Las sociedades cooperativas de vivienda. Especial referencia al País Vasco

[ES] Son muy diversos los sectores en los que ejercen su actividad las sociedades cooperativas. La sociedad cooperativa de viviendas es una clase específica de dentro de las de consumidores, regulada como una «clase» diferenciada en las leyes, que presenta particularidades que es preciso conocer. Constituyen entidades con un lugar propio dentro del sector inmobiliario con una nada despreciable contribución a la promoción de vivienda. En el País Vasco son en cuantía las más importantes después de las de trabajo asociado. La sociedad cooperativa de viviendas se caracteriza como empresa de participación dentro del sector inmobiliario, en la medida que son los propios usuarios de las viviendas los responsables de la toma de decisiones en la promoción inmobiliaria.

Mechanisms Responsible for the Trophic Effect of Beta-Adrenoceptors on the I-to Current Density in Type 1 Diabetic Rat Cardiomyocytes

Background/Aims: In diabetic ventricular myocytes, transient outward potassium current (I-to) amplitude is severely reduced because of the impaired catecholamine release that characterizes diabetic autonomic neuropathy. Sympathetic nervous system exhibits a trophic effect on I-to since incubation of myocytes with noradrenaline restores current amplitude via beta-adrenoceptor (beta AR) stimulation. Here, we investigate the intracellular signalling pathway though which incubation of diabetic cardiomyocytes with the beta AR agonist isoproterenol recovers I-to amplitude to normal values. Methods: Experiments were performed in ventricular myocytes isolated from streptozotocin-diabetic rats. I-to current was recorded by using the patch-clamp technique. Kv4 channel expression was determined by immunofluorescence. Protein-protein interaction was determined by coimmunoprecipitation. Results: Stimulation of beta AR activates first a G alpha s protein, adenylyl cyclase and Protein Kinase A. PKA-phosphorylated receptor then switches to the G alpha i protein. This leads to the activation of the beta AR-Kinase-1 and further receptor phosphorylation and arrestin dependent internalization. The internalized receptor-arrestin complex recruits and activates cSrc and the MAPK cascade, where Ras, c-Raf1 and finally ERK1/2 mediate the increase in Kv4.2 and Kv4.3 protein abundance in the plasma membrane. Conclusion: beta(2)AR stimulation activates a G alpha s and G alpha i protein dependent pathway where the ERK1/2 modulates the Ito current amplitude and the density of the Kv4.2 and Kv4.2 channels in the plasma membrane upon sympathetic stimulation in diabetic heart.

Análisis del tratamiento del medio físico en el planeamiento territorial de la Comunidad Autómoma del País Vasco (1940-2006).

851 p. : il.

Together we have it all ! Benefits of participation in collective emotional gatherings and communal coping

244 p.