The role of H-bonds on the structure and dynamics of very concentrated polymer solutions

153 p.

Copia de una carta remitida por la Secretaría de Estado del Vaticano al Vicario General de Barcelona, José María Torrent, en la que se informa al último de la actitud a seguir ante la propuesta del Ministro de Justicia de la República, Manuel de Irujo, de apertura de iglesias al culto.

Fecha: 29-12-1937 original (>1970 copia) / Unidad de instalación: Carpeta 48 - Expediente 8-9 / Nº de pág.: 3 (mecanografiadas)

Recopilación de artículos sobre la geografía vasca, y nota del "Diario de Navarra" sobre las investigaciones del profesor Angel Viñas sobre la Guerra Civil.

Fecha: 11-8-1972/9-5-1982 / Unidad de instalación: Carpeta 48 - Expediente 7-18 / Nº de pág.: 7 (mecanografiadas)

An empirical comparison of the performance of alternative option pricing models

Published as an article in: Investigaciones Economicas, 2005, vol. 29, issue 3, pages 483-523.

Copia de una carta remitida por Saturnino de Gantxegi en la que se solicita colaboración para ayudar a los vascos presos en el Puerto de Santa María.

Fecha: s.f. (>1970 copia) / Unidad de instalación: Carpeta 45 - Expediente 2-16 / Nº de pág.: 3 (mecanografiadas)

Evaluation of the conventional surveying equipment applied to deformation analysis of heritage buildings. A case study: the bell tower of Santa María la Blanca church in Agoncillo (La Rioja, Spain)

Contributed to: "Measuring the Changes": 13th FIG International Symposium on Deformation Measurements and Analysis; 4th IAG Symposium on Geodesy for Geotechnical and Structural Enginering (Lisbon, Portugal, May 12-15, 2008).

[A_Vitoria_SantaMaria] Documentación geométrica de las excavaciones de la Catedral de Santa María (Vitoria-Gasteiz). Mayo 2000-Junio 2003

[ES] Información sobre este proyecto ha servido de base a los siguientes artículos:

Las aportaciones del Condado de Treviño a las instituciones de Vitoria en la Edad Moderna: La Colegial de Santa María y el Hospital de Santiago

Ponencia presentada en I Congreso de Estudios Históricos del Condado de Treviño: 850 aniversario de la fundación de la Villa de Treviño, celebrado los días 1,2 y 3 de junio de 2011 en Treviño (Condado de Treviño)

El ultimatum de María Jesús

Duración (en horas): Más de 50 horas. Destinatario: Estudiante y Docente

A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12

Background: Colorectal cancer (CRC) is a disease of complex aetiology, with much of the expected inherited risk being due to several common low risk variants. Genome-Wide Association Studies (GWAS) have identified 20 CRC risk variants. Nevertheless, these have only been able to explain part of the missing heritability. Moreover, these signals have only been inspected in populations of Northern European origin. Results: Thus, we followed the same approach in a Spanish cohort of 881 cases and 667 controls. Sixty-four variants at 24 loci were found to be associated with CRC at p-values <10-5. We therefore evaluated the 24 loci in another Spanish replication cohort (1481 cases and 1850 controls). Two of these SNPs, rs12080929 at 1p33 (P-replication=0.042; P-pooled=5.523x10(-03); OR (CI95%)=0.866(0.782-0.959)) and rs11987193 at 8p12 (P-replication=0.039; P-pooled=6.985x10(-5); OR (CI95%)=0.786(0.705-0.878)) were replicated in the second Phase, although they did not reach genome-wide statistical significance. Conclusions: We have performed the first CRC GWAS in a Southern European population and by these means we were able to identify two new susceptibility variants at 1p33 and 8p12 loci. These two SNPs are located near the SLC5A9 and DUSP4 loci, respectively, which could be good functional candidates for the association signals. We therefore believe that these two markers constitute good candidates for CRC susceptibility loci and should be further evaluated in other larger datasets. Moreover, we highlight that were these two SNPs true susceptibility variants, they would constitute a decrease in the CRC missing heritability fraction.

Evidence for classification of c.1852_1853AA > GC in MLH1 as a neutral variant for Lynch syndrome

Background: Lynch syndrome (LS) is an autosomal dominant inherited cancer syndrome characterized by early onset cancers of the colorectum, endometrium and other tumours. A significant proportion of DNA variants in LS patients are unclassified. Reports on the pathogenicity of the c.1852_1853AA>GC (p.Lys618Ala) variant of the MLH1 gene are conflicting. In this study, we provide new evidence indicating that this variant has no significant implications for LS. Methods: The following approach was used to assess the clinical significance of the p.Lys618Ala variant: frequency in a control population, case-control comparison, co-occurrence of the p.Lys618Ala variant with a pathogenic mutation, co-segregation with the disease and microsatellite instability in tumours from carriers of the variant. We genotyped p.Lys618Ala in 1034 individuals (373 sporadic colorectal cancer [CRC] patients, 250 index subjects from families suspected of having LS [revised Bethesda guidelines] and 411 controls). Three well-characterized LS families that fulfilled the Amsterdam II Criteria and consisted of members with the p.Lys618Ala variant were included to assess co-occurrence and co-segregation. A subset of colorectal tumour DNA samples from 17 patients carrying the p.Lys618Ala variant was screened for microsatellite instability using five mononucleotide markers. Results: Twenty-seven individuals were heterozygous for the p.Lys618Ala variant; nine had sporadic CRC (2.41%), seven were suspected of having hereditary CRC (2.8%) and 11 were controls (2.68%). There were no significant associations in the case-control and case-case studies. The p.Lys618Ala variant was co-existent with pathogenic mutations in two unrelated LS families. In one family, the allele distribution of the pathogenic and unclassified variant was in trans, in the other family the pathogenic variant was detected in the MSH6 gene and only the deleterious variant co-segregated with the disease in both families. Only two positive cases of microsatellite instability (2/17, 11.8%) were detected in tumours from p.Lys618Ala carriers, indicating that this variant does not play a role in functional inactivation of MLH1 in CRC patients. Conclusions: The p.Lys618Ala variant should be considered a neutral variant for LS. These findings have implications for the clinical management of CRC probands and their relatives.

Cartas enviadas por Ramón María de Aldasoro a Justo Garate en 1940

8 cartas (mecanografiadas) ; 225x285 mmm. Ubicación: Caja 1 - Carpeta 20

Cartas enviadas por José Angel Ascunde a Justo Garate entre 1991 y 1994

9 cartas y 1 tarjeta de visita (mecanografiadas y manuscritas) ; 210x295mm. Ubicación: Caja 1 - Carpeta 70

Carta enviada por Angel Ayestarán a Justo Garate en 1982

1 carta (mecanografiada) ; 219x277mm. Ubicación: Caja 1 - Carpeta 78

Carta enviada por José María de Azcárraga a Justo Garate en 1964

1 carta (manuscrita) : 275x214mm. Ubicación: Caja 1 - Carpeta 81