Adenylate Cyclase Toxin Promotes Internalisation of Integrins and Raft Components and Decreases Macrophage Adhesion Capacity

10 p.

El análisis del entorno político y legal en el marco de la planificación estratégica en el sector turístico y hotelero

[ES] Las empresas turísticas se encuentran inmersas en un entorno cambiante, caracterizado por los avances tecnológicos, al aumento de la competencia global y a las consecuencias derivadas de la crisis económica mundial. Ante estas circunstancias, las empresas turísticas se ven obligadas a diseñar estrategias de marketing y llevar a cabo planes estratégicos. Pues bien, para entender el marketing y desarrollar estrategias eficaces, es fundamental entender el contexto en el que opera la empresa, puesto que en él se generan las oportunidades del mercado y se presentan las amenazas que van a condicionar su futuro. Entre las fuerzas que integran el entorno empresarial se encuentran la economía, la sociedad, la política o la demografía, entre otras.

La violencia legal del sistema penal medieval ejercida contra las mujeres

[ES]A lo largo de estas páginas se analiza la igualdad o desigualdad de las mujeres respecto a los varones ante el control formalizado de la justicia penal a la hora de condenarlas a penas tan rigurosas como los azotes, el destierro o la horca; y ante el control informal ejercido por la familia, reprimiendo los comportamientos considerados ilícitos al margen de los tribunalesde justicia públicos.

Influence of nutrient intake on antioxidant capacity, muscle damage and white blood cell count in female soccer players

11 p.

Are Bar Associations Anticompetitive? An Empirical Analysis of Recommended Prices for Legal Services in Spain

The European Commission Report on Competition in Professional Services found that recommended prices by professional bodies have a significant negative effect on competition since they may facilitate the coordination of prices between service providers and/or mislead consumers about reasonable price levels. Professional associations argue, first, that a fee schedule may help their members to properly calculate the cost of services avoiding excessive charges and reducing consumers’ searching costs and, second, that recommended prices are very useful for cost appraisal if a litigant is condemned to pay the legal expenses of the opposing party. Thus, recommended fee schedules could be justified to some extent if they represented the cost of providing the services. We test this hypothesis using cross‐section data on a subset of recommended prices by 52 Spanish bar associations and cost data on their territorial jurisdictions. Our empirical results indicate that prices recommended by bar associations are unrelated to the cost of legal services and therefore we conclude that recommended prices have merely an anticompetitive effect.

El bosque guipuzcoano en la Edad Moderna: aprovechamiento, ordenamiento legal y conflictividad

[ES]En este libro se analiza la evolución tanto del bosque guipuzcoano como del aprovechamiento, el ordenamiento legal y la conflictividad en torno al mismo, entre los siglos XV al XVIII.

Legal Cloudment LifeRay Edition

Este Proyecto Fin de Carrera (PFC) se enmarca en otro proyecto de mayor envergadura, cuyo objetivo final es estudiar la eficiencia en el desarrollo de soluciones informáticas para organizaciones fundamentadas en herramientas CMS Open Source(código libre) basadas en Java y PHP. El presente PFC se ha desarrollado en el área jurídica y se ha propuesto Liferay como CMS. A través del gestor se debía buscar la manera de compartir los documentos de tal manera que estuvieran alojados en un servidor donde cualquier usuario previamente registrado pudiera acceder a ellos desde un sitio remoto. Además debía tener una sección de calendario dónde crear eventos. Como gestor documental Liferay cumple con las expectativas, pudiendo satisfacer todas las funcionalidades necesarias del proyecto. El único inconveniente encontrado, ha sido el no poder desarrollar algunos detalles de algunos módulos para ceñirse exactamente a las necesidades deseadas. Idioma: Castellano.

