到相应处理器中，以及对处理器中的数据进行动态调整，数据剖分和数据调整是实现处理器节点之间负载均衡的关键。针对数据剖分和数据调整问题，目前主要通过两类手段解决，分别称为拓扑手段和几何手段。而超图划分和空间填充曲线作为这两类手段的代表，在数据剖分和数据调整过程中得到了广泛的应用。 解决超图划分问题的经典算法中，应用最为广泛是启发式算法，如FM算法等。本文以FM算法为例，给出了较为详细的分析。随着问题规模的不断扩大，这些传统的算法消耗的时间急剧增加，研究者们因此又提出了对超图进行多级划分的算法框架。本文将对这一算法框架的各阶段细节进行分析。 空间填充曲线可以对离散的多维空间进行线性遍历，将多维的问题转化为一维的问题。利用这种特性，在数据剖分过程中可以将数据进行排序，根据这一顺序对数据进行剖分。本文对空间填充曲线的生成和应用，以及几类常用的空间填充曲线的顺序编码生成算法进行分析。 超图划分和空间填充曲线在数据剖分应用中各有优缺点。超图划分对节点间通信量等优化目标可以进行更为准确的计算，可以得到对更为有效的减少节点间通信量的数据剖分，但是超图划分这一过程本身所需要的时间较多；而空间填充曲线可以在很短的时间内对数据进行剖分，但是无法对优化目标进行准确计算。我们对两者在数据剖分中的应用，以及应用不同的划分模型对整体计算的影响进行了分析比较，并进行了实验对观点进行了验证。 在文章的最后，结合实际项目对数值软件可视化界面的设计进行了阐述。

建立在小型计算机上的GPSS-F/1000通用仿真软件包

本文阐述了在小型计算机上建立的 GPSS-F/1000通用仿真软件包。该软件包不仅具有原 GPSS-F仿真软件的全部功能,并且使公用数组、系统参数的适配全部活化,通过子程序的形式参量传送赋给,从而,仿真时不必修改子程序的源程序。此外,增加了统计参数估计子程序集和图形绘制子程序集。

绘图专用字符库的建立与使用

本文概述了用专门的造字符软件 SYGEN 交互式地建立“绘图专用字符库”(包括汉字)的方法。文中着重论述了如何对国外引进的软件 SYGEN,在建库的设计思想,提高字符的存取速度,减少内、外存空间的占有等方面进行的改造,从而,用此方法能够简单而快速地建立使用方便、易于更新的绘图专用字符库。

扩展CSS仿真程序及其应用

本文介绍了一个连续-离散复合仿真程序。该程序的连续部分基本取自美国的 CSS 程序。经作者扩充后成为复合仿真程序。扩充的模块包括采样系统仿真模块、两点边值问题求解以及参量最优化等。作者提出的单纯形搜索法改进策略可以显著加快参量最优化过程的收敛速度。

井间地震速度层析成像方法与软件系统

Crosshole Seismic tomography has been broadly studied and applied in the fields of resource exploration and engineering exploration because of its special observing manner and better resolution than normal seismic exploration. This thesis will state the theory and method of Crosshole Seismic tomography. Basing on the previous studies，the thesis studied the initial velocity model，ray-tracing method, and developed the three-dimension tomography software. All the cells that a ray passes through are of the same velocities if the paths from transmitters to receivers are straight. The cells that the each ray passes through are recorded, and rays that pass through each cell are calculated. The ray average velocity which passes through a cell is set as the cell velocity. Analogously we can make a initial node velocity model because the velocity sum is calculated on the all cells which own to a certain node, and the cell number is summed about each nodes，the ratio of the velocity sum to the all cells number is set as the node velocity. The inversion result from the initial node velocity model is better than that of the average velocity model. Ray-bending and Shortest Path for Rays (SPR) have shortcomings and limitations respectively. Using crooked rays obtained from SPR rather than straight lines as the starting point can not only avoid ray bending converging to the local minimum travel time path, but also settle the no smooth ray problem obtained by SPR. The hybrid method costs much computation time, which is roughly equal to the time that SPR expends. The Delphi development tool based on the Object Pascal language standard has an advantage of object-oriented. TDTOM (Three Dimensions Tomography) was developed by using Delphi from the DOS version. Improvement on the part of inversion was made, which bring faster convergence velocity. TDTOM can be used to do velocity tomography from the first arrival travel time of the seismic wave, and it has the good qualities of friendly user interface and convenient operation. TDTOM is used to reconstruct the velocity image for a set of crosshole data from Karamay Oil Field. The geological explanation is then given by comparing the inversion effects of different ray-tracing methods. High velocity zones mean the cover of oil reservoir, and low velocity zones correspond to the reservoir or the steam flooding layer.

