Exposure of spermatozoa to duroquinone may impair reproduction of the common carp (Cyprinus carpio) through oxidative stress

Toxicity of many waterborne organic contaminants to aquatic organisms is mediated through oxidative damages resulting from the production of reactive oxygen species (ROS). Using duroquinone as a model ROS inducer, we carried out in vitro and in vivo experiments to test the hypothesis that reproduction in common carp (Cyprinus carpio) can be impaired through oxidative damage of their spermatozoa. In vitro exposure of fish spermatozoa to 0, 12.5, 25, 50, 100 and 200 mu M duroquinone for 2 h showed a significant increase in the level of ROS in a dose-dependant manner. Sperm motility was significantly reduced in all exposure groups, but lipid peroxidation (LPO) and DNA strand break (measured by comet assay) were only enhanced at 50 mu M and above. A significant decrease in subsequent hatching rate was recorded in all the exposure groups, despite fertilization rate was not affected. In the in vivo experiment, spermatozoa were collected 24 and 72 h after fish received intra-peritoneal injections of 1.0 and 10 mg kg(-1) body weight duroquinone. DNA damage was clearly evident in spermatozoa of all treatment groups after 72 h exposure, and ROS was significantly enhanced in the high concentration group. LPO however, remained unchanged in both treatment groups. The overall results of both our in vitro and in vivo experiments demonstrated that duroquinone can induce ROS production in spermatozoa, which may impair sperm quality and subsequently reproductive success through oxidative stress. (c) 2006 Elsevier B.V. All rights reserved.

关于大学的竞争力及办学特色问题的探讨

为确保教育科研和人才培养达到既定目标,大学需要优化组织体系,包括硬件设施、组织形态、以人为本、课程改革等方面。在大学的学科建设工作中,如果给予学科带头人足够的权限,将有利于组成有特色且有竞争力的教育科研队伍;而从法制法规的高度来稳定和规范高校教师的职业资格、主体地位、成果评价与工资收入,将对中国未来的社会经济发展产生积极的作用。

中国科学院力学研究所2005年科技工作回顾

2005年，力学所经历了几件大事：一是完成了中国科学院知识创新工程试点二期的总结和创新三期筹划，并顺利通过了现场评估，为进入2006年开始的创新三期奠定了坚实基础；二是成功举办丁“庆祝力学研究所建所50周年暨钱学森回国50周年大会”；二是在国家和（部门）重点实验室的评估中，我所非线性力学国家重点实验室和高温气体动力学重点实验室被评为数理科学“良好类”实验室．

重复结构振动控制的降维方法

提出了对称结构、旋转周期结构和链式结构的振动控制的降维方法.以某种对称的方式设置广义坐标的凝聚、传感器、驱动器的位置以及输入与控制力的关系,即可使控制系统具有和结构同样的重复性.对凝聚了的广义坐标和系统输入采用适当的变换,即可通过执行一些子结构的控制问题实现整体系统的振动控制,从而使控制问题的维度显著降低.

Nonlinear Dynamic Response of Tension Leg Platform

Tension Leg Platform (TLP) is a typical compliant offshore structure for oil exploitation in deep water. Most of the existing mathematical models for analyzing the dynamic response of TLP are based on explicit or implicit assumptions that displacements (translations and rotations) are small magnitude. Herein a theoretical method for analyzing the nonlinear dynamic behavior of TLP with finite displacement is developed, in which multifold nonlinearities are taken into account, i.e. finite displacement, coupling of the six degrees of freedom, instantaneous position, instantaneous wet surface, free surface effects and viscous drag force. Using this theoretical model, we perform the numerical analysis of dynamic response of a representative TLP. The comparison between the degenerative linear solution of the proposed nonlinear model and the published one shows good agreements. Furthermore, numerical results are presented which illustrate that nonlinearities exert a distinct influence on the dynamic responses of the TLP.

Influence of Wind and Grain Size on Migration of Asymmetric Sand Waves

Large parts of shallow seas are covered by regular seabed patterns and sand wave is one kind of these patterns. The instability of the sedimentary structures may hazard pipelines and the foundations of offshore structures. In the last decade or so, it's a focus for engineers to investigate the movement mechanism of sand waves. Previous theoretical studies of the subject have developed a general model to predict the growth and migration of sand waves, which is based on the two-dimensional vertical shallow water equations and the bed-form deformation equations. Although the relation between wave-current flow and sand bed deformation has been established, the topographic influence has not been considered in the model. In this paper some special patterns, which are asymmetric and close to the reality, are represent as the perturbed seabed and the evolution of sand waves is calculated. The combination of a steady flow induced by wind and a sinusoidal tidal flow is considered as the basic flow. Finally the relations of some parameters (grain size, etc.) and sand waves' growth and migration are discussed, and the growth rate and migration speeds of asymmetric sand waves are carried out.

Physical Modeling of Current-Induced Seabed Scour around a Vibrating Submarine Pipeline

Most of the existing researches either focus on vortex-induced-vibrations (VIV) of a pipeline near a rigid boundary, or on seabed scour around a fixed pipeline. In the fields, pipeline vibration and seabed scour are actually always coupled. Based on the similarity analysis, a series of tests were conducted with a hydro-elastic facility to investigate the influence of pipe vibration on the local scour and the effects of scour process on the pipeline dynamic responses. Experimental results indicate that, there exist two phases in the process of sand scouring around the pipeline with small embedment, i.e. Phase I: scour beneath pipe without VIV, and Phase II: scour with VIV of pipe. It is also found that the gap-to-diameter ratio (e/D) has much effect upon the scour depth for the fixed pipes. For a given value of e/D, the vibrating pipes with close proximity to seabed may induce a deeper scour hole than the fixed ones. Within the examined gap-to-diameter ratio range (425 < e/D < 0.75), the influences of gap-to-diameter ratio on the maximum values of scour-depth for the case of vibrating pipes are not as much as those for the case of fixed pipes.

Study on the Performance of a Compact Compound Oil/Gas/Water Separator for Offshore Oil Industry

High-efficiency separation of the oil/gas/water mixtures is a significant issue in offshore oil industry. To reduce the total cost by means of reduction in weight and space compared with conventional separators, a novel compact compound oil/gas/water separator is developed. The research works on oil-gas-water separation by compound separating techniques is described in this paper. The innovative separator is a gravity settling tank with helical pipes within and T-shaped pipes outside. Both experiments and numerical simulations are presented to study the separating performance and efficiency of the helical pipes, which are the main part of the separator.

Deformation Twinning in Nanocrystalline NI

Deformation twinning is observed upon large plastic deformation in nanocrystalline (nc) Ni by transmission electron microscopy examinations. New and compelling evidence has been obtained for several twinning mechanisms that operate in nc grains, with the gain boundary emission of partial dislocations determined as the most proficient. Deformation twinning in nc Ni is discussed in comparison with molecular dynamics simulation results, based on generalized planar fault energy curves.

生物力学导论

在我国生物力学是门新兴学科，它既是医学和生物医学工程发展的需要，也是力学学科发展的必然生物力学以医学、生理学、生物学的学要为出发点和归宿，把力学的和生物学的方法有机地结合起来，去解决这些学科工程中所需解决的问题
本书详细介绍了这方面的有关知识和研究成果
附录与关键词: 生物力学 概论 生物力学