La creación de spin-offs universitarias en la universidad española: marco legal

La creación, consolidación y proliferación de spin-offs universitarias requiere que se cumplan una serie de requisitos previos: inversión en I+D que contribuya a crear nuevas oportunidades tecnológicas; capital-riesgo para financiar las primeras etapas de desarrollo de una spin-off; una cultura favorable al emprendizaje en el entorno universitario; programas específicos de apoyo a la creación de spin-offs; un marco regulatorio-institucional que favorezca la I+D+i, la protección de la propiedad intelectual y la aproximación de los investigadores al mundo empresarial. En este artículo se analiza la reciente y previsible evolución del marco legal para la creación de spin-offs en la universidad española.

Plasma brain-derived neurotrophic factor levels, learning capacity and cognition in patients with first episode psychosis

Background: Cognitive impairments are seen in first psychotic episode (FEP) patients. The neurobiological underpinnings that might underlie these changes remain unknown. The aim of this study is to investigate whether Brain Derived Neurotrophic Factor (BDNF) levels are associated with cognitive impairment in FEP patients compared with healthy controls. Methods: 45 FEP patients and 45 healthy controls matched by age, gender and educational level were selected from the Basque Country area of Spain. Plasma BDNF levels were assessed in healthy controls and in patients. A battery of cognitive tests was applied to both groups, with the patients being assessed at 6 months after the acute episode and only in those with a clinical response to treatment. Results: Plasma BDNF levels were altered in patients compared with the control group. In FEP patients, we observed a positive association between BDNF levels at six months and five cognitive domains (learning ability,immediate and delayed memory, abstract thinking and processing speed) which persisted after controlling for medications prescribed, drug use, intelligence quotient (IQ) and negative symptoms. In the healthy control group, BDNF levels were not associated with cognitive test scores. Conclusion: Our results suggest that BDNF is associated with the cognitive impairment seen after a FEP. Further investigations of the role of this neurotrophin in the symptoms associated with psychosis onset are warranted.

Plastidic Phosphoglucose Isomerase Is an Important Determinant of Starch Accumulation in Mesophyll Cells, Growth, Photosynthetic Capacity, and Biosynthesis of Plastidic Cytokinins in Arabidopsis

Phosphoglucose isomerase (PGI) catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. It is involved in glycolysis and in the regeneration of glucose-6-P molecules in the oxidative pentose phosphate pathway (OPPP). In chloroplasts of illuminated mesophyll cells PGI also connects the Calvin-Benson cycle with the starch biosynthetic pathway. In this work we isolated pgi1-3, a mutant totally lacking pPGI activity as a consequence of aberrant intron splicing of the pPGI encoding gene, PGI1. Starch content in pgi1-3 source leaves was ca. 10-15% of that of wild type (WT) leaves, which was similar to that of leaves of pgi1-2, a T-DNA insertion pPGI null mutant. Starch deficiency of pgi1 leaves could be reverted by the introduction of a sex1 null mutation impeding beta-amylolytic starch breakdown. Although previous studies showed that starch granules of pgi1-2 leaves are restricted to both bundle sheath cells adjacent to the mesophyll and stomata guard cells, microscopy analyses carried out in this work revealed the presence of starch granules in the chloroplasts of pgi1-2 and pgi1-3 mesophyll cells. RT-PCR analyses showed high expression levels of plastidic and extra-plastidic beta-amylase encoding genes in pgi1 leaves, which was accompanied by increased beta-amylase activity. Both pgi1-2 and pgi1-3 mutants displayed slow growth and reduced photosynthetic capacity phenotypes even under continuous light conditions. Metabolic analyses revealed that the adenylate energy charge and the NAD(P) H/NAD(P) ratios in pgi1 leaves were lower than those of WT leaves. These analyses also revealed that the content of plastidic 2-C-methyl-D-erythritol 4-phosphate (MEP)-pathway derived cytokinins (CKs) in pgi1 leaves were exceedingly lower than in WT leaves. Noteworthy, exogenous application of CKs largely reverted the low starch content phenotype of pgi1 leaves. The overall data show that pPGI is an important determinant of photosynthesis, energy status, growth and starch accumulation in mesophyll cells likely as a consequence of its involvement in the production of OPPP/glycolysis intermediates necessary for the synthesis of plastidic MEP-pathway derived hormones such as CKs.