无指盘臭蛙免疫调节肽、其基因和变异体及其在制药中的应用

本发明涉及无指盘臭蛙免疫调节肽、基因和变异体及其在制药中的应用，属生物医学技术领域。无指盘臭蛙免疫调节肽是一种环状多肽，分子量1791.12道尔顿，等电点 9.84，无指盘臭蛙免疫调节肽的全序列为：Thr Ser Arg Cys Tyr Ile Gly Tyr Arg Arg Lys Val Val Cys Ser(TSRCYIGYRRKVVCS)，其第4位的半胱氨酸和第14位的半胱氨酸形成分子内二硫键。编码的基因由307个核苷酸组成，其中编码成熟部分的为第 141-186位核苷酸。无指盘臭蛙免疫调节肽原始序列中第4个氨基酸发生替代所产生的变异体，人工合成的无指盘臭蛙免疫调节肽及其变异体具有强烈的免疫调节活性和肿瘤抑制活性，作为制备免疫调节、肿瘤治疗和化疗药物的应用。本发明还具有序列简单、合成方便等优点。

Anti-HIV Actions of 7- and 10-Substituted Camptothecins (vol 15, pg 138, 2010)

The authors thank the anonymous reviewer for helpful comments on the early version of the manuscript. This work was financially supported by the earmarked fund for Modern Agro-industry Technology Research System, the Science Fund for Young Scholars in Sichuan Province (Grant No: ZQ 026-017), and the National 863 Project of China (No. 2008AA101001).

离子注入GaAs实现双包层掺镱光纤激光器被动调Q锁模

用离子注入的半绝缘GaAs晶片作为吸收体和输出镜,在双包层掺镱光纤激光器上实现了调Q锁模.离子注入的能量为400keV的As+离子,注入剂量为1016/cm2,然后在600℃下退火20min.当抽运功率为5W时,脉冲平均输出功率为200mW,调Q包络重复频率为50kHz,半高宽为4μs,锁模脉冲重复频率为15MHz。

Optimization of evanescent wave imaging for the visualization of protein adsorption layers

We have optimized the settings of evanescent wave imaging for the visualization of a protein adsorption layer. The enhancement of the evanescent wave at the interface brought by the incident angle, the polarized state of light beam as well as a gold layer is considered. In order to improve the image contrast of a protein monolayer in experiments, we have optimized three factors-the incident angle, the polarization of light beam, and the thickness of an introduced thin gold layer with a theoretical simulation.

2010年环境力学夏季讲习班简介

<正>2010年环境力学夏季讲习班于8月21日～25日在南京河海大学举办.本次讲习班由国家自然科学基金委员会数理科学部主办,河海大学承办,中国力学学会环境力学专业委员会、美国工程力学学会、江苏省力学学会、海岸灾害及防护教育

message from the workshop chairs the first international workshop on program debugging in china (iwpdc 2010)

National Laboratory for Parallel and Distributed Processing; The University of Hong Kong