Perspectiva social de la infancia en algunas comunidades del País Vasco: Opiniones de las y los adolescentes de Santurtzi sobre sexismo

Resumen: El presente estudio ha intentado conocer la perspectiva que tienen las y los adolescentes de Santurtzi sobre el sexismo, eligiendo la adolescencia por su carácter fundamental en el desarrollo vital. Partimos de una investigación cualitativa llevada a cabo con 17 adolescentes a través de grupos de discusión sobre sexismo, patriarcado y alternativas de construcción personal, como son el movimiento feminista y el movimiento de nuevas masculinidades. Hemos podido corroborar el desconocimiento que todavía existe en materia de igualdad y la necesidad de intervenciones socioeducativas que de ello se desprenden, para así continuar con la lucha contra el patriarcado y contra la discriminación hacia la mujer, desde la perspectiva que nos aporta el sexismo ambivalente.

Life Expectancy, Human Capital, Social Security and Growth

Revised: 2006-11.-- Published as an article in: Journal of Public Economics 90(12), December, 2006, pp. 2323-2349.

The promoter of cell growth- and RNA protection-associated SND1 gene is activated by endoplasmic reticulum stress in human hepatoma cells

Background: Staphyloccocal nuclease domain-containing protein 1 (SND1) is involved in the regulation of gene expression and RNA protection. While numerous studies have established that SND1 protein expression is modulated by cellular stresses associated with tumor growth, hypoxia, inflammation, heat- shock and oxidative conditions, little is known about the factors responsible for SND1 expression. Here, we have approached this question by analyzing the transcriptional response of human SND1 gene to pharmacological endoplasmic reticulum (ER) stress in liver cancer cells. Results: We provide first evidence that SND1 promoter activity is increased in human liver cancer cells upon exposure to thapsigargin or tunicamycin or by ectopic expression of ATF6, a crucial transcription factor in the unfolded protein response triggered by ER stress. Deletion analysis of the 5'-flanking region of SND1 promoter identified maximal activation in fragment (-934, +221), which contains most of the predicted ER stress response elements in proximal promoter. Quantitative real- time PCR revealed a near 3 fold increase in SND1 mRNA expression by either of the stress- inducers; whereas SND1 protein was maximally upregulated (3.4-fold) in cells exposed to tunicamycin, a protein glycosylation inhibitor. Conclusion: Promoter activity of the cell growth- and RNA-protection associated SND1 gene is up-regulated by ER stress in human hepatoma cells.