Solid-state optical parallel morphological processor

Based on birefringence, a building-block stacking technique is suggested in this paper. A solid-state optical morphological processor module is thus developed, which is an integration of a beam array generator submodule, an optical connector submodule, and a Pockels readout optical modulator. It is shown that the technique is compact in construction, simple for fabrication, and insensitive to the environment.

Code conversion from signed-digit to complement representation based on look-ahead optical logic operations

We present, for the first time to our knowledge, a generalized lookahead logic algorithm for number conversion from signed-digit to complement representation. By properly encoding the signed-digits, all the operations are performed by binary logic, and unified logical expressions can be obtained for conversion from modified-signed-digit (MSD) to 2's complement, trinary signed-digit (TSD) to 3's complement, and quarternary signed-digit (QSD) to 4's complement. For optical implementation, a parallel logical array module using an electron-trapping device is employed and experimental results are shown. This optical module is suitable for implementing complex logic functions in the form of the sum of the product. The algorithm and architecture are compatible with a general-purpose optoelectronic computing system. (C) 2001 Society of Photo-Optical Instrumentation Engineers.

Fetntosecond pulse shaping with space-to-time conversion based on planar optics

We propose a novel structure of planar optical configuration for implementation of the space-to-time conversion for femtosecond pulse shaping. The previous apparatuses of femtosecond pulse shaping are 4f Fourier-transforming type system that is usually large, expensive, difficult to align. The planar integration of free-space optical systems on solid substrates is an optical module with the attractive advantages of compact, reliable and robust. This apparatus is analyzed in details and the design of the particular lens for femtosecond pulse shaping based on planar optics is presented. (c) 2006 Elsevier GmbH. All rights reserved.

一种检测光刻机激光干涉仪测量系统非正交性的新方法

提出一种精确检测光刻机激光干涉仪测量系统非正交性的新方法。将对准标记曝光到硅片表面并进行显影;利用光学对准系统测量曝光到硅片上的对准标记理论曝光位置与实际读取位置的偏差;由推导的位置偏差与非正交因子、坐标轴尺度比例、过程引入误差的线性模型,根据最小二乘原理计算出干涉仪测量系统的非正交性。实验结果表明,利用该方法使用同一硅片在不同旋转角下进行测量,干涉仪测量系统非正交因子的测量重复精度优于0.01 μrad,坐标轴尺度比例的测量重复精度优于0.7×10-6。使用不同的硅片进行测量,非正交因子的测量再现性优于

ICF靶场中光束口径与列阵间隔的研究

从靶场反射镜架模块的机械结构设计布局所需几何空间的角度出发，根据大口径、列阵器件的特殊要求，给出符合“神光Ⅲ”装置总体技术要求的ICF靶场光束口径与列阵间隔之间的关系，得出靶场△纵、△横应满足的公式．

用于机载激光测深系统的时间间隔测量模块

机载海洋激光测深系统不仅要求精确测量激光从海表的入射点到海底目标点之间的距离，还要精确测定飞机到海表入射，点之间的距离，为水深数据的海浪校正而确定平均海平面以及波高。为此设计和研制了一高精度时间间隔测量器，该单元基于专用时间数字转换芯片开发，采用延迟线插入法技术，双通道工作，具有高时间分辨率(最高可达250ps)和高测量重复率的特性。给出硬件和软件设计方法以及单元的测试结果。

20-W average power, high repetition rate, nanosecond pulse with diffraction limit from an all-fiber MOPA system

In this article, we report an all-fiber master oscillator power amplifier (MOPA) system, which can provide high repetition rate and nanosecond pulse with diffraction-limit. The system was constructed using a (2 + 1) X 1 multimode combiner. The Q-Switched, LD pumped Nd:YVO4 solid-state laser wets used (is master oscillator. The 976-nm fiber-coupled module is used as pump source. A 10-m long China-made Yb3+-doped D-shape double-clad large-mode-area fiber was used as amplifier fiber. The MOPA produced as much as 20-W average power with nanosecond pulse and near diffraction limited. The pulse duration is maintained at about 15 its during 50-175 kHz. The system employs a simple and compact architecture and is therefore suitable for the use in practical applications such as scientific and military airborne LIDAR and imaging. Based oil this system. the amplification performances of. the all fiber amplifier is investigated. (C) 2008 Wiley Periodicals, Inc.