泥岩裂缝储层地震识别的理论和方法

During the exploration of fractured reservoirs, worldwide difficult problems will be encountered: how to locate the fractured zones, how to quantitatively determine the azimuth, density, and distribution of the fractures, and how to compute the permeability and porosity of the fractures. In an endeavor to solve these problems, the fractured shale reservoir in SiKou area of ShengLi oil field was chosen as a study area. A study of seismic predictive theory and methods for solving problems encountered in fractured reservoir exploration are examined herein. Building on widely used current fractured reservoir exploration techniques, new seismic theories and methods focusing on wave propagation principles in anisotropic medium are proposed. Additionally, integrated new seismic data acquisition and processing methods are proposed. Based on research and application of RVA and WA methods from earlier research, a new method of acoustic impedance varying with azimuth (IPVA) creatively is put forth. Lastly combining drilling data, well log data, and geologic data, an integrated seismic predictive method for cracked reservoir bed was formed. A summary of the six parts of research work of this paper is outlined below. In part one, conventional geologic and geophysical prediction methods etc. for cracked reservoir exploration are examined, and the weaknesses of these approaches discussed. In part two, seismic wave propagation principles in cracked reservoirs are studied. The wave equation of seismic velocity and attenuation factor in three kinds of fracture mediums is induced, and the azimuth anisotropy of velocity and attenuation in fracture mediums is determined. In part three, building on the research and application of AVA and WA methods by a former researcher, a new method of acoustic impedance creatively varying with azimuth (IPVA) is introduced. A practical software package utilizing this technique is also introduced. In part four, Base on previously discussed theory, first a large full azimuth 3d seismic data (70km~2) was designed and acquired. Next, the volume was processed with conventional processing sequence. Then AVA, WA, and IPVA processing was applied, and finally the azimuth and density of the fractures were quantitatively determined by an integrated method. Predictions were supported by well data that indicate the approach is highly reliable. in part five, geological conditions contributing to cracked reservoir bed formation are analyzed in the LuoJia area resulting in the discovery that the main fractured zones are related to fault distribution in the basin, that also control the accumulation of the oil and gas, the generation mechanisms and types of fractured shale reservoirs are studied. Lastly, by using full 3D seismic attributes, azimuth and density of cracked reservoir zones are successfully quantitative predicted. Using an integrated approach that incorporates seismic, geologic and well log data, the best two fractured oil prospects in LouJia area are proposed. These results herein represent a break through in seismic technology, integrated seismic predictive theory, and production technology for fractured reservoirs. The approach fills a void that can be applied both inside China, and internationally. Importantly, this technique opens a new exploration play in the ShengLi oil field that while difficult has substantial potential. Properly applied, this approach could play an important role toward stabilizing the oil field' production. In addition, this technique could be extended fracture exploration in other oil fields producing substantial economic reward.

A spatial sampling optimization package using MSN theory

The density and distribution of spatial samples heavily affect the precision and reliability of estimated population attributes. An optimization method based on Mean of Surface with Nonhomogeneity (MSN) theory has been developed into a computer package with the purpose of improving accuracy in the global estimation of some spatial properties, given a spatial sample distributed over a heterogeneous surface; and in return, for a given variance of estimation, the program can export both the optimal number of sample units needed and their appropriate distribution within a specified research area. (C) 2010 Elsevier Ltd. All rights reserved.

Strength of Offshore Pipelines in Different Operation States and Analyzing Software

在近海管线的铺设、安装、使用过程中有多种作业状态：在位、悬跨、挖沟、提吊、铺管等。各种状态下管线的受力特点不同,加上管线结构、海况和海底土壤等因素又都很复杂,所以近海管线的强度分析难度大、内容多。分别采用解析方法、数值方法（有限元法、打靶法）和二者结合来解决理论上的（如几何非线性、动边界等）、实用性方面的难点。在理论分析的基础上,编制了符合产业部门工程师使用要求的近海管线强度分析软件。介绍了该软件进行力学分析时采用的理论以及软件界面。

Thermal Strain Analysis of a Flip-Chip Package by a Modified Hybrid Method

介绍一种可用于微电子封装局部应变场分析的实验/计算混合方法,该方法结合了有限元的整体/局部模型和实时的激光云纹干涉技术,利用激光云纹干涉技术所测得的应变场来校核有限元整体模型的计算结果,并用整体模型的结果作为局部模型的边界条件,对实验难以确定的封装结构局部位置的应力、应变场进行分析.用这种方法对可控坍塌倒装封装结构在热载荷作用下焊球内的应变场分布进行了分析,结果表明该方法能够提供封装结构内应力-应变场分布的准确和可靠的结果,为微电子封装的可靠性分析提供重要的依据. For the reliability analysis of electronic packages, strains in very localized areas, such as an interconnection or a corner, need to be determined. In this paper, a modified hybrid method of global/local modeling and real time moire interferometry is presented. In this method, a simplified, coarsely meshed global model is developed to get rough information about the deformation of the microelectronic package. In order to make sure the global model has been reasonably simplified and the material properties ...

A practical package technique for FBG-based temperature independent sensor

A practical package technique for temperature independent Fiber Bragg grating sensor is proposed. A uniform strength cantilever with two FBG attached on the upper and lower surfaces was utilized as the key element. By detecting two wavelengths differential output, the applied force can be obtained and temperature effects can be eliminated. Experiment results show the sensor has linear response and output signal uctuates less than 12pm as temperature changes from -10 degrees C to 50 degrees C. The maximum thermal error is less than 0.3% of the full measurement range.