Astarloaren sintaxia eta hitz ordena naturala

[EN] This paper examines the syntactic ideas of Pablo Pedro Astarloa (1752-1806) as he explained in his Discursos filosóficos sobre la lengua primitiva (1805), and tries to put them in the context of the debate between rationalists and sensualists, who argued whether there is a «natural order» of words. Astarloa developed a system for accounting the word order in the primitive language of mankind (and hence in the Basque language) founded in three types of «nobleness», and in the principle that the noblest element precedes the less noble one. The first type (nobleza de origen) orders words according to their meaning. The second type (nobleza de ministerio) orders words according to the part of speech they belong to, or the semantic function they have. Finally, the third type (nobleza de mérito or de movilidad) considers the will for communication and, as a result, word order reflects the information structure. Moreover Astarloa ’s three types of nobleness are arranged in a hierarchy of superiority: movilidad > ministerio > origen. So Astarloa ’s syntax appears near to sensualists ’ conceptions on word order because it did not appeal for a fixed natural order of words; instead he proposed a variable word order based mainly on the communicative process.

Validity of Resting Energy Expenditure Predictive Equations before and after an Energy-Restricted Diet Intervention in Obese Women

11 p.

Regulación de la transcripción de los genes SND1 (Homo sapiens) y SNDp102 (Rattus norvegicus)

167 p. : il., graf.

La traducción de las lenguas de la publicidad

Eterio Pajares, Raquel Merino y José Miguel Santamaría (eds.)

Valor social y ética del deporte

Ponencia invitado en el congreso internacional XII congreso AEISAD."El Factor Humano: Cuando la diferencia la marcan las personas" 25/10/2012 San Sebastián - Coeditado por: Juan Aldaz Arregui, Alberto Dorado Suárez, Pedro Jesús Jiménez Martín, Anna Vilanova Soler

Mechanism of transport of saquinavir-loaded nanostructured lipid carriers across the intestinal barrier

[EN] The aims of this work were (i) to evaluate the potential of nanostructured lipid carriers (NLCs) as a tool to 24 enhance the oral bioavailability of poorly soluble compounds using saquinavir (SQV), a BCS class IV drug 25 and P-gp substrate as a model drug, and (ii) to study NLC transport mechanisms across the intestinal barrier. 26 Three different NLC formulations were evaluated. SQV transport across Caco-2 monolayers was enhanced up 27 to 3.5-fold by NLCs compared to SQV suspension. M cells did not enhance the transport of NLCs loaded with 28 SQV. The size and amount of surfactant in the NLCs influenced SQV's permeability, the transcytosis pathway 29 and the efflux of SQV by P-gp. An NLC of size 247 nm and 1.5% (w/v) surfactant content circumvented P-gp 30 efflux and used both caveolae- and clathrin-mediated transcytosis, in contrast to the other NLC formulations, 31 which used only caveolae-mediated transcytosis. By modifying critical physicochemical parameters of the 32 NLC formulation, we were thus able to overcome the P-gp drug efflux and alter the transcytosis mechanism 33 of the nanoparticles. These findings support the use of NLCs approaches for oral delivery of poorly 34 water-soluble P-gp substrates.

La alteridad en Europa hoy. Racismo e inmigración

Antonio Duplá Ansuategui, Piedad Frías Nogales e Iban Zaldúa (editores)

Fiabilidad de diferentes pruebas que se utilizan para evaluar el riesgo de lesión del miembro inferior en mujeres deportistas

233 p. : il. + anexo (247 p.)

Estudio sobre las relaciones entre la percepción de competencia, el estado de ánimo y la tolerancia al estrés en jóvenes deportistas en formación

247 p.

Transformaciones en el retablo mayor de San Miguel Arcángel de Lazkao (Gipuzkoa): del Barroco al Neoclasicismo

[ES] El retablo mayor de la localidad guipuzcoana de Lazkao fue realizado por Juan de Ursularre en 1683, siguiendo los parámetros de la retablística barroca. Queriendo engrandecer su aspecto, fue paulatinamente transformado durante el siglo XVIII. Por ello se concibió un nuevo cascarón con pinturas enviadas desde Madrid y más tarde se adecuó a los nuevos gustos neoclásicos mediante una radical reforma realizada en 1791 que consistió en eliminar todo atisbo de decoración barroca.