激光尘埃粒子计数器微型光学传感器的研究

研制成功便携式激光尘埃粒子计数器的核心部件——微型光学传感器。该传感器采用直角散射光收集形式。以高功率半导体激光器作为光源，同时采用高性能的PIN型光电二极管作为光电探测器。散射光收集系统为单一大数值孔径的球面反射镜，其对粒子散射光的收集角范围从20°到160°。粒子散射光信号是脉冲信号，其频谱成份主要在高频段，所以在PIN型光电二极管后用一个带通式前置放大器来消除外界的低频噪声．根据米氏散射理论计算了该光学传感器的光散射响应特性，并用聚苯乙烯标准粒子实测了该光学传感器的性能。结果表明，该系统具有高的信噪

判别分析系统应运于生物标本鉴定的初步研究

计算机技术和数学方法、手段应用于生物标本鉴定的研究工作在国外开展已有多年，但在国内却并没有许多人涉猎，也没有受到足够的重视。 鉴于这一领域的重要性及其实际意义，本文综合、扩充、改进了多元统计判别分析和模糊模式识别中的多种定量化判别方法，初步在计算机上实现了一个可用于生物标本鉴定或其它与判别、识别有关方面的系统，并将其用于桔梗科沙参属三个种：泡沙参、多歧沙参和裂叶沙参及菖蒲科中两个种的标本鉴定上面，获得了比较满意的判别效果。同时，为了弥补数量化标本鉴定的不足，本文作者还设计开发了一个描述性的基于检索表的人机交互式的标本鉴定模块。另外，本系统还包括模糊系统聚类和典型相关分析等模块，可供生物分类及其它定量分析运算时选用。 对于以上各种判别、识别方法的差异及优劣，文中根据实例做出了综合分析和比较，并认为在所有方法当中，逐步判别法和模糊协方差识别法最适宜于生物标本鉴定之用。最后，作者展望了未来计算机用于生物标本鉴定的前景。

新疆阜康地区森林资源与环境的空间分析

研究了新疆阜康地区森林植被资源与环境的特征和其30年来的变化，利用Arcinfo强大的空间分析功能，对资源、DEM模型、景观指数、环境价值和新疆降水量的地统计学规律进行较全面的分析。本文分为五个部分： 1、新疆阜康地区森林资源与环境空间数据库的建立森林资源与环境空间数据库的建立是它们空问分析的基础。利用多期的遥感图象和该区的地形图，建立森林分类图形和属性库（包括森林和环境自变量集）一体化的GIS空间数据库。为了提高TM遥感图象的分类精度，利用ERDAS图象处理软件，对它进行包括主成分、降噪、去条带和自然色彩变换等增强处理，采用监督分类和人工判读相结合的方法进行分类，采用R2V、ERDAS、Arcview、Arcinfo等软件的集成，使得小班面层与某些线层的无缝联接。成功地形成一套适于西部GIS的森林资源与环境空间数据库的技术路径。此外，对新疆阜康北部地区森林资源动态进行初步分析。 2、新疆阜康地区数字高程模型(DEM)及其粗差检测分析为了提高生态建模的精度，模拟和提取该区的地面特征至关重要。在已建立的森林资源与环境空间数据库的支持下，利用Arcinfo和ERDAS，建立了新疆阜康地区的1：5万数字高程模型(DEM)。通过提取地形的海拔、坡度、坡向特征因子，分析森林植被的垂直分布。通过对DEM的粗差检测分析，分析阜康地区的数字高程模型精度。 3、新疆阜康地区景观格局变化分析在1977年、1987年、1999年森林资源与环境空间数据库的支持下，利用景观分析软件编制三个时段的新疆阜康地区植被景观类型图，并分析了近30年来新疆阜康地区景观动态与景观格局变化。结果表明：①在此期间整个研究区的斑块数减少，斑块平均面积扩大，景观中面积在不同景观要素类型之间的分配更加不均衡，景观面积向少数几种类型聚集。说明了在这期间阜康地区的景观类型有向单一化方向发展的趋势;②农耕地分布呈破碎化的趋势，斑块平均面积变小，斑块间离散程度也更高：这些变化说明人为的经济活动在阜康地区的加剧，③天然林面积减少较多，水域的面积却呈现上升的趋势，冰川及永久积雪的面积呈下降趋势， 4、新疆阜康地区森林生态效益的初步分析从广义森林生态效益定义出发，针对12种森林生态效益因变量不完全独立、且各自的自变量集不完全相同，引入具有多对多特征且整体上相容的似乎不相关广义线性模型。通过构造12种森林生态效益的“有效面积系数”和“市场逼近系数”，在森林资源与环境空间数据库的支持下，对新疆阜康地区两期的森林生态效益进行科学的计量。结果表明：新疆阜康地区的森林生态效益货币量1987年是90673.8万元，1999年是84134.4万元，总体上呈下降趋势。 5、利用新疆气象站资料研究年降雨量的空间分布规律利用ArcGIS地统计学模块，在2000年新疆气候信息空间数据库和新疆DEM模型的支持下，做出了新疆地区的年降水量空间分布图。根据新疆气候资料建立趋势而分析模型、模拟了新疆降水量空间分布的趋势值。采用3种算法（距离权重法、普通Kriging法、协同Kriging方法）计算并比较分析了研究区多年的平均降水量的时空变化。利用模拟产生的精度最优的栅格降水空间数据库，建立的多年平均降水资源信息系统，可快速计算研究区内任一地域单元中降水的总量及其空间变化，可以生成高精度的气候要素空间分布图。

