All the King's Men: del Pulitzer al Oscar

Eterio Pajares, Raquel Merino y José Miguel Santamaría (eds.)

Carta enviada por Oscar P. Aguilar a Justo Garate en 1955

1 carta (manuscrita) ; 225X140mm. Ubicación: Caja 1 - Carpeta 7

Determination of drugs used in combined cardiovascular therapy

Cardiovascular diseases are nowadays the first cause of mortality worldwide, causing around the 30% of global deaths each year. The risk of suffering from cardiovascular illnesses is strongly related to some factors such as hypertension, high cholesterol levels, diabetes, obesity The combination of these different risk factors is known as metabolic syndrome and it is considered a pandemic due to the high prevalence worldwide. The pathology of the disorders implies a combined cardiovascular therapy with drugs which have different targets and mechanisms of action, to regulate each factor separately. The simultaneous analysis of these drugs turns interesting but it is a complex task since the determination of multiple substances with different physicochemical properties and physiological behavior is always a challenge for the analytical chemist. The complexity of the biological matrices and the difference in the expected concentrations of some analytes require the development of extremely sensitive and selective determination methods. The aim of this work is to fill the gap existing in this field of the drug analysis, developing analytical methods capable of quantifying the different drugs prescribed in combined cardiovascular therapy simultaneously. Liquid chromatography andem mass spectrometry (LCMS/MS) has been the technique of choice throughout the main part of this work, due to the high sensitivity and selectivity requirements.

Constant mean curvature hypersurfaces with constant δ-invariant

We completely classify constant mean curvature hypersurfaces (CMC) with constant δ-invariant in the unit 4-sphere S4 and in the Euclidean 4-space E4.

Aproximación teórica de la lealtad de marca: enfoques y valoraciones

[ES] El concepto de lealtad no es nuevo en el mercadeo, por el contrario ha sido uno de los temas más investigados, sin embargo no se ha llegado a unificar criterios sobre su definición por ser un fenómeno complejo. Inicialmente, el estudio de la lealtad se abordó desde dos corrientes diferentes: como una actitud, donde se dan cabida sentimientos y afectos positivos a favor de una marca; como un comportamiento efectivo, materializado en compras repetidas de la misma marca. Luego, se consideró una corriente que plantea que la medición de la lealtad no concierne exclusivamente a la valoración del comportamiento de recompra o al compromiso, sino a ambos. El objetivo de este artículo es el describir los aspectos más relevantes del concepto de lealtad de marca, a partir de la revisión y análisis teórico, específicamente su definición, enfoques, métodos de medición y tipos, para presentar algunas consideraciones finales.

Regulación alfa1-adrenérgica de la corriente IKr cardiaca

149 p. : il., graf.

Model driven product line engineering : core asset and process implications

Reuse is at the heart of major improvements in productivity and quality in Software Engineering. Both Model Driven Engineering (MDE) and Software Product Line Engineering (SPLE) are software development paradigms that promote reuse. Specifically, they promote systematic reuse and a departure from craftsmanship towards an industrialization of the software development process. MDE and SPLE have established their benefits separately. Their combination, here called Model Driven Product Line Engineering (MDPLE), gathers together the advantages of both. Nevertheless, this blending requires MDE to be recasted in SPLE terms. This has implications on both the core assets and the software development process. The challenges are twofold: (i) models become central core assets from which products are obtained and (ii) the software development process needs to cater for the changes that SPLE and MDE introduce. This dissertation proposes a solution to the first challenge following a feature oriented approach, with an emphasis on reuse and early detection of inconsistencies. The second part is dedicated to assembly processes, a clear example of the complexity MDPLE introduces in software development processes. This work advocates for a new discipline inside the general software development process, i.e., the Assembly Plan Management, which raises the abstraction level and increases reuse in such processes. Different case studies illustrate the presented ideas.

Kv7 Channels Can Function without Constitutive Calmodulin Tethering

9 p.

Dealing with Energy-QoE Trade-Offs in Mobile Video

Scalable video coding allows an efficient provision of video services at different quality levels with different energy demands. According to the specific type of service and network scenario, end users and/or operators may decide to choose among different energy versus quality combinations. In order to deal with the resulting trade-off, in this paper we analyze the number of video layers that are worth to be received taking into account the energy constraints. A single-objective optimization is proposed based on dynamically selecting the number of layers, which is able to minimize the energy consumption with the constraint of a minimal quality threshold to be reached. However, this approach cannot reflect the fact that the same increment of energy consumption may result in different increments of visual quality. Thus, a multiobjective optimization is proposed and a utility function is defined in order to weight the energy consumption and the visual quality criteria. Finally, since the optimization solving mechanism is computationally expensive to be implemented in mobile devices, a heuristic algorithm is proposed. This way, significant energy consumption reduction will be achieved while keeping reasonable quality levels.