La leyenda de la violación de Lucrecia y la articulación del relato del reinado de Tarquinio el Soberbio en Tito Livio ("Ab Urbe Condita" 1.49-60)

[ES] El propósito de este trabajo es el de mostrar cómo Livio elabora el episodio de la violación de Lucrecia de tal manera que se conecta con los restantes episodios del reinado de Tarquinio el Soberbio, formando una unidad tan estrecha y bien dispuesta que éste se convierte en el punto culminante de un proceso que comienza con el inicio del reinado del último monarca romano. Livio no se limita a seleccionar y disponer en una simple secuencia temporal los hechos que la tradición atribuía al segundo Tarquinio, sino que los elabora y ordena con vistas a conseguir un relato efectivo desde la perspectiva literaria y narrativa y, como consecuencia de ello, convincente desde el punto de vista moral, una de sus principales preocupaciones.

A Reliable Method for Rhythm Analysis during Cardiopulmonary Resuscitation

nterruptions in cardiopulmonary resuscitation (CPR) compromise defibrillation success. However, CPR must be interrupted to analyze the rhythm because although current methods for rhythm analysis during CPR have high sensitivity for shockable rhythms, the specificity for nonshockable rhythms is still too low. This paper introduces a new approach to rhythm analysis during CPR that combines two strategies: a state-of-the-art CPR artifact suppression filter and a shock advice algorithm (SAA) designed to optimally classify the filtered signal. Emphasis is on designing an algorithm with high specificity. The SAA includes a detector for low electrical activity rhythms to increase the specificity, and a shock/no-shock decision algorithm based on a support vector machine classifier using slope and frequency features. For this study, 1185 shockable and 6482 nonshockable 9-s segments corrupted by CPR artifacts were obtained from 247 patients suffering out-of-hospital cardiac arrest. The segments were split into a training and a test set. For the test set, the sensitivity and specificity for rhythm analysis during CPR were 91.0% and 96.6%, respectively. This new approach shows an important increase in specificity without compromising the sensitivity when compared to previous studies.

LDLR and PCSK9 Are Associated with the Presence of Antiphospholipid Antibodies and the Development of Thrombosis in aPLA Carriers

Introduction The identification of the genetic risk factors that could discriminate non-thrombotic from thrombotic antiphospholipid antibodies (aPLA) carriers will improve prognosis of these patients. Several human studies have shown the presence of aPLAs associated with atherosclerotic plaque, which is a known risk factor for thrombosis. Hence, in order to determine the implication of atherosclerosis in the risk of developing thrombosis in aPLA positive patients, we performed a genetic association study with 3 candidate genes, APOH, LDLR and PCSK9. Material & Methods For genetic association study we analyzed 190 aPLA carriers -100 with non-thrombotic events and 90 with thrombotic events-and 557 healthy controls. Analyses were performed by chi(2) test and were corrected by false discovery rate. To evaluate the functional implication of the newly established susceptibility loci, we performed expression analyses in 86 aPLA carrier individuals (43 with thrombotic manifestations and 43 without it) and in 45 healthy controls. Results Our results revealed significant associations after correction in SNPs located in LDLR gene with aPLA carriers and thrombotic aPLA carriers, when compared with healthy controls. The most significant association in LDLR gene was found between SNP rs129083082 and aPLA carriers in recessive model (adjusted P-value = 2.55 x 10(-3); OR = 2.18; 95% CI = 1.49-3.21). Furthermore, our work detected significant allelic association after correction between thrombotic aPLA carriers and healthy controls in SNP rs562556 located in PCSK9 gene (adjusted P-value = 1.03 x 10(-2); OR = 1.60; 95% CI = 1.24-2.06). Expression level study showed significantly decreased expression level of LDLR gene in aPLA carriers (P-value < 0.0001; 95% CI 0.16-2.10; SE 0.38-1.27) in comparison to the control group. Discussion Our work has identified LDLR gene as a new susceptibility gene associated with the development of thrombosis in aPLA carriers, describing for the first time the deregulation of LDLR expression in individuals with aPLAs. Besides, thrombotic aPLA carriers also showed significant association with PCSK9 gene, a regulator of LDLR plasma levels. These results highlight the importance of atherosclerotic processes in the development of thrombosis in patients with aPLA.