25 años de cooperación al desarrollo en Euskadi : la política de las instituciones públicas y el sistema vasco de cooperación

El trabajo analiza las políticas de cooperación al desarrollo llevadas a cabo por las principales instituciones públicas del País Vasco durante los últimos 25 años. Para este propósito, el estudio se divide en dos grandes apartados. El primero se centra en el examen del diseño de dichas políticas, mientras que el segundo está orientado al análisis de la manera en que las mismas se han llevado a la práctica. Para ello, se han estudiado más de 300 documentos de siete administraciones de la CAPV y casi 7.000 intervenciones financiadas por ellas.

Garapenerako lankidetza Euskadin, 25 urte : erakunde publikoetako politika eta euskal lankidetza sistema

Lan honek, azken 25 urtetan zehar Euskal Herriko erakunde nagusienek aurrera eramandako Garapenerako Lankidetza politikak ditu aztergai. Helburu honekin, lana bi multzo nagusitan banatu da. Lehen analisia, aipaturiko politiken diseinuan oinarritzen da; eta bigarren analisiak aldiz, politika horiek aurrera eramandako modua du ikergai. Honetarako, Euskal Autonomia Erkidegoko zazpi erakunde nagusienetako 300 dokumentutik gora eta hauek finantzaturiko ia 7.000 jarduera aztertu dira.

La cooperación al desarrollo descentralizada : una propuesta metodológica para su análisis y evaluación

El texto que aquí se presenta es el resultado del trabajo llevado a cabo por el Grupo de Investigación sobre Análisis y Evaluación de Políticas de Cooperación al Desarrollo del Instituto Hegoa (UPV/EHU). El punto de partida del mismo es la preocupación por la todavía escasa fundamentación teórica de la cooperación descentralizada, pese a la importancia adquirida por la misma en algunos casos como el español. Desde esas premisas, se presenta un marco de referencia para el examen de dicha cooperación descentralizada, en base al cual se plantea asimismo un sistema de indicadores que pueda facilitar los procesos de análisis y evaluación de las políticas puestas en marcha en este ámbito.

Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus aureus

11 p.

La cocina del amor: alimentos afrodisiacos en la antigua Grecia

Presentado en el Simposio "La imagen del sexo en la antigüedad: ciclos de renovación de la vida", organizado por el Instituto de Historia del CSIC y celebrado en Barcelona del 21 al 23 de marzo de 2002.

Les jeunes face au marché du travail en France: entre difficultés d´insertion et stratégies de pénétration

En une génération, entre 1975 et 1995, le paysage du marché du travail auquel les jeunes font face a radicalement changé.

La cooperación al desarrollo de base local en Euskadi

El libro está editado en bilingüe castellano-euskera

Diderot como lugar de encuentro: estética, ética y retórica en El sobrino de Rameau

435 p.

Automatically exposing OpenLifeData via SADI semantic Web Services

Background: Two distinct trends are emerging with respect to how data is shared, collected, and analyzed within the bioinformatics community. First, Linked Data, exposed as SPARQL endpoints, promises to make data easier to collect and integrate by moving towards the harmonization of data syntax, descriptive vocabularies, and identifiers, as well as providing a standardized mechanism for data access. Second, Web Services, often linked together into workflows, normalize data access and create transparent, reproducible scientific methodologies that can, in principle, be re-used and customized to suit new scientific questions. Constructing queries that traverse semantically-rich Linked Data requires substantial expertise, yet traditional RESTful or SOAP Web Services cannot adequately describe the content of a SPARQL endpoint. We propose that content-driven Semantic Web Services can enable facile discovery of Linked Data, independent of their location. Results: We use a well-curated Linked Dataset - OpenLifeData - and utilize its descriptive metadata to automatically configure a series of more than 22,000 Semantic Web Services that expose all of its content via the SADI set of design principles. The OpenLifeData SADI services are discoverable via queries to the SHARE registry and easy to integrate into new or existing bioinformatics workflows and analytical pipelines. We demonstrate the utility of this system through comparison of Web Service-mediated data access with traditional SPARQL, and note that this approach not only simplifies data retrieval, but simultaneously provides protection against resource-intensive queries. Conclusions: We show, through a variety of different clients and examples of varying complexity, that data from the myriad OpenLifeData can be recovered without any need for prior-knowledge of the content or structure of the SPARQL endpoints. We also demonstrate that, via clients such as SHARE, the complexity of federated SPARQL queries is dramatically reduced.

Coherencia de Políticas para el Desarrollo en Euskadi: diagnóstico y propuestas

Resumen ejecutivo en euskera, inglés y español. Informe completo en español

Never-resting microglia: physiological roles in the healthy brain and pathological implications

Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveries have challenged the current view of microglia, showing their active and positive contribution to normal brain function. This Research Topic will review the novel physiological roles of microglia in the developing, mature and aging brain, under non-pathological conditions. In particular, this Research Topic will discuss the cellular and molecular mechanisms by which microglia contribute to the formation, pruning and plasticity of synapses; the maintenance of the blood brain barrier; the regulation of adult neurogenesis and hippocampal learning; and neuronal survival, among other important roles. Because these novel findings defy our understanding of microglial function in health as much as in disease, this Research Topic will also summarize the current view of microglial nomenclature, phenotypes, origin and differentiation, sex differences, and contribution to various brain pathologies. Additionally, novel imaging approaches and molecular tools to study microglia in their non-activated state will be discussed. In conclusion, this Research Topic seeks to emphasize how the current research in neuroscience is challenged by never-resting microglia.

La onomástica de las inscripciones romanas del País Vasco. Estructura del nombre personal y estatuto jurídico

Este trabajo se ha desarrollado a partir de la edición de las inscripciones romanas del País Vasco dentro del proyecto PETRAE Hispaniarum (Université Michel de Montaigne-Bordeaux III, Francia).

From the Cajal alumni Achucarro and Rio-Hortega to the rediscovery of never-resting microglia

Under the guidance of Ramon y Cajal, a plethora of students flourished and began to apply his silver impregnation methods to study brain cells other than neurons: the neuroglia. In the first decades of the twentieth century, Nicolas Achucarro was one of the first researchers to visualize the brain cells with phagocytic capacity that we know today as microglia. Later, his pupil Pio del Rio-Hortega developed modifications of Achucarro's methods and was able to specifically observe the fine morphological intricacies of microglia. These findings contradicted Cajal's own views on cells that he thought belonged to the same class as oligodendroglia (the so called "third element" of the nervous system), leading to a long-standing discussion. It was only in 1924 that Rio-Hortega's observations prevailed worldwide, thus recognizing microglia as a unique cell type. This late landing in the Neuroscience arena still has repercussions in the twenty first century, as microglia remain one of the least understood cell populations of the healthy brain. For decades, microglia in normal, physiological conditions in the adult brain were considered to be merely "resting," and their contribution as "activated" cells to the neuroinflammatory response in pathological conditions mostly detrimental. It was not until microglia were imaged in real time in the intact brain using two-photon in vivo imaging that the extreme motility of their fine processes was revealed. These findings led to a conceptual revolution in the field: "resting" microglia are constantly surveying the brain parenchyma in normal physiological conditions. Today, following Cajal's school of thought, structural and functional investigations of microglial morphology, dynamics, and relationships with neurons and other glial cells are experiencing a renaissance and we stand at the brink of discovering new roles for these unique immune cells in the healthy brain, an essential step to understand their causal relationship to diseases.