In vitro activities of natural products against oral Candida isolates from denture wearers

Background: Candida-associated denture stomatitis is a frequent infectious disease. Treatment of this oral condition is difficult because failures and recurrences are common. The aim of this study was to test the in vitro antifungal activity of pure constituents of essentials oils. -- Methods: Eight terpenic derivatives (carvacrol, farnesol, geraniol, linalool, menthol, menthone, terpinen-4-ol, and aterpineol), a phenylpropanoid (eugenol), a phenethyl alcohol (tyrosol) and fluconazole were evaluated against 38 Candida isolated from denture-wearers and 10 collection Candida strains by the CLSI M27-A3 broth microdilution method. -- Results: Almost all the tested compounds showed antifungal activity with MIC ranges of 0.03-0.25% for eugenol and linalool, 0.03-0.12% for geraniol, 0.06-0.5% for menthol, a-terpineol and terpinen-4-ol, 0.03-0.5% for carvacrol, and 0.06-4% for menthone. These compounds, with the exception of farnesol, menthone and tyrosol, showed important in vitro activities against the fluconazole-resistant and susceptible-dose dependent Candida isolates. -- Conclusions: Carvacrol, eugenol, geraniol, linalool and terpinen-4-ol were very active in vitro against oral Candida isolates. Their fungistatic and fungicidal activities might convert them into promising alternatives for the topic treatment of oral candidiasis and denture stomatitis.

Long memory in return structures from developed markets

[En]The present study aimed at investigating the existence of long memory properties in ten developed stock markets across the globe. When return series exhibit long memory, the series realizations are not independent over time and past returns can help predict future returns, thus violating the market efficiency hypothesis. It poses a serious challenge to the supporters of random walk behavior of the stock returns indicating a potentially predictable component in the series dynamics. We computed Hurst-Mandelbrot’s Classical R/S statistic, Lo’s statistic and semi parametric GPH statistic using spectral regression. The findings suggest existence of long memory in volatility and random walk for logarithmic return series in general for all the selected stock market indices. Findings are in line with the stylized facts of financial time series.

Un proyecto de investigación para el desarrollo de la competencia comunicativa oral de los futuros docentes

El V Seminario de "El aula como ámbito de investigación sobre la enseñanza y aprendizaje de la lengua" se celebró en la Universidad del País Vasco (UPV/EHU), dando continuidad a los seminarios ya celebrados en la Universidad Autónoma de Barcelona, en la Universidad de Valencia, en la Universidad de Valladolid y en la Universidad de Braga (Portugal).

Análisis histológico e inmunohistoquímico de los subtipos de enfermedad liquenoide oral

176 p. : il.

Efectividad del método canguro en el tratamiento del dolor en neonatos prematuros y de bajo peso gestacional junto a sacarosa oral en la técnica punción del talón en la Unidad Neonatal.

Durante muchos años se consideró que los neonatos no experimentaban el dolor por su incapacidad para verbalizarlo. Así, concepciones erróneas hicieron que el dolor neonatal no fuese tratado. En la actualidad, existe evidencia científica que corrobora la capacidad para percibir el dolor, siendo necesario su tratamiento. Aun así, el miedo a los posibles efectos secundarios de los fármacos ha obstaculizado el estudio de nuevos fármacos para el tratamiento del dolor. Es por eso que las estrategias no farmacológicas han tomado gran relevancia en el tratamiento de procedimientos dolorosos menores, y como coadyuvantes de los fármacos en procedimientos de mayor intensidad. El método canguro que se define como un contacto piel a piel entre madre e hijo, surgió como una alternativa ante la escasez de incubadoras. Sin embargo, numerosas investigaciones han demostrado los grandes beneficios que aporta, considerándolo también como una medida no farmacológica eficaz en el alivio del dolor neonatal. El objetivo de este estudio es evaluar la efectividad del método canguro junto a la administración de sacarosa oral en la disminución del dolor, en comparación con el procedimiento estándar al realizar la prueba de talón. Para ello, se realizará un ensayo clínico aleatorizado dirigido a los neonatos prematuros y de bajo peso gestacional ingresados en la unidad de neonatal del Hospital universitario de Cruces. La variable principal a estudio es la valoración del dolor medido mediante la escala PIPP. Se compararán los datos recogidos en el grupo control e intervención y el análisis de datos se realizará usando el programa informático SPSS.

Birth Weight, Working Memory and Epigenetic Signatures in IGF2 and Related Genes: A MZ Twin Study

Neurodevelopmental disruptions caused by obstetric complications play a role in the etiology of several phenotypes associated with neuropsychiatric diseases and cognitive dysfunctions. Importantly, it has been noticed that epigenetic processes occurring early in life may mediate these associations. Here, DNA methylation signatures at IGF2 (insulin-like growth factor 2) and IGF2BP1-3 (IGF2-binding proteins 1-3) were examined in a sample consisting of 34 adult monozygotic (MZ) twins informative for obstetric complications and cognitive performance. Multivariate linear regression analysis of twin data was implemented to test for associations between methylation levels and both birth weight (BW) and adult working memory (WM) performance. Familial and unique environmental factors underlying these potential relationships were evaluated. A link was detected between DNA methylation levels of two CpG sites in the IGF2BP1 gene and both BW and adult WM performance. The BW-IGF2BP1 methylation association seemed due to non-shared environmental factors influencing BW, whereas the WM-IGF2BP1 methylation relationship seemed mediated by both genes and environment. Our data is in agreement with previous evidence indicating that DNA methylation status may be related to prenatal stress and later neurocognitive phenotypes. While former reports independently detected associations between DNA methylation and either BW or WM, current results suggest that these relationships are not confounded by each other.

