Molecular evolution of microcephalin, a gene determining human brain size

Microcephalin gene is one of the major players in regulating human brain development. It was reported that truncated mutations in this gene can cause primary microcephaly in humans with a brain size comparable with that of early hominids. We studied the m

Calcium-permeable acid-sensing ion channel is a molecular target of the neurotoxic metal ion lead

Acid-sensing ion channels (ASICs) are emerging as fundamental players in the regulation of neural plasticity and in pathological conditions. Here we showed that lead (Pb2+), a well known neurotoxic metal ion, reversibly and concentration-dependently inhib

应用多质—多评价者程序对评定误差的分析

Two kinds of rating bias ——halo effect and ego-centric effect were analyzed in multitrait-multirater matrix by this research. To get the multitrait-multirater matrix, ten college students watched the video-tapes of football matches and rated the performance of the players on several traits. After the interviewing of 41 football fans, the performance traits of four different positions in a football team were obtained using critical incident technique. The results indicate: comparing the heterotrait-monorater triangless, some rater's rating showed halo effect obviously; comparing the monotrait-heterorater diagonals, ego-centric effect can be shown in some extent on different traits. There were less interrater reliability on the rating of some ambiguous traits. The conclusion can be used on rater training. We can give the raters feedback about their rating bias by analyzing the multitrait-multirater matrix. The results are also helpful for rater training.