Wide Screening of Phage-Displayed Libraries Identifies Immune Targets in Planta

Microbe-Associated Molecular Patterns and virulence effectors are recognized by plants as a first step to mount a defence response against potential pathogens. This recognition involves a large family of extracellular membrane receptors and other immune proteins located in different sub-cellular compartments. We have used phage-display technology to express and select for Arabidopsis proteins able to bind bacterial pathogens. To rapidly identify microbe-bound phage, we developed a monitoring method based on microarrays. This combined strategy allowed for a genome-wide screening of plant proteins involved in pathogen perception. Two phage libraries for high-throughput selection were constructed from cDNA of plants infected with Pseudomonas aeruginosa PA14, or from combined samples of the virulent isolate DC3000 of Pseudomonas syringae pv. tomato and its avirulent variant avrRpt2. These three pathosystems represent different degrees in the specificity of plant-microbe interactions. Libraries cover up to 26107 different plant transcripts that can be displayed as functional proteins on the surface of T7 bacteriophage. A number of these were selected in a bio-panning assay for binding to Pseudomonas cells. Among the selected clones we isolated the ethylene response factor ATERF-1, which was able to bind the three bacterial strains in competition assays. ATERF-1 was rapidly exported from the nucleus upon infiltration of either alive or heat-killed Pseudomonas. Moreover, aterf-1 mutants exhibited enhanced susceptibility to infection. These findings suggest that ATERF-1 contains a microbe-recognition domain with a role in plant defence. To identify other putative pathogen-binding proteins on a genome-wide scale, the copy number of selected-vs.-total clones was compared by hybridizing phage cDNAs with Arabidopsis microarrays. Microarray analysis revealed a set of 472 candidates with significant fold change. Within this set defence-related genes, including well-known targets of bacterial effectors, are over-represented. Other genes non-previously related to defence can be associated through this study with general or strain-specific recognition of Pseudomonas.

Assisting blog publication: annotation, model transformation, and crossblogging techniques

Although blogs exist from the beginning of the Internet, their use has considerablybeen increased in the last decade. Nowadays, they are ready for being used bya broad range of people. From teenagers to multinationals, everyone can have aglobal communication space.Companies know blogs are a valuable publicity tool to share information withthe participants, and the importance of creating consumer communities aroundthem: participants come together to exchange ideas, review and recommend newproducts, and even support each other. Also, companies can use blogs for differentpurposes, such as a content management system to manage the content of websites,a bulletin board to support communication and document sharing in teams,an instrument in marketing to communicate with Internet users, or a KnowledgeManagement Tool. However, an increasing number of blog content do not findtheir source in the personal experiences of the writer. Thus, the information cancurrently be kept in the user¿s desktop documents, in the companies¿ catalogues,or in another blogs. Although the gap between blog and data source can be manuallytraversed in a manual coding, this is a cumbersome task that defeats the blog¿seasiness principle. Moreover, depending on the quantity of information and itscharacterisation (i.e., structured content, unstructured content, etc.), an automaticapproach can be more effective.Based on these observations, the aim of this dissertation is to assist blog publicationthrough annotation, model transformation and crossblogging techniques.These techniques have been implemented to give rise to Blogouse, Catablog, andBlogUnion. These tools strive to improve the publication process considering theaforementioned data sources.

Open Personalization: Involving Third Parties in Improving the User Experience of Websites

Traditional software development captures the user needs during the requirement analysis. The Web makes this endeavour even harder due to the difficulty to determine who these users are. In an attempt to tackle the heterogeneity of the user base, Web Personalization techniques are proposed to guide the users’ experience. In addition, Open Innovation allows organisations to look beyond their internal resources to develop new products or improve existing processes. This thesis sits in between by introducing Open Personalization as a means to incorporate actors other than webmasters in the personalization of web applications. The aim is to provide the technological basis that builds up a trusty environment for webmasters and companion actors to collaborate, i.e. "an architecture of participation". Such architecture very much depends on these actors’ profile. This work tackles three profiles (i.e. software partners, hobby programmers and end users), and proposes three "architectures of participation" tuned for each profile. Each architecture rests on different technologies: a .NET annotation library based on Inversion of Control for software partners, a Modding Interface in JavaScript for hobby programmers, and finally, a domain specific language for end-users. Proof-of-concept implementations are available for the three cases while a quantitative evaluation is conducted for the domain specific language.

Mikroblogintza tekniken erabilera programazioan sortzen diren zalantzak ebazteko

Gaur egun Twitter moduko mikroblogintza aplikazioak zalantzak argitzeko gero eta gehiago erabiltzen dira. Erabiltzaileak laguntza eskaera adierazi eta sare sozialaren bidez bere kontaktuei helarazi egiten zaie. Erabiltzaileak galdera eta erantzunen kudeaketa sare sozial nahaste baten barruan egin beharko du. Proiektuaren helburu nagusia mikroblogintza plataformetako kanala programazio lengoaien IDEen barruan bateratzea da, modu honetan laguntza eskatzeko prozesua IDEetan bertan kudeatzeko.

Effective and Robust Generalized Predictive Speed Control of Induction Motor

14 p.

Performance of an Ocean Energy Conversion System with DFIG Sensorless Control

The 2009/28/EC Directive requires Member States of the European Union to adopt a National Action Plan for Renewable Energy. In this context, the Basque Energy Board, EVE, is committed to research activities such as the Mutriku Oscillating Water Column plant, OWC. This is an experimental facility whose concept consists of a turbine located in a pneumatic energy collection chamber and a doubly fed induction generator that converts energy extracted by the turbine into a form that can be returned to the network. The turbo-generator control requires a precise knowledge of system parameters and of the rotor angular velocity in particular. Thus, to remove the rotor speed sensor implies a simplification of the hardware that is always convenient in rough working conditions. In this particular case, a Luenberger based observer is considered and the effectiveness of the proposed control is shown by numerical simulations. Comparing these results with those obtained using a traditional speed sensor, it is shown that the proposed solution provides better performance since it increases power extraction in the sense that it allows a more reliable and robust performance of the plant, which is even more relevant in a hostile environment as the ocean.