Biodegradable thermoplastic elastomers: tuning viscoelastic properties and shape memory

286 p.

Efecto de la suplementación oral con monohidrato de creatina en la capacidad de sprint en jugadores de fútbol sala

Propósito: Esta investigación examina los efectos de la suplementación con creatina en los esfuerzos de alta intensidad no prolongados en el tiempo, más concretamente en la posible mejora de la capacidad de sprint en jugadores de fútbol sala. Método: el estudio está diseñado con formato doble ciego. Se ha realizado a 10 jugadores varones integrantes de un equipo de fútbol sala, unas mediciones antropométricas (masa total y estatura) y unas pruebas que miden su rendimiento, estrechamente relacionadas con la capacidad de “sprint” (Squat Jump, Counter Movement Jump y Sprint de 20 metros de distancia lanzado).Después de esta primera recogida de datos, los jugadores han sido incluidos en un grupo que ha sido suplementado con CREATINA, o en un grupo PLACEBO. Ambos grupos tomaron durante 6 días, 20 gramos de producto, y una vez finalizado este periodo, se repitieron de nuevo tanto las mediciones antropométricas, como las pruebas de rendimiento. Concluidas estas segundas mediciones, comenzaron a tomar únicamente 5 gramos diarios durante 28 días, y de nuevo, una vez acabado este periodo, se repitieron las pruebas y mediciones. Resultados: No ha habido diferencias significativas que muestren cambios del IMC en ninguno de los dos grupos. Si existen mejoras significativas en las pruebas de rendimiento de las segundas mediciones respecto a las primeras, pero no son achacables a la ingesta de monohidrato de creatina, ya que sujetos de ambos grupos han mejorado. Conclusión: la creatina no ha mejorado la capacidad de sprint de estos deportistas. IDIOMA: ESPAÑOL.

Incidental Memory of Younger and Older Adults for Objects Encountered in a Real World Context

Effects of context on the perception of, and incidental memory for, real-world objects have predominantly been investigated in younger individuals, under conditions involving a single static viewpoint. We examined the effects of prior object context and object familiarity on both older and younger adults' incidental memory for real objects encountered while they traversed a conference room. Recognition memory for context-typical and context-atypical objects was compared with a third group of unfamiliar objects that were not readily named and that had no strongly associated context. Both older and younger adults demonstrated a typicality effect, showing significantly lower 2-alternative-forced-choice recognition of context-typical than context-atypical objects; for these objects, the recognition of older adults either significantly exceeded, or numerically surpassed, that of younger adults. Testing-awareness elevated recognition but did not interact with age or with object type. Older adults showed significantly higher recognition for context-atypical objects than for unfamiliar objects that had no prior strongly associated context. The observation of a typicality effect in both age groups is consistent with preserved semantic schemata processing in aging. The incidental recognition advantage of older over younger adults for the context-typical and context-atypical objects may reflect aging-related differences in goal-related processing, with older adults under comparatively more novel circumstances being more likely to direct their attention to the external environment, or age-related differences in top-down effortful distraction regulation, with older individuals' attention more readily captured by salient objects in the environment. Older adults' reduced recognition of unfamiliar objects compared to context-atypical objects may reflect possible age differences in contextually driven expectancy violations. The latter finding underscores the theoretical and methodological value of including a third type of objects-that are comparatively neutral with respect to their contextual associations-to help differentiate between contextual integration effects (for schema-consistent objects) and expectancy violations (for schema-inconsistent objects).

El perfil criminológico en las fases de investigación y juicio oral. Un estudio de caso filicidio

Posibilidades de ayuda del perfil criminológico en el descubrimiento, identificación y captura del delincuente en el ámbito policial y forense judicial. Realización de un perfil criminológico acerca de un caso enjuiciado en la Audiencia Provincial de Gipuzkoa.

Aproximación al lenguaje femenino en la prensa escrita (revistas del corazón) y en el registro oral

Inmersión en el uso femenino del lenguaje a través del análisis de diversos artículos (bibliográficos, periodísticos), documentos y encuestas.

Scalable quantum memory in the ultrastrong coupling regime

Circuit quantum electrodynamics, consisting of superconducting artificial atoms coupled to on-chip resonators, represents a prime candidate to implement the scalable quantum computing architecture because of the presence of good tunability and controllability. Furthermore, recent advances have pushed the technology towards the ultrastrong coupling regime of light-matter interaction, where the qubit-resonator coupling strength reaches a considerable fraction of the resonator frequency. Here, we propose a qubit-resonator system operating in that regime, as a quantum memory device and study the storage and retrieval of quantum information in and from the Z(2) parity-protected quantum memory, within experimentally feasible schemes. We are also convinced that our proposal might pave a way to realize a scalable quantum random-access memory due to its fast storage and readout performances.