Modular Organization in a Cell: Concepts and Applications

Network biology is conceptualized as an interdisciplinary field, lying at the intersection among graph theory, statistical mechanics and biology. Great efforts have been made to promote the concept of network biology and its various applications in life s

Characterization and Comparison of the Tissue-Related Modules in Human and Mouse

Background: Due to the advances of high throughput technology and data-collection approaches, we are now in an unprecedented position to understand the evolution of organisms. Great efforts have characterized many individual genes responsible for the interspecies divergence, yet little is known about the genome-wide divergence at a higher level. Modules, serving as the building blocks and operational units of biological systems, provide more information than individual genes. Hence, the comparative analysis between species at the module level would shed more light on the mechanisms underlying the evolution of organisms than the traditional comparative genomics approaches. Results: We systematically identified the tissue-related modules using the iterative signature algorithm (ISA), and we detected 52 and 65 modules in the human and mouse genomes, respectively. The gene expression patterns indicate that all of these predicted modules have a high possibility of serving as real biological modules. In addition, we defined a novel quantity, "total constraint intensity,'' a proxy of multiple constraints (of co-regulated genes and tissues where the co-regulation occurs) on the evolution of genes in module context. We demonstrate that the evolutionary rate of a gene is negatively correlated with its total constraint intensity. Furthermore, there are modules coding the same essential biological processes, while their gene contents have diverged extensively between human and mouse. Conclusions: Our results suggest that unlike the composition of module, which exhibits a great difference between human and mouse, the functional organization of the corresponding modules may evolve in a more conservative manner. Most importantly, our findings imply that similar biological processes can be carried out by different sets of genes from human and mouse, therefore, the functional data of individual genes from mouse may not apply to human in certain occasions.

Interaction between human interleukin-16 and CD4 receptor of HIV-1

AIM: To study the interaction between human interleukin-16 (IL-16) and the receptor CD4 (T-lymphocyte differentiation antigen) of human immunodeficiency virus type 1 (HIV-1). METHODS: Two structurally con served regions (SCRs) of human IL-16 were built by the SYBYL/Biopolymer module using the corresponding transmembrane (TM) domain of human interleukin-1 (HIL-4) and HIL-2 as the templates. The coordinates for amino-terminal residue sequence, carboxyl-terminal residue sequences, and cytoplasm loops were generated using Biopolymer's LOOP SEARCH algorithm. RESULTS: HIL-16 first formed a homodimer, then contacted with CD4 dimer further forming a dimeric complex. Subsequently, the dimeric complex constructed the tetrameric complex by two disulfide bridges between the cysteines of HIL-16 (Cys31-Cys31). CONCLUSION: The interaction model is useful to propose the action mechanism of HIL-16 and is beneficial for rational designing of novel anti-HIV drugs.

Molecular modeling on human CCR5 receptors and complex with CD4 antigens and HIV-1 envelope glycoprotein gp120

AIM: To investigate the interaction between human CCR5 receptors (CCR5) and HIV-1 envelope glycoprotein gp120 (HIV-1 gp120) and HIV-1 receptor CD4 antigens (CD4). METHODS: The structurally con served regions (SCR) of human CCR5 was built by the SYBYL/Biopolymer module using the corresponding transmembrane (TM) domain of bacteriorhodopsin (bR) as the template. The coordinates for amino-ter minal residue sequence, and carboxyl-terminal residue sequence, extracellular and cytoplasmic loops were generated using LOOP SEARCH algorithm. Subsequently the structural model was merged into the complex with HIV-1 gp120 and CD4. RESULTS: Human CCR5 interacted with both an HIV-1 gp120 and CD4. The N-terminal residues (especially Met1 and Gln4) of human CCR5, contacted with CD4 residues, mainly 7Nith one span (56 - 59) of CD4 in electrostatic interaction and hydrogen-bonds. The binding sites of human CCR5 were buried in a hydrophobic center surrounded by a highly basic periphery. On the other hand, direct interatomic contacts were made between ? CCR5 residues and 6 gp120 amino-acid residues, which included van der Waals contacts, hydrophobic interaction, and hydrogen bonds. CONCLUSION: The interaction model should be helpful for rational design of novel anti-HIV drugs.

High-frequency characterization of packaging network in to-can photodiode modules

A simple method for analyzing the effects of TO packaging network on the high-frequency response of photodiode modules is presented. This method is established based on the relations of the scattering parameters of the packaging network, photodiode chip, and module. It is shown that the results obtained by this method agree well with those obtained by the conventional comparison method. The proposed method is much more convenient since only the electrical domain measurements are required. (C) 2008 Wiley Periodicals, Inc.