Evolutionary history of the mtDNA 9-bp deletion in Chinese populations and its relevance to the peopling of east and southeast Asia

In total, 1218 Chinese from twelve ethnic groups and nine Han geographic groups were screened for the mtDNA 9-bp deletion motif. The frequency of the 9-bp deletion in all samples was 14.7% but ranged from 0% to 32% in the various ethnic groups. Three individuals had a triplication of the 9-bp segment. Phylogenetic and demographic analyses of the mtDNA hypervariable segment 1 (HVS1) sequences suggest that the 9-bp deletion occurred more than once in China. The majority of the Chinese deletion:haplotypes (about 90%) have a common origin as a mutational event following an initial expansion of modem humans in eastern Asia. Other deletion haplotypes and the three haplotypes with a 9-bp triplication may have arisen independently in the Chinese, presumably by replication error. HVS1 haplotype analysis suggests two possible migration routes of the 9-bp deletion in east and southeast Asia. Both migrations originated in China with one route leading to the Pacific Islands via Taiwan, the other to southeast Asia and possibly the Nicobar Islands. Along both routes of peopling, a decrease in HVS1 diversity of the mtDNA haplotypes is observed. The "Polynesian motif (16217T/C, 16247A/G, and 16261C/T)" and the 16140T/C, 16266C/A, or C/G polymorphisms appear specific to each migration route.

Length polymorphism of thymidylate synthase regulatory region in Chinese populations and evolution of the novel alleles

The tandemly repeated 28-bp sequence in the 5'-terminal regulatory, region of human thymidylate synthase (TSER), which has been reported to be polymorphic in different populations, was surveyed in 668 Chinese from 9 Han groups, 8 ethnic populations, and 3

Effects of human activities on migratory waterbirds at Lashihai Lake, China

Surveys on migratory waterbirds and their habitats at Lashihai Lake, China, were conducted from October 1999 to April 2000. Five fixed points, representing different degrees of habitat disturbance and quality, were selected around the lake. We used counts (n = 30) to compare diversity and abundance of waterbirds at each point and evaluate the effects of habitat disturbance. The distribution of waterbirds was affected by disturbance, with snore than one-third of the total species and nearly half of the total individuals occurring at the least disturbed point. Species richness was weakly and abundance was strongly correlated to habitat disturbance, but not to habitat quality. Habitat destruction and use of canoes were prominent at the lake. Naxi ethnic fishermen (n = 37) were interviewed. They caught 570 waterbirds between October 1999 and March 2000 in fishing nets. An estimation of the total number of waterbirds been trapped on the lake is 6164. Diving species were most susceptible. Conservation measures that should implement immediately include the cessation of habitat destruction, better plan for the development of tourism, a reduction in the number of canoes and zoning of the non-fishing area. (C) 2002 Elsevier Science Ltd. All rights reserved.

High prevalence of HIV-1 and hepatitis C virus coinfection among injection drug users in the southeastern region of Yunnan, China

The southeastern region of Yunnan province is a key site for drug trafficking and HIV-1 infection spread from the west of Yunnan and Laos to southeastern China. To investigate the prevalence of HIV-1 infection and hepatitis C virus (HCV) coinfection among injection drug users (IDUs) in southeastern Yunnan, three cohorts of 285 addicts, including 242 IDUs and 43 oral drug users, living in the cities of Gejiu and Kaiyuan and the county of Yanshan were studied. HIV-1 and HCV infections were detected by enzyme-linked immunosorbent assay and/or polymerase chain reaction. Data on the age, sex, risk behavior, drug use history, employment, ethnic background, and marriage status were obtained by interview. The overall prevalence of HIV-1 infection was 71.9%. The rate of HCV coinfection among 138 HIV-1-infected IDUs was 99.3%. Most HIV-infected IDUs were 20 to 35 years old (86.7%) and were ethnic Han (75.9%), suggesting that the epidemic in Yunnan is no longer confined to non-Han ethnic minorities, HIV prevalence in female IDUs (81.2%) was significantly higher than in male IDUs (68.2%) (p <.05). The prevalence of HIV infection reached 68.4% after 1 year of injection drug use. Needle/syringe sharing is the major high risk factor for the spread of HIV-1 and HCV infections. Large-scale educational campaigns are urgently needed to reduce the spread of HIV and HCV infection in these regions.

一类存在特权集的门限群签名方案

针对冯登国提出的“存在特权集的门限群签名”问题，旨在分析现有解决方案的安全缺陷并给出新的解决方案．首先基于有限域理论分析指出石怡等人给出的一种实现方案存在不足和安全隐患．然后推广了利用单签名构造群签名的思想，提出了具有4个变形的一类EIGamal类型门限群签名方案，从而解决了以上问题．这类方案还具有消息恢复、签名长度短等许多良好性质．最后，基于单签名的安全性假设，证明以上方案是安全的。

基于规则推导的特权隐式授权分析

介绍了一种研究系统特权安全问题的方法．由于其特有的迁移系统安全状态的能力，使得分析及保护系统特权都很困难，因此，传统访问控制研究中所采用的技术无法复制到该领域．在访问控制空间理论下，检查了系统特权的来源问题及其特点，从而将系统规则划分为约束规则与执行规则两类，分别描述授权的限制与效果．进一步对规则逻辑形式进行推导，发现特权操作间的特殊授权关系以及相关属性，并设计了一种快速构造授权推导图的算法．在此基础上，分析隐式授权安全问题可能存在的滥用特权威胁．最后对POSIX(portable operating system interface)标准的权能机制进行形式化描述，计算并构造其授权推导图．对标准设计中存在的滥用威胁提供了对策，有效地实现了与最小特权原则的一致性．

一种支持动态调节的最小特权安全策略架构

最小特权机制可为安全操作系统提供恰当的安全保证级.本文描述了一种支持动态调节的最小特权安全策略架构,它结合角色的职责隔离和域的功能隔离特性,通过一种基于进程上下文一角色、执行域和运行映像的权能控制机制,将每个进程始终约束在这些上下文允许的最小特权范围内.本文实例分析了该架构在安胜OS v4.0,一种自主开发的、符合GB17859-1999第四级--结构化保护级的安全操作系统中的实现.结果表明,它可支持安全操作系统实施动态调节的最小特权控制,并提供灵活有效的系统.

