Interaction between human interleukin-16 and CD4 receptor of HIV-1


Autoria(s): Yang, J; Liu, CQ
Data(s)

2000

Resumo

AIM: To study the interaction between human interleukin-16 (IL-16) and the receptor CD4 (T-lymphocyte differentiation antigen) of human immunodeficiency virus type 1 (HIV-1). METHODS: Two structurally con served regions (SCRs) of human IL-16 were built by the SYBYL/Biopolymer module using the corresponding transmembrane (TM) domain of human interleukin-1 (HIL-4) and HIL-2 as the templates. The coordinates for amino-terminal residue sequence, carboxyl-terminal residue sequences, and cytoplasm loops were generated using Biopolymer's LOOP SEARCH algorithm. RESULTS: HIL-16 first formed a homodimer, then contacted with CD4 dimer further forming a dimeric complex. Subsequently, the dimeric complex constructed the tetrameric complex by two disulfide bridges between the cysteines of HIL-16 (Cys31-Cys31). CONCLUSION: The interaction model is useful to propose the action mechanism of HIL-16 and is beneficial for rational designing of novel anti-HIV drugs.

Identificador

http://159.226.149.42/handle/152453/5167

http://www.irgrid.ac.cn/handle/1471x/50921

Direitos

Interaction between human interleukin-16 and CD4 receptor of HIV-1

Fonte

Yang, J; Liu, CQ.Interaction between human interleukin-16 and CD4 receptor of HIV-1,21,547-553,(SCI-E):

Palavras-Chave #Chemistry, Multidisciplinary; Pharmacology & Pharmacy
Tipo

期刊论文