多策略适应的一种POSIX权能遗传算法

多数支持POSIX权能机制的安全操作系统提出了各自的权能遗传算法，但这些算法都只适用于特定的最小特权控制策略，并且存在语义冲突、安全目标不明确等问题，不能有效支持多种安全需求不同的特权策略。通过对一些现有算法的深入分析，提出了一种新的权能遗传算法，该算法引入策略关联的权能控制变量以及可信应用属性。实例分析表明本算法具有策略适应性和可用性，形式化分析和验证表明它可使系统满足特权策略的基本安全定理。

一个支持可信主体特权最小化的多级安全模型

对已有多级安全模型的可信主体支持进行回顾和分析,提出了DLS(离散标记序列)多级安全模型.该模型将可信主体的生命周期分解为一系列非可信状态,对每一个状态赋予一个敏感标记.可信主体的当前敏感标记等于当前非可信状态的敏感标记,非可信状态的切换由预定义的可信请求事件触发.从而可信主体的当前敏感标记可以根据其应用逻辑而动态调整.同时给出了模型保持系统安全性的安全状态和规则.与Bell模型等可信主体敏感标记范围模型相比,该模型在多级安全的策略范围内实现了可信主体的特权最小化.

X Window核心系统的民文支持

Linux系统对少数民族文字的支持需要建立在国际化机制基础上,本文在总结现有Linux国际化框架层次结构基础上,分析了X核心系统国际化的一些关键问题,并以增加藏文支持的实践为例,系统说明了增加民族文字支持所需对X核心系统进行的改动,对在相关项目中的实施情况和效果进行了评估,最后结合其他民族文字系统的研究,对这些工作的局限性进行了深入分析,并提出了今后的工作方向.

A型行为核心特征与血管紧张素转换酶基因型相关性研究

In order to study the role of inherited factors and Type A Behavior Pattern (TABP) in the development of CHD, the present study chose the angiotensin I-converting enzyme (ACE) gene as the target gene, and investigated the associations of TABP, the polymorphism of ACE gene with susceptibility to development of CHD in the healthy population and CHD patients from Northern China. 1. Correlation Analysis Between TABP and serum level of ACE in Chinese healthy individuals TABP and serum of ACE were determined in 137 Chinese healthy individuals. The results showed that there was a significant correlation between the scores of CH in TABP invertory and the serum level of ACE. 2 The distribution charicteristics of ACE gene polymorphism frequencies and association with serum level of ACE in Chinese healthy individuals population The polymorphism of ACE gene and serum of ACE were determined in 137 Chinese healthy individuals. The results showed that: the ethnic differences in I/D polymorphism of ACE gene are obvious; deletion polymorphism of the ACE gene is associated with serum ACE level. 3. The relationship between insertion/deletion polymorphism of ACE gene and CHD in a Chinese population I/D polymorphism in intron 16 of the ACE gene was determined by polymerase chain reaction(PCR) in a study of 109 patients with CHD. The results showed: The frequencies of DD genotype(0.39) and D allele(0.63) were higher among the CHD group than among the control subjects(0.12 and 0.42 respectively, P < 0.01). Furthermore, MI and multivessel disease was more strongly associated with (P < 0.01). It is indicated that D allele and DD gentype of ACE might be an important risk factor for CHD, especially for MI or multivessel disease in Chinese population. 4. Correlation Analysis Between Type A Behavior Pattern and the Polymorphism of ACE Gene The polymorphism of ACE gene and type A behavior pattern (TABP) survey were determined in 291 Chinese healthy individuals. The result showed that the higher frequency of rare D allele of an insertion/deletion (I/D) polymorphism of the angiotensin I-converting enzyme (ACE) gene was found in type A behavior individuals compared with type B behavior individuals in 291 healthy individuals; there was a significant correlation between the scores of CH in TABP invertory and DD genotype of the ACE gene. It is suggested that the behavioral attributes of competitiveness, achievement striving, hostility, being irritated easily and impatience may be associated with heredity. 5. Correlation Analysis Between Angiotensin I-Converting Enzyme Gene Polymorphism, Type A Behavior Pattern and Coronary Heart Disease in Chinese The polymorphism of ACE gene and type A behavior pattern (TABP) survey were determined in 109 patients with CHD. The results showed the development of coronary heart disease(CHD) is influenced mainly by the behavioral attributes of competitiveness, achievement striving, hostility, being irritated easily and impatience; the deletion polymorphism of ACE gene may be play a important role in the process of it. 6. Correlation Analysis Between Type A Behavior Pattern Core Components and the Polymorphism of ACE Gene The polymorphism of ACE gene and type A behavior pattern (TABP) survey were determined in1306 Chinese healthy individuals. The results showed that there was a significant correlation between the scores of CH in TABP invertory and DD genotype of the ACE gene. Furthermore, the behavioral attributes of hostility, being irritated easily and impatience may be associated with heredity. At the end of this research, in terms of theory, the research approaches of TABP and the factors influenced the relationship between TABP and CHD were explored and discussed. Furthermore, several new opinions were put forward.